scholarly journals HCMV Spread and Cell Tropism are Determined by Distinct Virus Populations

2011 ◽  
Vol 7 (1) ◽  
pp. e1001256 ◽  
Author(s):  
Laura Scrivano ◽  
Christian Sinzger ◽  
Hans Nitschko ◽  
Ulrich H. Koszinowski ◽  
Barbara Adler
Keyword(s):  
Cell Tropism ◽  
Distinct Virus

scholarly journals Unresolved advantages of multipartitism in spatially structured environments

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Mark P Zwart ◽  
Stéphane Blanc ◽  
Marcelle Johnson ◽  
Susanna Manrubia ◽  
Yannis Michalakis ◽  
...  
Keyword(s):  
Genome Organization ◽  
Latent Infection ◽  
Virus Transmission ◽  
Plant Viruses ◽  
Epidemic Spread ◽  
Virus Particles ◽  
Distinct Virus ◽  
Network Epidemiology ◽  
Short Commentary ◽  
Animal Hosts

Abstract Multipartite viruses have segmented genomes and package each of their genome segments individually into distinct virus particles. Multipartitism is common among plant viruses, but why this apparently costly genome organization and packaging has evolved remains unclear. Recently Zhang and colleagues developed network epidemiology models to study the epidemic spread of multipartite viruses and their distribution over plant and animal hosts (Phys. Rev. Lett. 2019, 123, 138101). In this short commentary, we call into question the relevance of these results because of key model assumptions. First, the model of plant hosts assumes virus transmission only occurs between adjacent plants. This assumption overlooks the basic but imperative fact that most multipartite viruses are transmitted over variable distances by mobile animal vectors, rendering the model results irrelevant to differences between plant and animal hosts. Second, when not all genome segments of a multipartite virus are transmitted to a host, the model assumes an incessant latent infection occurs. This is a bold assumption for which there is no evidence to date, making the relevance of these results to understanding multipartitism questionable.

scholarly journals SARS-CoV-2 cell tropism and multiorgan infection

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Jia Liu ◽  
Yufeng Li ◽  
Qian Liu ◽  
Qun Yao ◽  
Xi Wang ◽  
...  
Keyword(s):  
Cell Tropism

scholarly journals Identification of the Envelope V3 Loop as a Determinant of a CD4-Negative Neuronal Cell Tropism for HIV-1

Virology ◽  
1996 ◽  
Vol 217 (2) ◽  
pp. 613-617 ◽  
Author(s):  
J.ROBERTO TRUJILLO ◽  
WEI-KUNG WANG ◽  
TUN-HOU LEE ◽  
MAX ESSEX
Keyword(s):  
Neuronal Cell ◽  
V3 Loop ◽  
Cell Tropism ◽  
Hiv 1

Mechanisms of transcriptional synergism between distinct virus-inducible enhancer elements

Cell ◽  
1993 ◽  
Vol 74 (5) ◽  
pp. 887-898 ◽  
Author(s):  
Wei Du ◽  
Dimitris Thanos ◽  
Tom Maniatis
Keyword(s):  
Distinct Virus

scholarly journals Cell tropism of wild-type measles virus is affected by amino acid substitutions in the P, V and M proteins, or by a truncation in the C protein

2004 ◽  
Vol 85 (10) ◽  
pp. 3001-3006 ◽  
Author(s):  
Naoko Miyajima ◽  
Makoto Takeda ◽  
Masato Tashiro ◽  
Koji Hashimoto ◽  
Yusuke Yanagi ◽  
...  
Keyword(s):  
Amino Acid ◽  
Measles Virus ◽  
M Protein ◽  
Amino Acid Difference ◽  
Cell Tropism ◽  
Wild Type ◽  
M Gene ◽  
Nucleotide Difference ◽  
Virus Growth ◽  
C Protein

Two nucleotide differences in the P/C/V and M genes between B95a cell- and Vero cell-isolated wild-type measles viruses (MV) have previously been found from the same patient. The nucleotide difference in the P/C/V gene resulted in an amino acid difference (M175I) in the P and V proteins and a 19 aa deletion in the C protein. The nucleotide difference in the M gene resulted in an amino acid difference (P64H) in the M protein. To verify this result and to examine further whether the amino acid difference or truncation is important for MV cell tropism, recombinant MV strains containing one of the two nucleotide substitutions, or both, were generated. It was found that the P64H substitution in the M protein was important for efficient virus growth and dissemination in Vero cells and that the M175I substitution in the P and V protein or truncation of the C protein was required for optimal growth.

Cell tropism and entry of porcine circovirus 2

2012 ◽  
Vol 164 (1-2) ◽  
pp. 43-45 ◽  
Author(s):  
H.J. Nauwynck ◽  
R. Sanchez ◽  
P. Meerts ◽  
D.J. Lefebvre ◽  
D. Saha ◽  
...  
Keyword(s):  
Porcine Circovirus ◽  
Cell Tropism ◽  
Porcine Circovirus 2
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