scholarly journals NS5-V372A and NS5-H386Y variations are responsible for differences in interferon α/β induction and co-contribute to the replication advantage of Japanese encephalitis virus genotype I over genotype III in ducklings

2020 ◽  
Vol 16 (9) ◽  
pp. e1008773
Author(s):  
Chenxi Li ◽  
Di Di ◽  
Hui Huang ◽  
Xin Wang ◽  
Qiqi Xia ◽  
...  
Keyword(s):  
Japanese Encephalitis Virus ◽  
Japanese Encephalitis ◽  
Encephalitis Virus ◽  
Interferon Α ◽  
Virus Genotype ◽  
Genotype I ◽  
Genotype Iii

scholarly journals Potential Role of Birds in Japanese Encephalitis Virus Zoonotic Transmission and Genotype Shift

Viruses ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 357
Author(s):  
Muddassar Hameed ◽  
Abdul Wahaab ◽  
Mohsin Nawaz ◽  
Sawar Khan ◽  
Jawad Nazir ◽  
...  
Keyword(s):  
Japanese Encephalitis Virus ◽  
Japanese Encephalitis ◽  
Encephalitis Virus ◽  
Zoonotic Transmission ◽  
In Vivo Studies ◽  
Genotype I ◽  
Genotype Iii

Japanese encephalitis (JE) is a vaccine-preventable disease caused by the Japanese encephalitis virus (JEV), which is primarily prevalent in Asia. JEV is a Flavivirus, classified into a single serotype with five genetically distinct genotypes (I, II, III, IV, and V). JEV genotype III (GIII) had been the most dominant strain and caused numerous outbreaks in the JEV endemic countries until 1990. However, recent data shows the emergence of JEV genotype I (GI) as a dominant genotype and it is gradually displacing GIII. The exact mechanism of this genotype displacement is still unclear. The virus can replicate in mosquito vectors and vertebrate hosts to maintain its zoonotic life cycle; pigs and aquatic wading birds act as an amplifying/reservoir hosts, and the humans and equines are dead-end hosts. The important role of pigs as an amplifying host for the JEV is well known. However, the influence of other domestic animals, especially birds, that live in high abundance and close proximity to the human is not well studied. Here, we strive to briefly highlight the role of birds in the JEV zoonotic transmission, discovery of birds as a natural reservoirs and amplifying host for JEV, species of birds susceptible to the JEV infection, and the proposed effect of JEV on the poultry industry in the future, a perspective that has been neglected for a long time. We also discuss the recent in vitro and in vivo studies that show that the newly emerged GI viruses replicated more efficiently in bird-derived cells and ducklings/chicks than GIII, and an important role of birds in the JEV genotype shift from GIII to GI.

scholarly journals The emerged genotype I of Japanese encephalitis virus shows an infectivity similar to genotype III in Culex pipiens mosquitoes from China

2019 ◽  
Vol 13 (9) ◽  
pp. e0007716 ◽  
Author(s):  
Muddassar Hameed ◽  
Ke Liu ◽  
Muhammad Naveed Anwar ◽  
Abdul Wahaab ◽  
Anum Safdar ◽  
...  
Keyword(s):  
Japanese Encephalitis Virus ◽  
Japanese Encephalitis ◽  
Culex Pipiens ◽  
Encephalitis Virus ◽  
Genotype I ◽  
Genotype Iii

scholarly journals Introduction of Japanese Encephalitis Virus Genotype I, India

2011 ◽  
Vol 17 (2) ◽  
pp. 319-321 ◽  
Author(s):  
Pradip V. Fulmali ◽  
Gajanan N. Sapkal ◽  
Sulabha Athawale ◽  
Milind M. Gore ◽  
Akhilesh C. Mishra ◽  
...  
Keyword(s):  
Japanese Encephalitis Virus ◽  
Japanese Encephalitis ◽  
Encephalitis Virus ◽  
Virus Genotype ◽  
Genotype I

scholarly journals Investigation of the genotype III to genotype I shift in Japanese encephalitis virus and the impact on human cases

2015 ◽  
Vol 30 (4) ◽  
pp. 277-289 ◽  
Author(s):  
Na Han ◽  
James Adams ◽  
Wei Fang ◽  
Si-Qing Liu ◽  
Simon Rayner
Keyword(s):  
Japanese Encephalitis Virus ◽  
Japanese Encephalitis ◽  
Encephalitis Virus ◽  
Genotype I ◽  
Genotype Iii ◽  
The Impact

scholarly journals Partial cross-protection between Japanese encephalitis virus genotype I and III in mice

2019 ◽  
Vol 13 (8) ◽  
pp. e0007601 ◽  
Author(s):  
Jianchao Wei ◽  
Xin Wang ◽  
Junjie Zhang ◽  
Shuang Guo ◽  
Linlin Pang ◽  
...  
Keyword(s):  
Japanese Encephalitis Virus ◽  
Japanese Encephalitis ◽  
Encephalitis Virus ◽  
Cross Protection ◽  
Virus Genotype ◽  
Genotype I
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