scholarly journals The Elusive Role of the Prion Protein and the Mechanism of Toxicity in Prion Disease

2015 ◽  
Vol 11 (5) ◽  
pp. e1004745 ◽  
Author(s):  
Roberto Chiesa
Keyword(s):  
Prion Protein ◽  
Prion Disease ◽  
Mechanism Of Toxicity

Role of Prion Disease-Linked Mutations in the Intrinsically Disordered N-Terminal Domain of the Prion Protein

2013 ◽  
Vol 9 (11) ◽  
pp. 5158-5167 ◽  
Author(s):  
Xiaojing Cong ◽  
Nicola Casiraghi ◽  
Giulia Rossetti ◽  
Sandipan Mohanty ◽  
Gabriele Giachin ◽  
...  
Keyword(s):  
Prion Protein ◽  
Prion Disease ◽  
Intrinsically Disordered ◽  
Terminal Domain

scholarly journals Manganese Upregulates Cellular Prion Protein and Contributes to Altered Stabilization and Proteolysis: Relevance to Role of Metals in Pathogenesis of Prion Disease

2010 ◽  
Vol 115 (2) ◽  
pp. 535-546 ◽  
Author(s):  
Christopher J. Choi ◽  
Vellareddy Anantharam ◽  
Dustin P. Martin ◽  
Eric M. Nicholson ◽  
Jürgen A. Richt ◽  
...  
Keyword(s):  
Prion Protein ◽  
Prion Disease ◽  
Cellular Prion Protein

scholarly journals The First Report of the Prion Protein Gene (PRNP) Sequence in Pekin Ducks (Anas platyrhynchos domestica): The Potential Prion Disease Susceptibility in Ducks

Genes ◽  
2021 ◽  
Vol 12 (2) ◽  
pp. 193
Author(s):  
Min-Ju Jeong ◽  
Yong-Chan Kim ◽  
Byung-Hoon Jeong
Keyword(s):  
Prion Protein ◽  
Dna Sequence ◽  
Prion Disease ◽  
Protein Gene ◽  
Prnp Gene ◽  
Pekin Duck ◽  
Prion Protein Gene ◽  
First Report ◽  
Aggregation Propensity ◽  
Pekin Ducks

Pathogenic prion protein (PrPSc), converted from normal prion protein (PrPC), causes prion disease. Although prion disease has been reported in several mammalian species, chickens are known to show strong resistance to prion diseases. In addition to chickens, the domestic duck occupies a large proportion in the poultry industry and may be regarded as a potential resistant host against prion disease. However, the DNA sequence of the prion protein gene (PRNP) has not been reported in domestic ducks. Here, we performed amplicon sequencing targeting the duck PRNP gene with the genomic DNA of Pekin ducks. In addition, we aligned the PrP sequence of the Pekin duck with that of various species using ClustalW2 and carried out phylogenetic analysis using Molecular Evolutionary Genetics Analysis X (MEGA X). We also constructed the structural modeling of the tertiary and secondary structures in avian PrP using SWISS-MODEL. Last, we investigated the aggregation propensity on Pekin duck PrP using AMYCO. We first reported the DNA sequence of the PRNP gene in Pekin ducks and found that the PrP sequence of Pekin ducks is more similar to that of geese than to that of chickens and mallards (wild ducks). Interestingly, Pekin duck PrP showed a high proportion of β-sheets compared to that of chicken PrP, and a high aggregation propensity compared to that of avian PrPs. However, Pekin duck PrP with substitutions of chicken-specific amino acids showed reduced aggregation propensities. To the best of our knowledge, this is the first report on the genetic characteristics of the PRNP sequence in Pekin ducks.

Detection of cutaneous prion protein deposits could help diagnose GPI‐anchorless prion disease with neuropathy

2021 ◽  
Author(s):  
Hiroyuki Honda ◽  
Kosuke Matsuzono ◽  
Kota Satoh ◽  
Masayoshi Fujisawa ◽  
Satoshi O. Suzuki ◽  
...  
Keyword(s):  
Prion Protein ◽  
Prion Disease ◽  
Protein Deposits

scholarly journals Doxycycline control of prion protein transgene expression modulates prion disease in mice

1998 ◽  
Vol 95 (21) ◽  
pp. 12580-12585 ◽  
Author(s):  
P. Tremblay ◽  
Z. Meiner ◽  
M. Galou ◽  
C. Heinrich ◽  
C. Petromilli ◽  
...  
Keyword(s):  
Prion Protein ◽  
Prion Disease ◽  
Transgene Expression
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