scholarly journals A Temporal Role Of Type I Interferon Signaling in CD8+ T Cell Maturation during Acute West Nile Virus Infection

2011 ◽  
Vol 7 (12) ◽  
pp. e1002407 ◽  
Author(s):  
Amelia K. Pinto ◽  
Stephane Daffis ◽  
James D. Brien ◽  
Maria D. Gainey ◽  
Wayne M. Yokoyama ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Virus Infection ◽  
Type I Interferon ◽  
West Nile Virus Infection ◽  
Cd8 T Cell ◽  
Cell Maturation ◽  
Type I ◽  
Interferon Signaling ◽  
T Cell Maturation

scholarly journals Protection against West Nile Virus Infection in Mice after Inoculation with Type I Interferon-Inducing RNA Transcripts

PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e49494 ◽  
Author(s):  
Miguel Rodríguez-Pulido ◽  
Miguel A. Martín-Acebes ◽  
Estela Escribano-Romero ◽  
Ana-Belén Blázquez ◽  
Francisco Sobrino ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Virus Infection ◽  
Type I Interferon ◽  
West Nile Virus Infection ◽  
Type I ◽  
West Nile ◽  
Rna Transcripts

scholarly journals Late stages of T cell maturation in the thymus involve NF-κB and tonic type I interferon signaling

2016 ◽  
Vol 17 (5) ◽  
pp. 565-573 ◽  
Author(s):  
Yan Xing ◽  
Xiaodan Wang ◽  
Stephen C Jameson ◽  
Kristin A Hogquist
Keyword(s):  
T Cell ◽  
Type I Interferon ◽  
Cell Maturation ◽  
Type I ◽  
Interferon Signaling ◽  
T Cell Maturation ◽  
Late Stages

WEST NILE VIRUS INFECTION OF PRIMARY MOUSE NEURONAL AND NEUROGLIAL CELLS: THE ROLE OF ASTROCYTES IN CHRONIC INFECTION

2006 ◽  
Vol 75 (4) ◽  
pp. 691-696 ◽  
Author(s):  
JOSE A. P. DINIZ ◽  
HILDA GUZMAN ◽  
VSEVOLOD L. POPOV ◽  
PEDRO F. C. VASCONCELOS ◽  
FANGLING XU ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Virus Infection ◽  
Chronic Infection ◽  
West Nile Virus Infection ◽  
West Nile ◽  
Primary Mouse

scholarly journals Early Production of Type I Interferon during West Nile Virus Infection: Role for Lymphoid Tissues in IRF3-Independent Interferon Production

2007 ◽  
Vol 81 (17) ◽  
pp. 9100-9108 ◽  
Author(s):  
Nigel Bourne ◽  
Frank Scholle ◽  
Maria Carlan Silva ◽  
Shannan L. Rossi ◽  
Nathan Dewsbury ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Type I Interferon ◽  
High Titer ◽  
West Nile Virus Infection ◽  
Lymphoid Tissues ◽  
Genome Replication ◽  
Type I ◽  
West Nile

ABSTRACT Infection of cells with flaviviruses in vitro is reduced by pretreatment with small amounts of type I interferon (IFN-α/β). Similarly, pretreatment of animals with IFN and experiments using mice defective in IFN signaling have indicated a role for IFN in controlling flavivirus disease in vivo. These data, along with findings that flavivirus-infected cells block IFN signaling, suggest that flavivirus infection can trigger an IFN response. To investigate IFN gene induction by the very first cells infected during in vivo infection with the flavivirus West Nile virus (WNV), we infected mice with high-titer preparations of WNV virus-like particles (VLPs), which initiate viral genome replication in cells but fail to spread. These studies demonstrated a brisk production of IFN in vivo, with peak levels of over 1,000 units/ml detected in sera between 8 and 24 h after inoculation by either the intraperitoneal or footpad route. The IFN response was dependent on genome replication, and WNV genomes and WNV antigen-positive cells were readily detected in the popliteal lymph nodes (pLN) of VLP-inoculated mice. High levels of IFN mRNA transcripts and functional IFN were also produced in VLP-inoculated IFN regulatory factor 3 null (IRF3−/−) mice, indicating that IFN production was independent of the IRF3 pathways to IFN gene transcription, consistent with the IFN type produced (predominantly α).

scholarly journals Genetic Variants and Susceptibility to Neurological Complications Following West Nile Virus Infection

2011 ◽  
Vol 204 (7) ◽  
pp. 1031-1037 ◽  
Author(s):  
Mark Loeb ◽  
Sasha Eskandarian ◽  
Mark Rupp ◽  
Neil Fishman ◽  
Leanne Gasink ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Virus Infection ◽  
Genetic Variants ◽  
Statistical Significance ◽  
West Nile Virus Infection ◽  
Neurological Complications ◽  
Type I ◽  
Nucleotide Polymorphisms ◽  
West Nile ◽  
Α Subunit

Abstract To determine genetic factors predisposing to neurological complications following West Nile virus infection, we analyzed a cohort of 560 neuroinvasive case patients and 950 control patients for 13 371 mostly nonsynonymous single-nucleotide polymorphisms (SNPs). The top 3 SNPs on the basis of statistical significance were also in genes of biological plausibility: rs2066786 in RFC1 (replication factor C1) (P = 1.88 × 10−5; odds ratio [OR], 0.68 [95% confidence interval {CI}, .56–.81]); rs2298771 in SCN1A (sodium channel, neuronal type I α subunit) (P = 5.87 × 10−5; OR, 1.47 [95% CI, 1.21–1.77]); and rs25651 in ANPEP (ananyl aminopeptidase) (P = 1.44 × 10−4; OR, 0.69 [95% CI, .56–.83]). Additional genotyping of these SNPs in a separate sample of 264 case patients and 296 control patients resulted in a lack of significance in the replication cohort; joint significance was as follows: rs2066786, P = .0022; rs2298771, P = .005; rs25651, P = .042. Using mostly nonsynonymous variants, we therefore did not identify genetic variants associated with neuroinvasive disease.

scholarly journals Defining the Role of Type I Interferon Signaling in the Increased Accumulation of Versican in Lungs of Mice Exposed to Influenza Infection

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Jourdan Brune ◽  
Mary Chang ◽  
Jessica Felgenhauer ◽  
Brian Johnson ◽  
Megan Larmore ◽  
...  
Keyword(s):  
Type I Interferon ◽  
Influenza Infection ◽  
Type I ◽  
Interferon Signaling

scholarly journals Mouse Model of SARS-CoV-2 Reveals Inflammatory Role of Type I Interferon Signaling

2020 ◽  
Author(s):  
Benjamin Goldman-Israelow ◽  
Eric Song ◽  
Tianyang Mao ◽  
Peiwen Lu ◽  
Amit Meir ◽  
...  
Keyword(s):  
Mouse Model ◽  
Type I Interferon ◽  
Type I ◽  
Interferon Signaling
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