scholarly journals Trends in US pediatric mental health clinical trials: An analysis of ClinicalTrials.gov from 2007–2018

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0248898
Author(s):  
Joshua R. Wortzel ◽  
Brandon E. Turner ◽  
Brannon T. Weeks ◽  
Christopher Fragassi ◽  
Virginia Ramos ◽  
...  
Keyword(s):  
Mental Health ◽  
Clinical Trials ◽  
Clinical Research ◽  
Mental Health Research ◽  
Funding Source ◽  
Annual Growth Rate ◽  
Compound Annual Growth Rate ◽  
The Past ◽  
Us Government ◽  
Pediatric Mental Health

Whereas time trends in the epidemiologic burden of US pediatric mental health disorders are well described, little is known about trends in how these disorders are studied through clinical research. We identified how funding source, disorders studied, treatments studied, and trial design changed over the past decade in US pediatric mental health clinical trials. We identified all US pediatric interventional mental health trials submitted to ClinicalTrials.gov between October 1, 2007 and April 30, 2018 (n = 1,019) and manually characterized disorders and treatments studied. We assessed trial growth and design characteristics by funding source, treatments, and disorders. US pediatric mental health trials grew over the past decade (compound annual growth rate [CAGR] 4.1%). The number of studies funded by industry and US government remained unchanged, whereas studies funded by other sources (e.g., academic medical centers) grew (CAGR 11.3%). Neurodevelopmental disorders comprised the largest proportion of disorders studied, and Non-DSM-5 (Diagnostic and Statistical Manual-5) conditions was the only disorder category to grow (14.5% to 24.6%; first half to second half of decade). There was significant growth of trials studying non-psycho/pharmacotherapy treatments (33.8% to 49.0%) and a decline in trials studying pharmacotherapies (31.7% to 20.6%), though these trends differed by funding source. There were also notable differences in funding sources and treatments studied within each disorder category. Trials using double blinding declined (26.2% to 18.0%). Limitations include that ClinicalTrials.gov is not an exhaustive list of US clinical trials, and trends identified may in part reflect changes in trial registration rather than changes in clinical research. Nevertheless, ClinicalTrials.gov is among the largest databases available for evaluating trends and patterns in pediatric mental health research that might otherwise remain unassessable. Understanding these trends can guide researchers and funding bodies when considering the trajectory of the field.

scholarly journals The psychiatric case register: noble past, challenging present, but exciting future

2009 ◽  
Vol 195 (3) ◽  
pp. 191-193 ◽  
Author(s):  
Gayan Perera ◽  
Mishael Soremekun ◽  
Gerome Breen ◽  
Robert Stewart
Keyword(s):  
Mental Health ◽  
Health Research ◽  
Mental Health Research ◽  
Case Register ◽  
Psychiatric Case Register ◽  
The Past ◽  
Technological Capacity ◽  
Psychiatric Case ◽  
Clinical Records

SummaryCase registers have been fundamental to mental health research from the early asylum studies onwards. Having declined in popularity over the past 20 years, they are likely to see a resurgence of interest with the advent of electronic clinical records and the technological capacity to derive anonymised databases from these.

Venture Capital Investment in Orthopaedics: Has the Landscape Changed over the Past Two Decades (2000–2019)?

2021 ◽  
pp. 155335062110310
Author(s):  
Thomas B. Cwalina ◽  
Tarun K. Jella ◽  
Alexander J. Acuña ◽  
Linsen T. Samuel ◽  
Atul F. Kamath
Keyword(s):  
Venture Capital ◽  
Capital Investment ◽  
Third Party ◽  
Annual Growth Rate ◽  
Capital Investments ◽  
Compound Annual Growth Rate ◽  
Venture Capital Investment ◽  
The Past ◽  
Dollar Amount ◽  
Venture Capital Investments

Background. Innovations in orthopaedic technologies often require significant funding. Although an increasing trend has been observed for third-party investments in other medical fields, no study has examined the influence of venture capital (VC) funding in orthopaedics. Therefore, this study analyzed trends in VC investments related to the field of orthopaedic surgery, as well as the characteristics of recipients of these investments. Methods. Venture capital investments into orthopaedic-related businesses were reviewed from 2000 to 2019 using Capital IQ, a proprietary intelligence platform documenting financial investments. Metrics categorized were investments by year, investment amount, and subspecialty domain as per the American Academy Orthopaedic Surgeons website. The compound annual growth rate (CAGR) for both quantity and dollar amount of investments was calculated over the study period and the two decade-long periods (2000–2009 and 2010–2019). Results. Over two decades, 673 VC investments took place, involving a total of US$3.5 billion. Both the number and dollar value of investments were greater in the second decade (440, US$1.9 billion), compared to the first decade (233, US$1.6 billion). Both quantity and dollar amount of VC investments grew over the first decade, with a CAGR 9.53% and 4.97%, respectively. However, investment growth declined in the latter decade. The largest and most frequent investments took place within spine surgery and adult reconstruction. Conclusion. An initially rising trend in VC investment in orthopaedic-related businesses may have plateaued over the past decade. These findings may have important implications for continued investment into orthopaedic innovations and collaboration between the surgical community and private sector.

scholarly journals Patient oriented research in mental health: matching laboratory to life and beyond in Canada

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Jenessa N. Johnston ◽  
Lisa Ridgway ◽  
Sarah Cary-Barnard ◽  
Josh Allen ◽  
Carla L. Sanchez-Lafuente ◽  
...  
Keyword(s):  
Mental Health ◽  
Clinical Research ◽  
Lived Experience ◽  
Health Research ◽  
Mental Health Research ◽  
Great Utility ◽  
The Future ◽  
Primary Investigator ◽  
Oriented Research

AbstractAs patient-oriented research gains popularity in clinical research, the lack of patient input in foundational science grows more evident. Research has shown great utility in active partnerships between patient partners and scientists, yet many researchers are still hesitant about listening to the voices of those with lived experience guide and shape their experiments. Mental health has been a leading area for patient movements such as survivor-led research, however the stigma experienced by these patients creates difficulties not present in other health disciplines. The emergence of COVID-19 has also created unique circumstances that need to be addressed. Through this lens, we have taken experiences from our patient partners, students, and primary investigator to create recommendations for the better facilitation of patient-oriented research in foundational science in Canada. With these guidelines, from initial recruitment and leading to sustaining meaningful partnerships, we hope to encourage other researchers that patient-oriented research is necessary for the future of mental health research and foundational science.

scholarly journals Magyar klinikai vizsgálatok sajátosságai egy nemzetközi adatbázis elemzése alapján

2017 ◽  
Vol 158 (9) ◽  
pp. 345-351
Author(s):  
Tamás Tóth ◽  
Péter Pollner ◽  
Gergely Palla ◽  
Elek Dinya
Keyword(s):  
Clinical Trials ◽  
Clinical Research ◽  
Data Cleaning ◽  
Free Text ◽  
Research Organizations ◽  
The Us ◽  
Us Government ◽  
International View ◽  
Significant Data

Abstract: Intorduction: The ClinicalTrials.gov website, which is operated by the US government, collects data about clinical trials. Aim: We have processed data related to Hungary by downloading from the website as XML files. Method: Most of the data describe trials performed after 2000, so we got an overview about the clinical research of the last 10 to 15 years. As the majority of the data fields are collected as free text, significant data cleaning was needed. Results: The database contained 2863 trials related to Hungary from 189 settlements. Only 20 per cent of the actual research organizations could have been identified as many times only an “id” number or a general name was given, thus this information was anonymised in many cases. Conclusion: Besides the analysis of the information obtained from this database, our study points out the relevant issues that may influence the international view of the Hungarian clinical research. Orv. Hetil., 2017, 158(9), 345–351.

The growth oxymoron: strategic execution

2019 ◽  
Vol 35 (6) ◽  
pp. 1-4
Author(s):  
Carol M. Connell ◽  
Christine Lemyze
Keyword(s):  
Growth Rate ◽  
Financial Crisis ◽  
Annual Growth ◽  
Annual Growth Rate ◽  
Strategy Execution ◽  
Content Type ◽  
Compound Annual Growth Rate ◽  
The Past ◽  
Strategic Execution

Purpose The purpose of this paper is to present a viewpoint on aligning strategy and execution to produce superior business results. Design/methodology/approach The paper examines the long-term financials of the top ten growers to reveal companies that have continued to grow in good economic times and bad, including the Great Recession. While some companies dug deeper into their core businesses during the financial crisis, others continued to innovate. Findings Where companies continued to focus on strategy execution, they were rewarded, for example, Amazon’s compound annual growth rate for the ten-year period that included the financial crisis was 36.45 per cent; in the past three years, Amazon’s compound annual growth rate (CAGR) has been 56.76 per cent. Most of the top ten long-term growers are headed by the same founder/entrepreneur. Research limitations/implications Look beyond the past three years for models of successful strategy execution. Practical implications For long-term company leaders, entrepreneurs, or turnaround experts, strategic execution is no oxymoron, but a requirement for growth and, ultimately, their unique responsibility. Social implications The paper identifies three major focus areas for strategy teams and company leadership: 1. customer centricity and strategy execution; 2. learning from survivors; and 3. rethinking capabilities and talent. Originality/value As a professor of strategic management and as a consultant to organizations on strategy and marketing transformation, we have focused on the activities that are necessary for leaders to create effective strategy and to execute successfully. We have also been responsible for equipping the larger teams of strategy professionals (and future strategy professionals) who support these leaders with the approaches, the methods, and the tools necessary to plan effectively, to assess effectiveness, and to correct problems in strategy and execution. We bring that perspective to this viewpoint paper.

scholarly journals Rett Syndrome: Coming to Terms with Treatment

2014 ◽  
Vol 2014 ◽  
pp. 1-20 ◽  
Author(s):  
Alan Percy
Keyword(s):  
Clinical Trials ◽  
Clinical Research ◽  
Rett Syndrome ◽  
Basic Science ◽  
Basic Research ◽  
The Past ◽  
Research Consortium ◽  
Science Investigations ◽  
Remarkable Progress ◽  
Important Progress

Rett syndrome (RTT) has experienced remarkable progress over the past three decades since emerging as a disorder of worldwide proportions, particularly with discovery of the linkage of RTT to MECP2 mutations. The advances in clinical research and the increasing pace of basic science investigations have accelerated the pattern of discovery and understanding. Clinical trials are ongoing and others are planned. A review of these events and the prospects for continued success are highlighted below. The girls and women encountered today with RTT are, overall, in better general, neurologic, and behavioral health than those encountered earlier. This represents important progress worldwide from the concerted efforts of a broadly based and diverse clinical and basic research consortium as well as the efforts of parents, family, and friends.

scholarly journals Bibliometric analysis on randomized controlled trials of colorectal cancer over the last decade

2020 ◽  
Author(s):  
Jun-hong Hu ◽  
Chen-Yu Wang ◽  
Shi-Can Zhou ◽  
Xing-Wang Li ◽  
Bing-Hui Li ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Clinical Trials ◽  
Clinical Research ◽  
Randomized Controlled Trials ◽  
Bibliometric Analysis ◽  
Controlled Trials ◽  
Research Institutions ◽  
Randomized Controlled ◽  
The Past ◽  
Surgical Methods

Abstract Background The aim of this bibliometric analysis was to evaluate the clinical trials of randomized controlled trials (RCTs) of colorectal cancer all the world over the past decade. Methods The PubMed and Web of Science database were searched to obtain a randomized controlled trial of colorectal cancer from January 1, 2008 to January 1, 2018.The included literatures were analyzed with the bibliometric analysis. Results In the past 10 years, Randomized controlled trials of colorectal cancer have shown an upward trend; Most of the top ten research institutions in the literature are from the USA, the UK and other regions which has the high incidence of colorectal cancer; Most of the related research journals are also sponsored by European and American countries; the frequently cited top 15 literatures are mostly international multi-center clinical research, and there are fewer participants in Chinese research institutions. By keyword co-occurrence, colorectal cancer research mostly involves screening, disease-free survival, drug treatment, surgical methods, clinical trials, quality of life and prognosis; The results of the co-authorship network analysis show that Chinese researchers are less involved in international cooperation. Conclusions High-quality randomized controlled trials are increasingly favored by top international journals. However, there is still a large gap in clinical research between China and abroad. Researchers should gradually implement the standardization and accuracy of clinical trials, strengthen international multi-center cooperation and emphasize quality control.

scholarly journals COVID-19 challenges in clinical trials

2021 ◽  
Vol 10 (6) ◽  
pp. 769
Author(s):  
Murugan Panchatcharam ◽  
Sravanthi Lakshmi Mukku
Keyword(s):  
Clinical Trials ◽  
Clinical Research ◽  
Human Subjects ◽  
Well Being ◽  
The Past ◽  
The Face ◽  
Current Scenario ◽  
One Year ◽  
Research Organisations ◽  
Contract Research Organisations

Clinical research involves working with human subjects to answer questions relevant to their well-being in an ethical manner. The current scenario from the past one year has drastically changed the face of the clinical trials. The present COVID prevalence and simultaneously conducting the research with all the regulations and the precautions has been the difficult task for the contract research organisations (CRO).

Developing support for mental health clinical research: the Mental Health Research Network experience

2012 ◽  
Vol 2 (5) ◽  
pp. 459-463 ◽  
Author(s):  
Patrick Callaghan ◽  
Anthony David ◽  
Shon Lewis ◽  
Max Marshall ◽  
George Szmukler ◽  
...  
Keyword(s):  
Mental Health ◽  
Clinical Research ◽  
Health Research ◽  
Mental Health Research ◽  
Research Network
Sign in / Sign up

Export Citation Format

Share Document