scholarly journals IL-23 supports host defense against systemic Candida albicans infection by ensuring myeloid cell survival

2019 ◽  
Vol 15 (12) ◽  
pp. e1008115 ◽  
Author(s):  
Selim Nur ◽  
Florian Sparber ◽  
Christina Lemberg ◽  
Eva Guiducci ◽  
Tiziano A. Schweizer ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Cell Survival ◽  
Host Defense ◽  
Myeloid Cell ◽  
Candida Albicans Infection

scholarly journals Drosophila melanogaster Thor and Response to Candida albicans Infection

2007 ◽  
Vol 6 (4) ◽  
pp. 658-663 ◽  
Author(s):  
A. Levitin ◽  
A. Marcil ◽  
G. Tettweiler ◽  
M. J. Laforest ◽  
U. Oberholzer ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Drosophila Melanogaster ◽  
Candida Albicans ◽  
Host Defense ◽  
Translational Control ◽  
Fungal Pathogen ◽  
Transcriptional Profiling ◽  
S2 Cells ◽  
Candida Albicans Infection ◽  
Opportunistic Fungal Pathogen

ABSTRACT We used Drosophila melanogaster macrophage-like Schneider 2 (S2) cells as a model to study cell-mediated innate immunity against infection by the opportunistic fungal pathogen Candida albicans. Transcriptional profiling of S2 cells coincubated with C. albicans cells revealed up-regulation of several genes. One of the most highly up-regulated genes during this interaction is the D. melanogaster translational regulator 4E-BP encoded by the Thor gene. Analysis of Drosophila 4E-BP null mutant survival upon infection with C. albicans showed that 4E-BP plays an important role in host defense, suggesting a role for translational control in the D. melanogaster response to C. albicans infection.

scholarly journals Role of Interleukin-18 in Host Defense against Disseminated Candida albicans Infection

2002 ◽  
Vol 70 (6) ◽  
pp. 3284-3286 ◽  
Author(s):  
Rogier J. L. Stuyt ◽  
Mihai G. Netea ◽  
Ineke Verschueren ◽  
Giamila Fantuzzi ◽  
Charles A. Dinarello ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Protective Effect ◽  
Host Defense ◽  
Gamma Interferon ◽  
Interleukin 18 ◽  
Ifn Γ ◽  
Candida Albicans Infection ◽  
Deficient Mice

ABSTRACT In mice injected intravenously with Candida albicans, administration of anti-interleukin-18 (IL-18) antibodies increased the yeast load in the kidneys. There was no effect on the organ load with Candida when gamma interferon (IFN-γ)-deficient mice were treated with anti-IL-18 antibodies, suggesting that the protective effect of IL-18 is mediated through endogenous IFN-γ.

scholarly journals CCR5-mediated Recruitment of NK Cells to the Kidney Is a Critical Step for Host Defense to Systemic Candida albicans Infection

2020 ◽  
Vol 20 (6) ◽  
Author(s):  
Nu Z. N. Nguyen ◽  
Vuvi G. Tran ◽  
Saerom Lee ◽  
Minji Kim ◽  
Sang W. Kang ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Nk Cells ◽  
Host Defense ◽  
Critical Step ◽  
Candida Albicans Infection

THE INFLUENCE OF WHOLE SONICATE BRUCELLA ABORTUS ANTIGEN ON THE CANDIDA ALBICANS INFECTION IN MICE

2009 ◽  
Vol 8 (1) ◽  
pp. 48-59
Author(s):  
A M.J ◽  
A S.S ◽  
A I.A ◽  
A Al-Oubaidy ◽  
A Alwan ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Brucella Abortus ◽  
Candida Albicans Infection

scholarly journals CD137 Signaling Is Critical in Fungal Clearance during Systemic Candida albicans Infection

2021 ◽  
Vol 7 (5) ◽  
pp. 382
Author(s):  
Vuvi G. Tran ◽  
Na N. Z. Nguyen ◽  
Byungsuk Kwon
Keyword(s):  
Candida Albicans ◽  
Defense Mechanisms ◽  
Tumor Necrosis ◽  
Fungal Infections ◽  
Fungal Growth ◽  
Wild Type ◽  
Agonistic Antibody ◽  
Innate Defense ◽  
Surface Receptor ◽  
Candida Albicans Infection

Invasive fungal infections by Candida albicans frequently cause mortality in immunocompromised patients. Neutrophils are particularly important for fungal clearance during systemic C. albican infection, yet little has been known regarding which surface receptor controls neutrophils’ antifungal activities. CD137, which is encoded by Tnfrsf9, belongs to the tumor necrosis receptor superfamily and has been shown to regulate neutrophils in Gram-positive bacterial infection. Here, we used genetic and immunological tools to probe the involvement of neutrophil CD137 signaling in innate defense mechanisms against systemic C. albicans infection. We first found that Tnfrsf9−/− mice were susceptible to C. albicans infection, whereas injection of anti-CD137 agonistic antibody protected the host from infection, suggesting that CD137 signaling is indispensable for innate immunity against C. albicans infection. Priming of isolated neutrophils with anti-CD137 antibody promoted their phagocytic and fungicidal activities through phospholipase C. In addition, injection of anti-CD137 antibody significantly augmented restriction of fungal growth in Tnfrsf9−/− mice that received wild-type (WT) neutrophils. In conclusion, our results demonstrate that CD137 signaling contributes to defense mechanisms against systemic C. albicans infection by promoting rapid fungal clearance.

Suppression of humoral response during the course of Candida albicans infection in mice

1984 ◽  
Vol 88 (1) ◽  
pp. 61-63 ◽  
Author(s):  
Juan Carlos Valdez ◽  
Oscar Enrique Meson ◽  
Graciela Aciar de Valdez ◽  
Angel Sirena
Keyword(s):  
Candida Albicans ◽  
Humoral Response ◽  
Candida Albicans Infection
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