scholarly journals Neuronal Subtype and Satellite Cell Tropism Are Determinants of Varicella-Zoster Virus Virulence in Human Dorsal Root Ganglia Xenografts In Vivo

2015 ◽  
Vol 11 (6) ◽  
pp. e1004989 ◽  
Author(s):  
Leigh Zerboni ◽  
Ann Arvin
Keyword(s):  
Varicella Zoster Virus ◽  
Satellite Cell ◽  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
Cell Tropism ◽  
Varicella Zoster ◽  
Neuronal Subtype

An in vivo model of varicella-zoster virus latent infection of dorsal root ganglia

1990 ◽  
Vol 26 (1) ◽  
pp. 83-89 ◽  
Author(s):  
C. Sadzot-Delvaux ◽  
M. P. Merville-Louis ◽  
P. Delree ◽  
P. Marc ◽  
J. Piette ◽  
...  
Keyword(s):  
Varicella Zoster Virus ◽  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
Latent Infection ◽  
In Vivo Model ◽  
Varicella Zoster

scholarly journals Mechanisms of Varicella-Zoster Virus Neuropathogenesis in Human Dorsal Root Ganglia

2008 ◽  
Vol 82 (8) ◽  
pp. 3971-3983 ◽  
Author(s):  
Mike Reichelt ◽  
Leigh Zerboni ◽  
Ann M. Arvin
Keyword(s):  
Herpes Zoster ◽  
Varicella Zoster Virus ◽  
Satellite Cell ◽  
Satellite Cells ◽  
Dorsal Root ◽  
Severe Combined Immunodeficiency ◽  
Neuronal Cell ◽  
Cell Infection ◽  
Varicella Zoster

ABSTRACT Varicella-zoster virus (VZV) is a human alphaherpesvirus that infects sensory ganglia and reactivates from latency to cause herpes zoster. VZV replication was examined in human dorsal root ganglion (DRG) xenografts in mice with severe combined immunodeficiency using multiscale correlative immunofluorescence and electron microscopy. These experiments showed the presence of VZV genomic DNA, viral proteins, and virion production in both neurons and satellite cells within DRG. Furthermore, the multiscale analysis of VZV-host cell interactions revealed virus-induced cell-cell fusion and polykaryon formation between neurons and satellite cells during VZV replication in DRG in vivo. Satellite cell infection and polykaryon formation in neuron-satellite cell complexes provide mechanisms to amplify VZV entry into neuronal cell bodies, which is necessary for VZV transfer to skin in the affected dermatome during herpes zoster. These mechanisms of VZV neuropathogenesis help to account for the often severe neurologic consequences of herpes zoster.

scholarly journals Varicella-zoster virus infection of human dorsal root ganglia in vivo

2005 ◽  
Vol 102 (18) ◽  
pp. 6490-6495 ◽  
Author(s):  
L. Zerboni ◽  
C.-C. Ku ◽  
C. D. Jones ◽  
J. L. Zehnder ◽  
A. M. Arvin
Keyword(s):  
Virus Infection ◽  
Varicella Zoster Virus ◽  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
Varicella Zoster Virus Infection ◽  
Varicella Zoster

scholarly journals Upregulation of CXCL10 in Human Dorsal Root Ganglia during Experimental and Natural Varicella-Zoster Virus Infection

2010 ◽  
Vol 85 (1) ◽  
pp. 626-631 ◽  
Author(s):  
M. Steain ◽  
K. Gowrishankar ◽  
M. Rodriguez ◽  
B. Slobedman ◽  
A. Abendroth
Keyword(s):  
Virus Infection ◽  
Varicella Zoster Virus ◽  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
Varicella Zoster Virus Infection ◽  
Varicella Zoster

scholarly journals Evidence of Latent Varicella‐Zoster Virus in Rat Dorsal Root Ganglia

1998 ◽  
Vol 178 (s1) ◽  
pp. S48-S51 ◽  
Author(s):  
P. Annunziato ◽  
P. LaRussa ◽  
P. Lee ◽  
S. Steinberg ◽  
O. Lungu ◽  
...  
Keyword(s):  
Varicella Zoster Virus ◽  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
Varicella Zoster
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