scholarly journals Upregulation of Retinal Dehydrogenase 2 in Alternatively Activated Macrophages during Retinoid-dependent Type-2 Immunity to Helminth Infection in Mice

2012 ◽  
Vol 8 (8) ◽  
pp. e1002883 ◽  
Author(s):  
Mara J. Broadhurst ◽  
Jacqueline M. Leung ◽  
K. C. Lim ◽  
Natasha M. Girgis ◽  
Uma Mahesh Gundra ◽  
...  
Keyword(s):  
Helminth Infection ◽  
Activated Macrophages ◽  
Alternatively Activated Macrophages ◽  
Type 2 Immunity ◽  
Retinal Dehydrogenase ◽  
Dependent Type ◽  
Alternatively Activated

scholarly journals Similarity and Diversity in Macrophage Activation by Nematodes, Trematodes, and Cestodes

2010 ◽  
Vol 2010 ◽  
pp. 1-14 ◽  
Author(s):  
Stephen J. Jenkins ◽  
Judith E. Allen
Keyword(s):  
Macrophage Activation ◽  
Helminth Infection ◽  
Current Knowledge ◽  
Host Tissue ◽  
Macrophage Phenotype ◽  
Activated Macrophages ◽  
Alternatively Activated Macrophages ◽  
Helminth Infections ◽  
Host Metabolism ◽  
Alternatively Activated

This review summarizes current knowledge of macrophages in helminth infections, with a focus not only on delineating the striking similarities in macrophage phenotype between diverse infections but also on highlighting the differences. Findings from many different labs illustrate that macrophages in helminth infection can act as anti-parasite effectors but can also act as powerful immune suppressors. The specific role for their alternative (Th2-mediated) activation in helminth killing or expulsion versus immune regulation remains to be determined. Meanwhile, the rapid growth in knowledge of alternatively activated macrophages will require an even more expansive view of their potential functions to include repair of host tissue and regulation of host metabolism.

scholarly journals Group-2 innate lymphoid cell-dependent regulation of tissue neutrophil migration by alternatively activated macrophage-secreted Ear11

2020 ◽  
Vol 14 (1) ◽  
pp. 26-37 ◽  
Author(s):  
Veera Panova ◽  
Mayuri Gogoi ◽  
Noe Rodriguez-Rodriguez ◽  
Meera Sivasubramaniam ◽  
Helen E. Jolin ◽  
...  
Keyword(s):  
Neutrophil Migration ◽  
Neutrophil Infiltration ◽  
Rnase A ◽  
Activated Macrophages ◽  
Mucus Production ◽  
Alternatively Activated Macrophages ◽  
Group 2 ◽  
Classically Activated Macrophages ◽  
Alternatively Activated

AbstractType-2 immunity is characterised by interleukin (IL)-4, IL-5 and IL-13, eosinophilia, mucus production, IgE, and alternatively activated macrophages (AAM). However, despite the lack of neutrophil chemoattractants such as CXCL1, neutrophils, a feature of type-1 immunity, are observed in type-2 responses. Consequently, alternative mechanisms must exist to ensure that neutrophils can contribute to type-2 immune reactions without escalation of deleterious inflammation. We now demonstrate that type-2 immune-associated neutrophil infiltration is regulated by the mouse RNase A homologue, eosinophil-associated ribonuclease 11 (Ear11), which is secreted by AAM downstream of IL-25-stimulated ILC2. Transgenic overexpression of Ear11 resulted in tissue neutrophilia, whereas Ear11-deficient mice have fewer resting tissue neutrophils, whilst other type-2 immune responses are not impaired. Notably, administration of recombinant mouse Ear11 increases neutrophil motility and recruitment. Thus, Ear11 helps maintain tissue neutrophils at homoeostasis and during type-2 reactions when chemokine-producing classically activated macrophages are infrequently elicited.

scholarly journals Alternatively Activated Macrophages in Intestinal Helminth Infection: Effects on Concurrent Bacterial Colitis

2007 ◽  
Vol 179 (7) ◽  
pp. 4721-4731 ◽  
Author(s):  
Meiqian Weng ◽  
Deke Huntley ◽  
I-Fei Huang ◽  
Ondulla Foye-Jackson ◽  
Lijian Wang ◽  
...  
Keyword(s):  
Helminth Infection ◽  
Intestinal Helminth ◽  
Activated Macrophages ◽  
Alternatively Activated Macrophages ◽  
Alternatively Activated

Alternatively activated macrophages in intestinal helminth infection

2007 ◽  
Vol 13 (supplement) ◽  
pp. 644
Author(s):  
M Weng ◽  
D Huntley ◽  
O Foye-Jackson ◽  
J Wang ◽  
W Walker ◽  
...  
Keyword(s):  
Helminth Infection ◽  
Intestinal Helminth ◽  
Activated Macrophages ◽  
Alternatively Activated Macrophages ◽  
Alternatively Activated

scholarly journals Alternatively Activated Macrophages Elicited by Helminth Infection Can Be Reprogrammed to Enable Microbial Killing

2009 ◽  
Vol 182 (5) ◽  
pp. 3084-3094 ◽  
Author(s):  
Katie J. Mylonas ◽  
Meera G. Nair ◽  
Lidia Prieto-Lafuente ◽  
Daniel Paape ◽  
Judith E. Allen
Keyword(s):  
Helminth Infection ◽  
Activated Macrophages ◽  
Alternatively Activated Macrophages ◽  
Alternatively Activated

scholarly journals Th2 Immune Responses and Alternatively Activated Macrophages (AAMacs) in Helminth Infection in Aged Mice

2011 ◽  
Vol 73 (4) ◽  
pp. 511-516 ◽  
Author(s):  
Yasuhiro SUGAWARA ◽  
Noritsugu AZUMA ◽  
Sachi ONODERA ◽  
Yuichi TSUNOKA ◽  
Motoko MORIMOTO
Keyword(s):  
Immune Responses ◽  
Helminth Infection ◽  
Activated Macrophages ◽  
Alternatively Activated Macrophages ◽  
Aged Mice ◽  
Alternatively Activated

scholarly journals Ablation of NK Cell Function During Tumor Growth Favors Type 2-Associated Macrophages, Leading to Suppressed CTL Generation

2003 ◽  
Vol 10 (2-4) ◽  
pp. 71-81 ◽  
Author(s):  
Anja B. Geldhof ◽  
Jo A. van Ginderachter ◽  
Yuanqing Liu ◽  
Wim Noël ◽  
Patrick de Baetselier
Keyword(s):  
Nk Cells ◽  
Cell Function ◽  
Nk Cell ◽  
Activated Macrophages ◽  
Alternatively Activated Macrophages ◽  
Accessory Function ◽  
Alternatively Activated

Several reports describe regulatory interactions between NK cells and CTLs. We addressed the issue of NK participation in the early anti-tumor defense by inoculating α-ASGM-1 treated mice with BW-Sp3 T lymphoma. Rejection of BW-Sp3 depends on strong CTL responses. Our results demonstrated that (i) NK cells are a prerequisite for efficient CTL generation and (ii) the absence of NK cells favors the outgrowth of alternatively activated macrophages that can suppress CTL restimulation.In vitrostudies demonstrate that in splenic cultures from NK-deficient, tumor-bearing mice, the presence of alternatively activated macrophages correlates with a lack of Type 1 cytokines, while the production of Type 2 cytokines is promoted. Provision of the Type 1 cytokine, IFN-γ can boost overall CTL activity but does not revert the dominance of arginase producing adherent cells in the NK-deficient CTL cultures. The role of NK effector functions in the efficient switch of the immune system towards Type 1 activation was evaluated in cytotoxicity assays. The results indicate that the accessory function of NK can depend at least partially on their ability to preferentially engage arginase-producing cells, suggesting that NK/macrophage lytic interactions might be involved in the switch from Type 2 to Type 1-dependent immune responses.

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