scholarly journals Impact of chronic liver disease upon admission on COVID-19 in-hospital mortality: Findings from COVOCA study

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243700
Author(s):  
Raffaele Galiero ◽  
Pia Clara Pafundi ◽  
Vittorio Simeon ◽  
Luca Rinaldi ◽  
Alessandro Perrella ◽  
...  
Keyword(s):  
Liver Disease ◽  
Hospital Mortality ◽  
Chronic Liver Disease ◽  
Western Country ◽  
Chronic Liver ◽  
Campania Region ◽  
Logistic Analysis ◽  
Observational Cohort ◽  
Independent Association ◽  
Clinical Conditions

Background Italy has been the first Western country to be heavily affected by the spread of SARS-COV-2 infection and among the pioneers of the clinical management of pandemic. To improve the outcome, identification of patients at the highest risk seems mandatory. Objectives Aim of this study is to identify comorbidities and clinical conditions upon admission associated with in-hospital mortality in several COVID Centers in Campania Region (Italy). Methods COVOCA is a multicentre retrospective observational cohort study, which involved 18 COVID Centers throughout Campania Region, Italy. Data were collected from patients who completed their hospitalization between March-June 2020. The endpoint was in-hospital mortality, assessed either from data at discharge or death certificate, whilst all exposure variables were collected at hospital admission. Results Among 618 COVID-19 hospitalized patients included in the study, 143 in-hospital mortality events were recorded, with a cumulative incidence of about 23%. At multivariable logistic analysis, male sex (OR 2.63, 95%CI 1.42–4.90; p = 0.001), Chronic Liver Disease (OR 5.88, 95%CI 2.39–14.46; p<0.001) and malignancies (OR 2.62, 95%CI 1.21–5.68; p = 0.015) disclosed an independent association with a poor prognosis, Glasgow Coma Scale (GCS) and Respiratory Severity Scale allowed to identify at higher mortality risk. Sensitivity analysis further enhanced these findings. Conclusion Mortality of patients hospitalized for COVID-19 appears strongly affected by both clinical conditions on admission and comorbidities. Originally, we observed a very poor outcome in subjects with a chronic liver disease, alongside with an increase of hepatic damage.

scholarly journals Combination of FIB-4 with ultrasound surface nodularity or elastography as predictors of histologic advanced liver fibrosis in chronic liver disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Maryam Moini ◽  
Fernanda Onofrio ◽  
Bettina E. Hansen ◽  
Oyedele Adeyi ◽  
Korosh Khalili ◽  
...  
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Transient Elastography ◽  
Area Under The Curve ◽  
High Specificity ◽  
Serum Markers ◽  
Chronic Liver ◽  
Alcoholic Fatty Liver ◽  
Advanced Liver Fibrosis ◽  
Independent Association

AbstractReliable and available non-invasive methods for hepatic fibrosis assessment are important in chronic liver disease (CLD). Our aim was to compare stepwise algorithms combining standard ultrasound with serum markers and transient elastography (TE) for detecting advanced fibrosis (F3-4) and cirrhosis. Retrospective single center study between 2012 and 2018 of CLD patients with biopsy, TE, blood tests, and liver ultrasound parameters of surface nodularity (SN), lobar redistribution, and hepatic vein nodularity. Our cohort included 157 patients (51.6% males), mean age 47.6 years, predominantly non-alcoholic fatty liver disease and viral hepatitis (61%), with F3-4 prevalence of 60.5%. Area under the curve for F3-4 was 0.89 for TE ≥ 9.6 kPa and 0.80 for FIB-4 > 3.25. In multivariate modeling, TE ≥ 9.6 kPa (OR 21.78) and SN (OR 3.81) had independent association with F3-4; SN (OR 5.89) and TE ≥ 10.2 kPa (OR 15.73) were independently associated with cirrhosis. Two stepwise approaches included FIB-4 followed by SN or TE; sensitivity and specificity of stepwise SN were 0.65 and 1.00, and 0.89 and 0.33 for TE ≥ 9.6 kPa, respectively. Ultrasound SN and TE were independently predictive of F3-4 and cirrhosis in our cohort. FIB-4 followed by SN had high specificity for F3-4.

scholarly journals Genetic Susceptibility to Chronic Liver Disease in Individuals from Pakistan

2020 ◽  
Vol 21 (10) ◽  
pp. 3558
Author(s):  
Asad Mehmood Raja ◽  
Ester Ciociola ◽  
Imran Nazir Ahmad ◽  
Faisal Saud Dar ◽  
Syed Muhammad Saqlan Naqvi ◽  
...  
Keyword(s):  
Liver Disease ◽  
Genetic Susceptibility ◽  
Chronic Liver Disease ◽  
Disease Risk ◽  
Protective Role ◽  
Chronic Liver ◽  
Control Group ◽  
Chi Square ◽  
Logistic Analysis ◽  
Common Genetic Variants

Chronic liver disease, with viral or non-viral etiology, is endemic in many countries and is a growing burden in Asia. Among the Asian countries, Pakistan has the highest prevalence of chronic liver disease. Despite this, the genetic susceptibility to chronic liver disease in this country has not been investigated. We performed a comprehensive analysis of the most robustly associated common genetic variants influencing chronic liver disease in a cohort of individuals from Pakistan. A total of 587 subjects with chronic liver disease and 68 healthy control individuals were genotyped for the HSD17B13 rs7261356, MBOAT7 rs641738, GCKR rs1260326, PNPLA3 rs738409, TM6SF2 rs58542926 and PPP1R3B rs4841132 variants. The variants distribution between case and control group and their association with chronic liver disease were tested by chi-square and binary logistic analysis, respectively. We report for the first time that HSD17B13 variant results in a 50% reduced risk for chronic liver disease; while MBOAT7; GCKR and PNPLA3 variants increase this risk by more than 35% in Pakistani individuals. Our genetic analysis extends the protective role of the HSD17B13 variant against chronic liver disease and disease risk conferred by the MBOAT7; GCKR and PNPLA3 variants in the Pakistani population.

scholarly journals AST to platelet ratio index for predicting the in hospital mortality in chronic liver disease patients in tertiary care hospital

2019 ◽  
Vol 10 (4) ◽  
pp. 44-48
Author(s):  
BS Nagaraja ◽  
R Madhumati ◽  
HR Avinash ◽  
KJ Umesh
Keyword(s):  
Liver Disease ◽  
Hospital Mortality ◽  
Chronic Liver Disease ◽  
Tertiary Care ◽  
Prognostic Significance ◽  
Age Distribution ◽  
Roc Curves ◽  
Chronic Liver ◽  
Care Hospital ◽  
Apri Score

Background: Liver cirrhosis is the end result of chronic liver injury. Cirrhosis of liver may progressively deteriorate from a well-compensated state to decompensated conditions. Aims and Objective: Our study aims at evaluating the AST to Platelet Ratio Index (APRI) for predicting the in-hospital mortality and also comparing APRI, MELD and albumin for predicting in hospital mortality in chronic liver disease. Materials and Methods: Data of Patients with Chronic liver disease were retrospectively reviewed. MELD and APRI scores were calculated for the patients and results from ROC curves were analysed. Results: In our study conducted on 299 patients, the age distribution was between 18-64 years with mean age of patients being 46.47+/-10.9 years, sex ratio Male: Female: 266:37 with mortality rate of 17.7%. The area under curves of ROC of APRI, MELD and Albumin are 0.63, 0.76 and 0.55. Conclusion: APRI is an independent predictor of mortality. The prognostic performance of all 3 was comparable but MELD has better prognostic significance than APRI score.

scholarly journals S1177 CPK to ALT Ratio in Patients With COVID-19 Without Known Chronic Liver Disease Is Predictive of Increased In-Hospital Mortality

2020 ◽  
Vol 115 (1) ◽  
pp. S588-S589
Author(s):  
He Qiu ◽  
Wander Praneet ◽  
Ceena Chandrabos ◽  
David Bernstein ◽  
Nitzan Roth ◽  
...  
Keyword(s):  
Liver Disease ◽  
Hospital Mortality ◽  
Chronic Liver Disease ◽  
Chronic Liver

Genetic predictors of spontaneous viral elimination or chronic liver disease in hepatitis C infection

2001 ◽  
Vol 120 (5) ◽  
pp. A7-A7
Author(s):  
S ROSS ◽  
S MASCHERETTI ◽  
H HINRICHSEN ◽  
P BUGGISCH ◽  
U FOELSCH ◽  
...  
Keyword(s):  
Liver Disease ◽  
Hepatitis C ◽  
Chronic Liver Disease ◽  
Chronic Liver ◽  
Hepatitis C Infection ◽  
Genetic Predictors
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