scholarly journals Critical Role of Perforin-dependent CD8+ T Cell Immunity for Rapid Protective Vaccination in a Murine Model for Human Smallpox

2012 ◽  
Vol 8 (3) ◽  
pp. e1002557 ◽  
Author(s):  
Melanie Kremer ◽  
Yasemin Suezer ◽  
Asisa Volz ◽  
Theresa Frenz ◽  
Monir Majzoub ◽  
...  
Keyword(s):  
T Cell ◽  
Murine Model ◽  
Critical Role ◽  
Cd8 T Cell ◽  
T Cell Immunity ◽  
Cell Immunity ◽  
Protective Vaccination

scholarly journals On the Role of Melanoma-Specific CD8+ T-Cell Immunity in Disease Progression of Advanced-Stage Melanoma Patients

2004 ◽  
Vol 10 (14) ◽  
pp. 4754-4760 ◽  
Author(s):  
Monique van Oijen ◽  
Adriaan Bins ◽  
Sjoerd Elias ◽  
Johan Sein ◽  
Pauline Weder ◽  
...  
Keyword(s):  
T Cell ◽  
Disease Progression ◽  
Cd8 T Cell ◽  
T Cell Immunity ◽  
Advanced Stage ◽  
Cell Immunity ◽  
Melanoma Patients

scholarly journals DC-Based Vaccines for Cancer Immunotherapy

Vaccines ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 706
Author(s):  
Chunmei Fu ◽  
Li Zhou ◽  
Qing-Sheng Mi ◽  
Aimin Jiang
Keyword(s):  
Clinical Trials ◽  
T Cells ◽  
Dendritic Cells ◽  
T Cell ◽  
Cd8 T Cells ◽  
Critical Role ◽  
Cd8 T Cell ◽  
T Cell Immunity ◽  
Cell Responses ◽  
Cell Immunity

As the sentinels of the immune system, dendritic cells (DCs) play a critical role in initiating and regulating antigen-specific immune responses. Cross-priming, a process that DCs activate CD8 T cells by cross-presenting exogenous antigens onto their MHCI (Major Histocompatibility Complex class I), plays a critical role in mediating CD8 T cell immunity as well as tolerance. Current DC vaccines have remained largely unsuccessful despite their ability to potentiate both effector and memory CD8 T cell responses. There are two major hurdles for the success of DC-based vaccines: tumor-mediated immunosuppression and the functional limitation of the commonly used monocyte-derived dendritic cells (MoDCs). Due to their resistance to tumor-mediated suppression as inert vesicles, DC-derived exosomes (DCexos) have garnered much interest as cell-free therapeutic agents. However, current DCexo clinical trials have shown limited clinical benefits and failed to generate antigen-specific T cell responses. Another exciting development is the use of naturally circulating DCs instead of in vitro cultured DCs, as clinical trials with both human blood cDC2s (type 2 conventional DCs) and plasmacytoid DCs (pDCs) have shown promising results. pDC vaccines were particularly encouraging, especially in light of promising data from a recent clinical trial using a human pDC cell line, despite pDCs being considered tolerogenic and playing a suppressive role in tumors. However, how pDCs generate anti-tumor CD8 T cell immunity remains poorly understood, thus hindering their clinical advance. Using a pDC-targeted vaccine model, we have recently reported that while pDC-targeted vaccines led to strong cross-priming and durable CD8 T cell immunity, cross-presenting pDCs required cDCs to achieve cross-priming in vivo by transferring antigens to cDCs. Antigen transfer from pDCs to bystander cDCs was mediated by pDC-derived exosomes (pDCexos), which similarly required cDCs for cross-priming of antigen-specific CD8 T cells. pDCexos thus represent a new addition in our arsenal of DC-based cancer vaccines that would potentially combine the advantage of pDCs and DCexos.

scholarly journals Role of B Cells in Mucosal Vaccine–Induced Protective CD8+ T Cell Immunity against Pulmonary Tuberculosis

2015 ◽  
Vol 195 (6) ◽  
pp. 2900-2907 ◽  
Author(s):  
Amandeep K. Khera ◽  
Sam Afkhami ◽  
Rocky Lai ◽  
Mangalakumari Jeyanathan ◽  
Anna Zganiacz ◽  
...  
Keyword(s):  
T Cell ◽  
B Cells ◽  
Pulmonary Tuberculosis ◽  
Cd8 T Cell ◽  
T Cell Immunity ◽  
Mucosal Vaccine ◽  
Cell Immunity

scholarly journals Critical role of protein glycosylation in T cell immunity/autoimmunity

2010 ◽  
Vol 69 (Suppl 2) ◽  
pp. A71-A72 ◽  
Author(s):  
T G Szabo ◽  
R Palotai ◽  
P Antal ◽  
I Tokatly ◽  
L Tothfalusi ◽  
...  
Keyword(s):  
T Cell ◽  
Critical Role ◽  
Protein Glycosylation ◽  
T Cell Immunity ◽  
Cell Immunity

scholarly journals STAT5 and CD4+ T Cell Immunity

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 32 ◽  
Author(s):  
David L. Owen ◽  
Michael A. Farrar
Keyword(s):  
T Cell ◽  
Regulatory T Cell ◽  
Critical Role ◽  
Cell Types ◽  
T Cell Immunity ◽  
T Cell Subsets ◽  
Cd4 T Cell ◽  
Cell Immunity ◽  
And Function

STAT5 plays a critical role in the development and function of many cell types. Here, we review the role of STAT5 in the development of T lymphocytes in the thymus and its subsequent role in the differentiation of distinct CD4+ helper and regulatory T-cell subsets.

The pivotal role of target cells in modulating efficacy of antiviral CD8 T cell immunity in the liver

2019 ◽  
Author(s):  
A Schneider ◽  
K Manske ◽  
P Mutz ◽  
M Laschinger ◽  
R Bartenschlager ◽  
...  
Keyword(s):  
T Cell ◽  
Cd8 T Cell ◽  
T Cell Immunity ◽  
Pivotal Role ◽  
Target Cells ◽  
Cell Immunity

Role of CD8+T-cell immunity in influenza infection: potential use in future vaccine development

2009 ◽  
Vol 3 (5) ◽  
pp. 523-537 ◽  
Author(s):  
Nicole La Gruta ◽  
Anne Kelso ◽  
Lorena E Brown ◽  
Wiesan Chen ◽  
David C Jackson ◽  
...  
Keyword(s):  
T Cell ◽  
Vaccine Development ◽  
Influenza Infection ◽  
Cd8 T Cell ◽  
T Cell Immunity ◽  
Cell Immunity ◽  
Potential Use
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