Histone Deacetylase Inhibitor Romidepsin Induces HIV Expression in CD4 T Cells from Patients on Suppressive Antiretroviral Therapy at Concentrations Achieved by Clinical Dosing

Datsen George Wei; Vicki Chiang; Elizabeth Fyne; Mini Balakrishnan; Tiffany Barnes; Michael Graupe; Joseph Hesselgesser; Alivelu Irrinki; Jeffrey P. Murry; George Stepan; Kirsten M. Stray; Angela Tsai; Helen Yu; Jonathan Spindler; Mary Kearney; Celsa A. Spina; Deborah McMahon; Jacob Lalezari; Derek Sloan; John Mellors; Romas Geleziunas; Tomas Cihlar

doi:10.1371/journal.ppat.1004071

Histone Deacetylase Inhibitor Romidepsin Induces HIV Expression in CD4 T Cells from Patients on Suppressive Antiretroviral Therapy at Concentrations Achieved by Clinical Dosing

PLoS Pathogens ◽

10.1371/journal.ppat.1004071 ◽

2014 ◽

Vol 10 (4) ◽

pp. e1004071 ◽

Cited By ~ 178

Author(s):

Datsen George Wei ◽

Vicki Chiang ◽

Elizabeth Fyne ◽

Mini Balakrishnan ◽

Tiffany Barnes ◽

...

Keyword(s):

T Cells ◽

Antiretroviral Therapy ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Cd4 T Cells ◽

Deacetylase Inhibitor

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Faculty Opinions recommendation of Histone deacetylase inhibitor romidepsin induces HIV expression in CD4 T cells from patients on suppressive antiretroviral therapy at concentrations achieved by clinical dosing.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718346567.793517940 ◽

2016 ◽

Author(s):

Boris Matija Peterlin

Keyword(s):

T Cells ◽

Antiretroviral Therapy ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Cd4 T Cells ◽

Deacetylase Inhibitor

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The Histone Deacetylase Inhibitor Vorinostat (SAHA) Increases the Susceptibility of Uninfected CD4+ T Cells to HIV by Increasing the Kinetics and Efficiency of Postentry Viral Events

Journal of Virology ◽

10.1128/jvi.00320-14 ◽

2014 ◽

Vol 88 (18) ◽

pp. 10803-10812 ◽

Cited By ~ 39

Author(s):

M. B. Lucera ◽

C. A. Tilton ◽

H. Mao ◽

C. Dobrowolski ◽

C. O. Tabler ◽

...

Keyword(s):

T Cells ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Cd4 T Cells ◽

Deacetylase Inhibitor

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The histone deacetylase inhibitor ITF2357 decreases surface CXCR4 and CCR5 expression in CD4+ T-cells and monocytes and induces latent HIV-1 expression in vitro

Cytokine ◽

10.1016/j.cyto.2009.07.191 ◽

2009 ◽

Vol 48 (1-2) ◽

pp. 61

Author(s):

Shay Matalon ◽

Brent E. Palmer ◽

Marcel F. Nold ◽

Antonio Furlan ◽

Gianluca Fossati ◽

...

Keyword(s):

T Cells ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Cd4 T Cells ◽

Ccr5 Expression ◽

Deacetylase Inhibitor ◽

Latent Hiv ◽

Hiv 1

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Histone deacetylase inhibitor uses p21Cip1 to maintain anergy in CD4+ T cells

International Immunopharmacology ◽

10.1016/j.intimp.2009.07.012 ◽

2009 ◽

Vol 9 (11) ◽

pp. 1289-1297 ◽

Cited By ~ 9

Author(s):

A. Selma Dagtas ◽

R. Erik Edens ◽

Kathleen M. Gilbert

Keyword(s):

T Cells ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Cd4 T Cells ◽

Deacetylase Inhibitor

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The Histone Deacetylase Inhibitor ITF2357 Decreases Surface CXCR4 and CCR5 Expression on CD4+ T-Cells and Monocytes and is Superior to Valproic Acid for Latent HIV-1 Expression in Vitro

JAIDS Journal of Acquired Immune Deficiency Syndromes ◽

10.1097/qai.0b013e3181d3dca3 ◽

2010 ◽

Vol 54 (1) ◽

pp. 1-9 ◽

Cited By ~ 58

Author(s):

Shay Matalon ◽

Brent E Palmer ◽

Marcel F Nold ◽

Antonio Furlan ◽

Afework Kassu ◽

...

Keyword(s):

Valproic Acid ◽

T Cells ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Cd4 T Cells ◽

Ccr5 Expression ◽

Deacetylase Inhibitor ◽

Latent Hiv ◽

Hiv 1

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A Novel Histone Deacetylase Inhibitor, AR-42, Reactivates HIV-1 from Chronically and Latently Infected CD4⁺ T-cells

Retrovirology Research and Treatment ◽

10.4137/rrt.s31632 ◽

2015 ◽

pp. 1 ◽

Cited By ~ 1

Author(s):

Jesse Kwiek ◽

Jessica Mates ◽

Suresh De Silva ◽

MArk Lustberg ◽

Kelsey Van Deusen ◽

...

Keyword(s):

T Cells ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Cd4 T Cells ◽

Deacetylase Inhibitor ◽

Latently Infected ◽

Hiv 1

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Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trial

The Lancet HIV ◽

10.1016/s2352-3018(14)70014-1 ◽

2014 ◽

Vol 1 (1) ◽

pp. e13-e21 ◽

Cited By ~ 358

Author(s):

Thomas A Rasmussen ◽

Martin Tolstrup ◽

Christel R Brinkmann ◽

Rikke Olesen ◽

Christian Erikstrup ◽

...

Keyword(s):

Clinical Trial ◽

Antiretroviral Therapy ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Phase 1 ◽

Latent Virus ◽

Virus Reactivation ◽

Single Group ◽

Deacetylase Inhibitor

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Genome-Wide Histone Acetylation Profiling of Herpesvirus saimiri in Human T Cells upon Induction with a Histone Deacetylase Inhibitor

Journal of Virology ◽

10.1128/jvi.00164-11 ◽

2011 ◽

Vol 85 (11) ◽

pp. 5456-5464 ◽

Cited By ~ 7

Author(s):

B. Alberter ◽

B. Vogel ◽

D. Lengenfelder ◽

F. Full ◽

A. Ensser

Keyword(s):

T Cells ◽

Histone Acetylation ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Herpesvirus Saimiri ◽

Genome Wide ◽

Human T Cells ◽

Deacetylase Inhibitor

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Histone Deacetylase Inhibitor Modulates NKG2D Receptor Expression and Memory Phenotype of Human Gamma/Delta T Cells Upon Interaction With Tumor Cells

Frontiers in Immunology ◽

10.3389/fimmu.2019.00569 ◽

2019 ◽

Vol 10 ◽

Cited By ~ 7

Author(s):

Jaydeep Bhat ◽

Samuel Dubin ◽

Alexandra Dananberg ◽

Elgar Susanne Quabius ◽

Juergen Fritsch ◽

...

Keyword(s):

T Cells ◽

Tumor Cells ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Receptor Expression ◽

Gamma Delta T Cells ◽

Gamma Delta ◽

Memory Phenotype ◽

Deacetylase Inhibitor ◽

Nkg2d Receptor

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Abstract 643: The histone deacetylase inhibitor Quisinostat augments the anti-tumor reponses of T-cells: Implications in adoptive cell therapy

10.1158/1538-7445.am2014-643 ◽

2014 ◽

Author(s):

David M. Woods ◽

Andressa L. Sodre ◽

Jason B. Brayer ◽

Eduardo M. Sotomayor

Keyword(s):

T Cells ◽

Cell Therapy ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Adoptive Cell Therapy ◽

Deacetylase Inhibitor

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