scholarly journals Sex-differences in circulating biomarkers during acute myocardial infarction: An analysis from the SWEDEHEART registry

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0249830
Author(s):  
Kai M. Eggers ◽  
Lars Lindhagen ◽  
Tomasz Baron ◽  
David Erlinge ◽  
Marcus Hjort ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Sex Differences ◽  
Multiple Testing ◽  
Plaque Rupture ◽  
Multiple Reaction Monitoring ◽  
Myocardial Necrosis ◽  
Myocardial Damage ◽  
Circulating Biomarkers ◽  
High Discrimination ◽  
Penalized Logistic Regression

Background Sex-differences in the pathobiology of myocardial infarction are well established but incompletely understood. Improved knowledge on this topic may help clinicians to improve management of men and women with myocardial infarction. Methods In this registry-based cohort study (SWEDEHEART), we analyzed 175 circulating biomarkers reflecting various pathobiological axes in 856 men and 243 women admitted to Swedish coronary care units because of myocardial infarction. Two multimarker panels were applied (Proximity Extension Assay [Olink Bioscience], Multiple Reaction Monitoring mass spectrometry). Lasso analysis (penalized logistic regression), multiple testing-corrected Mann-Whitney tests and Cox regressions were used to assess sex-differences in the concentrations of these biomarkers and their implications on all-cause mortality and major adverse events (median follow-up up to 6.6 years). Results Biomarkers provided a very high discrimination between both sexes, when considered simultaneously (c-statistics 0.972). Compared to women, men had higher concentrations of six biomarkers with the most pronounced differences seen for those reflecting atherogenesis, myocardial necrosis and metabolism. Women had higher concentrations of 14 biomarkers with the most pronounced differences seen for those reflecting activation of the renin-angiotensin-aldosterone axis, inflammation and for adipokines. There were no major variations between sexes in the associations of these biomarkers with outcome. Conclusions Severable sex-differences exist in the expression of biomarkers in patients with myocardial infarction. While these differences had no impact on outcome, our data suggest the presence of various sex-related pathways involved in the development of coronary atherosclerosis, the progression to plaque rupture and acute myocardial damage, with a greater heterogeneity in women.

scholarly journals PERIPROCEDURAL MYOCARDIAL DAMAGE

2013 ◽  
Vol 12 (1) ◽  
pp. 95-101
Author(s):  
S. A. Akinina
Keyword(s):  
Myocardial Infarction ◽  
Coronary Heart Disease ◽  
Myocardial Necrosis ◽  
Myocardial Damage ◽  
High Sensitivity ◽  
Coronary Intervention ◽  
Success Rates ◽  
Myocardial Revascularisation ◽  
Percutaneous Coronary ◽  
Periprocedural Myocardial Infarction

Percutaneous coronary intervention (PCI), as a method of myocardial revascularisation, is widely and effectively used for the treatment of coronary heart disease (CHD), with immediate success rates of >90%. Depending on the diagnostic criteria, 5–30% of these patients could develop the signs of periprocedural myocardial damage (PMD) or periprocedural myocardial infarction (PMI). PMD predictors, mechanisms of PMD development, and its specific clinical features play an important role in the PMI prevention. At present, there is no universal agreement on the definition and diagnostics of periprocedural myocardial necrosis and PMI, or on their impact on the clinical outcomes. According to the results of the recent studies, which are presented in this review, the current criteria of PMI might need to be modified, due to the increasingly high sensitivity of the modern threshold levels of troponin. 

scholarly journals Unusual case of myocardial injury induced by Escherichia coli sepsis

2015 ◽  
Vol 74 (1) ◽  
Author(s):  
Gaetano Gentile ◽  
Ester Meles ◽  
Claudio Carbone ◽  
Edoardo Cantù ◽  
Stefano Maggiolini
Keyword(s):  
Myocardial Infarction ◽  
Escherichia Coli ◽  
Myocardial Injury ◽  
Unusual Case ◽  
Myocardial Necrosis ◽  
Myocardial Damage ◽  
Bacterial Sepsis ◽  
Ecg Changes ◽  
Electrocardiogram Ecg ◽  
Symptoms And Signs

The typical symptoms and signs of myocardial infarction are well known. Alterations in electrocardiogram (ECG), echocardiography or biochemical markers of myocardial necrosis are usually helpful to confirm the diagnosis. Some of these features, however, also occur in myocarditis, which is a potential differential diagnosis. We describe an unusual case of bacterial sepsis due to Escherichia coli that caused myocardial damage (myocarditis) with ECG changes mimicking acute myocardial infarction. The possible pathophysiological mechanisms of myocardial injury in sepsis are also reviewed.

Creatine kinase and lactate dehydrogenase isoenzymes in serum of patients suffering burns, blunt trauma, or myocardial infarction.

1984 ◽  
Vol 30 (8) ◽  
pp. 1332-1338 ◽  
Author(s):  
S Shahangian ◽  
K O Ash ◽  
N O Wahlstrom ◽  
G D Warden ◽  
J R Saffle ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Creatine Kinase ◽  
Lactate Dehydrogenase ◽  
Blunt Trauma ◽  
Electrical Contact ◽  
Myocardial Necrosis ◽  
Myocardial Damage ◽  
Trauma Patients ◽  
Creatine Kinase Mb ◽  
Myocardial Involvement

Abstract Medical records of 53 burn and trauma patients were reviewed to assess the possibility of myocardial damage. Except for electrophoretically detectable creatine kinase MB isoenzyme, none showed evidence of myocardial injury. Lactate dehydrogenase isoenzyme tests, electrocardiograms, myocardial pyrophosphate scans, clinical course, and results of (two) autopsies were all negative for myocardial necrosis or ischemia. Types of patient, number, mean peak value (U/L) for serum creatine kinase, and ranges of percentage MB isoenzyme were as follows. Burns from direct electrical contact: 28, 16 600, 0-29; electrical flash or other thermal burns: 10, 4340, 0-22; blunt trauma (mostly from automobile accidents): 15, 3430, 0-18; myocardial infarction: 57, 1520, 4-46. Evidently creatine kinase MB isoenzyme is nonspecific in burn and trauma patients and should not be the only test result used to assess myocardial involvement.

Smoking, Serum Lipids, Blood Pressure, and Sex Differences in Myocardial Infarction

Circulation ◽  
1996 ◽  
Vol 93 (3) ◽  
pp. 450-456 ◽  
Author(s):  
Inger Njølstad ◽  
Egil Arnesen ◽  
Per G. Lund-Larsen
Keyword(s):  
Myocardial Infarction ◽  
Blood Pressure ◽  
Sex Differences ◽  
Serum Lipids
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