scholarly journals Type I Interferon Induced Epigenetic Regulation of Macrophages Suppresses Innate and Adaptive Immunity in Acute Respiratory Viral Infection

2015 ◽  
Vol 11 (12) ◽  
pp. e1005338 ◽  
Author(s):  
Danielle N. Kroetz ◽  
Ronald M. Allen ◽  
Matthew A. Schaller ◽  
Cleyton Cavallaro ◽  
Toshihiro Ito ◽  
...  
Keyword(s):  
Viral Infection ◽  
Adaptive Immunity ◽  
Epigenetic Regulation ◽  
Type I Interferon ◽  
Type I ◽  
Respiratory Viral Infection ◽  
Innate And Adaptive Immunity ◽  
Acute Respiratory Viral Infection

scholarly journals Comparison of Type I Interferon Expression in Adult and Neonatal Mice during Respiratory Viral Infection

10.29007/ltkw ◽  
2019 ◽  
Author(s):  
Zifeng Liang
Keyword(s):  
Immune Response ◽  
Viral Infection ◽  
Mouse Models ◽  
Post Infection ◽  
Type I Interferon ◽  
Sendai Virus ◽  
Killer Cell ◽  
Type I ◽  
Respiratory Viral Infection ◽  
Neonatal Mice

The aim of this paper is to identify the difference of type I interferon expression in 2- day neonatal and six-to-eight-weeks adult mice infected by Sendai virus (SeV), a single- stranded RNA virus of the family Paramyxoviridae. Sendai virus mimics the influence of respiratory syncytial virus (RSV) on humans, but does not infect humans. Although RSV has a fatal impact on people across age groups, little is understood about this common virus and the disparity between neonatal and adult immune response to it. It has been suggested by past findings that Type I interferon mRNA is present in higher levels in adults than in neonates, however there is a greater amount of interferon proteins in neonates rather than adults. To test the hypothesis that neonates are more capable of interferon production and preventing the translation of viral protein, I observed mouse models of respiratory viral infection and determined the expression of IFN-α1, IFN-α2, IFN-α5, IFN-α6, IFN-α7, IFN-β in archived mouse lung tissue samples harvested on different days post-infection with quantitative real time PCR. Expression of Glyceraldehyde 3-phosphate dehydrogenase(GAPDH), a housekeeping gene expressed constitutively in all mouse models, was used as a positive control of the experiment. To determine the ideal concentration of primer used in qPCR, primer reconstitution, primer optimization, and gel electrophoresis were conducted in advance. In addition, technical replicates and biological replicates were used to reduce error and confirm results in qPCR. In accordance with previous discovery, I found an upward trend in adults’ interferon expression from post-infection day 1 to day 5, and levels off in day 7. In contrast, neonatal levels were much higher on day 1 and remained high over the course of infection. This explains how type I interferon expression is altered in neonates to help them clear the virus at the same efficiency as adults without causing inflammation. Future research on immune response differences in human infection should focus on the evaluation of interferon protein amounts, as well as the analysis of activation of molecules downstream of the type I interferon receptors, such as signal transducer and activator of transcription (STAT) protein family. It is also crucial to compare immune cells like macrophages and natural killer cell activity in adult and neonatal mice during viral infection.

scholarly journals CD40 Enhances Type I Interferon Responses Downstream of CD47 Blockade, Bridging Innate and Adaptive Immunity

2019 ◽  
Vol 8 (2) ◽  
pp. 230-245
Author(s):  
Suresh de Silva ◽  
George Fromm ◽  
Casey W. Shuptrine ◽  
Kellsey Johannes ◽  
Arpita Patel ◽  
...  
Keyword(s):  
Adaptive Immunity ◽  
Type I Interferon ◽  
Type I ◽  
Innate And Adaptive Immunity ◽  
Interferon Responses

Primary infection with simian immunodeficiency virus: plasmacytoid dendritic cell homing to lymph nodes, type I interferon, and immune suppression

Blood ◽  
2008 ◽  
Vol 112 (12) ◽  
pp. 4598-4608 ◽  
Author(s):  
Benoît Malleret ◽  
Benjamin Manéglier ◽  
Ingrid Karlsson ◽  
Pierre Lebon ◽  
Michelina Nascimbeni ◽  
...  
Keyword(s):  
T Cell ◽  
Lymph Nodes ◽  
Simian Immunodeficiency Virus ◽  
Adaptive Immunity ◽  
Immune Suppression ◽  
Primary Infection ◽  
Type I Interferon ◽  
Type I ◽  
Innate And Adaptive Immunity ◽  
Immunodeficiency Virus

AbstractPlasmacytoid dendritic cells (pDCs) are antigen-presenting cells that develop into type-I interferon (IFN-I)–producing cells in response to pathogens. Their role in human immunodeficiency virus (HIV) pathogenesis needs to be understood. We analyzed their dynamics in relation to innate and adaptive immunity very early during the acute phase of simian immunodeficiency virus (SIV) infection in 18 macaques. pDC counts decreased in blood and increased in peripheral lymph nodes, consistent with early recruitment in secondary lymphoid tissues. These changes correlated with the kinetic and intensity of viremia and were associated with a peak of plasma IFN-I. IFN-I and viremia were positively correlated with functional activity of the immune suppression associated enzyme indoleamine-2,3-dioxygenase (IDO) and FoxP3+CD8+ T cells, which both negatively correlated with SIV-specific T-cell proliferation and CD4+ T-cell activation. These data suggest that pDCs and IFN-I play a key role in shaping innate and adaptive immunity toward suppressive pathways during the acute phase of SIV/HIV primary infection.

scholarly journals The Efficacy of Radiotherapy Relies upon Induction of Type I Interferon–Dependent Innate and Adaptive Immunity

2011 ◽  
Vol 71 (7) ◽  
pp. 2488-2496 ◽  
Author(s):  
Byron C. Burnette ◽  
Hua Liang ◽  
Youjin Lee ◽  
Lukasz Chlewicki ◽  
Nikolai N. Khodarev ◽  
...  
Keyword(s):  
Adaptive Immunity ◽  
Type I Interferon ◽  
Type I ◽  
Innate And Adaptive Immunity

scholarly journals Contribution of STAT1 to innate and adaptive immunity during type I interferon-mediated lethal virus infection

2020 ◽  
Vol 16 (4) ◽  
pp. e1008525 ◽  
Author(s):  
So Ri Jung ◽  
Thomas M. Ashhurst ◽  
Phillip K. West ◽  
Barney Viengkhou ◽  
Nicholas J. C. King ◽  
...  
Keyword(s):  
Virus Infection ◽  
Adaptive Immunity ◽  
Type I Interferon ◽  
Type I ◽  
Innate And Adaptive Immunity

The Natural Alliance Between Type I Interferon and Dendritic Cells and Its Role in Linking Innate and Adaptive Immunity

2002 ◽  
Vol 22 (11) ◽  
pp. 1071-1080 ◽  
Author(s):  
Stefano M. Santini ◽  
Tiziana Di Pucchio ◽  
Caterina Lapenta ◽  
Stefania Parlato ◽  
Mariantonia Logozzi ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Adaptive Immunity ◽  
Type I Interferon ◽  
Type I ◽  
Innate And Adaptive Immunity
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