scholarly journals Delivery system can vary ventilatory parameters across multiple patients from a single source of mechanical ventilation

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243601
Author(s):  
Kyle K. VanKoevering ◽  
Pratyusha Yalamanchi ◽  
Catherine T. Haring ◽  
Anne G. Phillips ◽  
Stephen Lewis Harvey ◽  
...  
Keyword(s):  
Delivery System ◽  
De Novo ◽  
Peak Inspiratory Pressure ◽  
Medical Personnel ◽  
Ease Of Use ◽  
Ventilator Support ◽  
Time Space ◽  
Animal Trials ◽  
Ventilatory Parameters ◽  
Rapid Deployment

Background Current limitations in the supply of ventilators during the Covid19 pandemic have limited respiratory support for patients with respiratory failure. Split ventilation allows a single ventilator to be used for more than one patient but is not practicable due to requirements for matched patient settings, risks of cross-contamination, harmful interference between patients and the inability to individualize ventilator support parameters. We hypothesized that a system could be developed to circumvent these limitations. Methods and findings A novel delivery system was developed to allow individualized peak inspiratory pressure settings and PEEP using a pressure regulatory valve, developed de novo, and an inline PEEP ‘booster’. One-way valves, filters, monitoring ports and wye splitters were assembled in-line to complete the system and achieve the design targets. This system was then tested to see if previously described limitations could be addressed. The system was investigated in mechanical and animal trials (ultimately with a pig and sheep concurrently ventilated from the same ventilator). The system demonstrated the ability to provide ventilation across clinically relevant scenarios including circuit occlusion, unmatched physiology, and a surgical procedure, while allowing significantly different pressures to be safely delivered to each animal for individualized support. Conclusions In settings of limited ventilator availability, systems can be developed to allow increased delivery of ventilator support to patients. This enables more rapid deployment of ventilator capacity under constraints of time, space and financial cost. These systems can be smaller, lighter, more readily stored and more rapidly deployable than ventilators. However, optimizing ventilator support for patients with individualized ventilation parameters will still be dependent upon ease of use and the availability of medical personnel.

Cardiological Database Management System as a Mediator to Clinical Decision Support

1996 ◽  
Vol 35 (01) ◽  
pp. 52-58 ◽  
Author(s):  
A. Mavromatis ◽  
N. Maglaveras ◽  
A. Tsikotis ◽  
G. Pangalos ◽  
V. Ambrosiadou ◽  
...  
Keyword(s):  
Management System ◽  
Database Management ◽  
Medical Information ◽  
Object Oriented ◽  
Medical Personnel ◽  
Database Management System ◽  
Ease Of Use ◽  
Medical Database ◽  
Analysis And Design ◽  
Object Oriented Design

AbstractAn object-oriented medical database management system is presented for a typical cardiologic center, facilitating epidemiological trials. Object-oriented analysis and design were used for the system design, offering advantages for the integrity and extendibility of medical information systems. The system was developed using object-oriented design and programming methodology, the C++ language and the Borland Paradox Relational Data Base Management System on an MS-Windows NT environment. Particular attention was paid to system compatibility, portability, the ease of use, and the suitable design of the patient record so as to support the decisions of medical personnel in cardiovascular centers. The system was designed to accept complex, heterogeneous, distributed data in various formats and from different kinds of examinations such as Holter, Doppler and electrocardiography.

Towards a Broad Use of Gamification Based on Hand Tracking in Post Stroke Patients

2019 ◽  
Author(s):  
Daniele Regazzoni ◽  
Andrea Vitali ◽  
Caterina Rizzi
Keyword(s):  
Motion Tracking ◽  
Daily Life ◽  
Low Cost ◽  
Research Work ◽  
Medical Personnel ◽  
Ease Of Use ◽  
Hand Tracking ◽  
Rehabilitation Programs ◽  
Patient Side ◽  
At Home

Abstract In the last years, the advent of innovative technologies for tracking human motions is increasing the interest of physicians and physiotherapist, who would like to introduce new instruments for a more objective assessment of the rehabilitation processes. At present, many motion tracking systems have been developed and their ease of use and low-cost may represent the key aspects for which these systems could be really adopted both in rehabilitation centers and in rehabilitation programs at home. Several research studies confirmed the importance of continuing rehabilitation programs at home with the aim to maintain patients’ health condition at a suitable level for daily life activities. Physicians and physiotherapists need methods and tools, which can be simply adaptable for each type of patients’ category and type of rehabilitation according to the assessed pathology. For achieving this need, the technology has to be suitable for both the patient side and medical personnel side. The most suitable technology for the patients are motion tracking devices which can be used through traditional IT, such as laptops, smartphones and tablets. Also for medical personnel the ease of use is very important, physicians would like to check the patient’s rehab exercises according to their medical knowledge by exploiting daily life technology. This research work investigates on which are the best user-friendly programming tools and low-cost technology for 3D hand and finger tracking for the development of a serious game for rehabilitation exercises. The tasks are designed according to physiotherapists’ recommendations, in order to be customizable for any single user. The following sections will describe the method, the tools adopted, and the application developed.

scholarly journals Exhalation Delivery System (EDS) Intranasal Steroid vs Conventional Inhaled Nasal Steroids (INS): Patient Preference, Comfort and Ease of Use

2019 ◽  
Vol 143 (2) ◽  
pp. AB63
Author(s):  
Dareen D. Siri ◽  
John C. Messina ◽  
Jennifer L. Carothers ◽  
Harry J. Sacks ◽  
Ramy A. Mahmoud
Keyword(s):  
Delivery System ◽  
Patient Preference ◽  
Ease Of Use ◽  
Nasal Steroids

scholarly journals NanoGalaxy: Nanopore long-read sequencing data analysis in Galaxy

GigaScience ◽  
2020 ◽  
Vol 9 (10) ◽  
Author(s):  
Willem de Koning ◽  
Milad Miladi ◽  
Saskia Hiltemann ◽  
Astrid Heikema ◽  
John P Hays ◽  
...  
Keyword(s):  
Genome Assembly ◽  
Bioinformatics Analysis ◽  
De Novo ◽  
Sequence Data ◽  
Ease Of Use ◽  
Easy Access ◽  
Complex Data ◽  
Sequencing Data ◽  
Long Read ◽  
Sequencing Platforms

Abstract Background Long-read sequencing can be applied to generate very long contigs and even completely assembled genomes at relatively low cost and with minimal sample preparation. As a result, long-read sequencing platforms are becoming more popular. In this respect, the Oxford Nanopore Technologies–based long-read sequencing “nanopore" platform is becoming a widely used tool with a broad range of applications and end-users. However, the need to explore and manipulate the complex data generated by long-read sequencing platforms necessitates accompanying specialized bioinformatics platforms and tools to process the long-read data correctly. Importantly, such tools should additionally help democratize bioinformatics analysis by enabling easy access and ease-of-use solutions for researchers. Results The Galaxy platform provides a user-friendly interface to computational command line–based tools, handles the software dependencies, and provides refined workflows. The users do not have to possess programming experience or extended computer skills. The interface enables researchers to perform powerful bioinformatics analysis, including the assembly and analysis of short- or long-read sequence data. The newly developed “NanoGalaxy" is a Galaxy-based toolkit for analysing long-read sequencing data, which is suitable for diverse applications, including de novo genome assembly from genomic, metagenomic, and plasmid sequence reads. Conclusions A range of best-practice tools and workflows for long-read sequence genome assembly has been integrated into a NanoGalaxy platform to facilitate easy access and use of bioinformatics tools for researchers. NanoGalaxy is freely available at the European Galaxy server https://nanopore.usegalaxy.eu with supporting self-learning training material available at https://training.galaxyproject.org.

The Role of the Military in International Military-Civilian Collaboration for Disaster Medicine in the USA

1985 ◽  
Vol 1 (1) ◽  
pp. 21-22 ◽  
Author(s):  
Jay C. Bisgard
Keyword(s):  
Armed Forces ◽  
Medical Personnel ◽  
The United States ◽  
Disaster Medicine ◽  
Military Health ◽  
Life Saving ◽  
Ready Availability ◽  
The Usa ◽  
Rapid Deployment ◽  
The Military

The United States Military Health Care System exists primarily to ensure the ready availability of medical support to U.S. Armed Forces at any level of conflict anywhere in the world. Many military medical units are therefore organized and equipped to permit their rapid deployment on short warning to relatively remote areas. They can provide life-saving services within hours and can operate almost independently in any climate, provided they have the means to evacuate patients and to receive supplies. The military mission demands that the medical personnel assigned to these units be trained in peacetime to do their jobs in wartime.

A Practice-based Evaluation of a Novel Resin Luting Material and Dentine Bonding Agent

Dental Update ◽  
2021 ◽  
Vol 48 (1) ◽  
pp. 34-40
Author(s):  
Peter Sands ◽  
Russell J Crisp ◽  
Owen Thompson ◽  
FJ Trevor Burke
Keyword(s):  
Delivery System ◽  
Research Group ◽  
Clinical Relevance ◽  
Ease Of Use ◽  
Bonding Agent ◽  
The Novel ◽  
Practice Based Research ◽  
Luting Material ◽  
Clinical Cases

This study evaluated the handling of a recently introduced resin luting material and its associated universal bonding agent by a group of practice-based researchers. Eleven evaluators from the practice-based research group, the PREP Panel, were sent explanatory letters and a pack of the materials under investigation, with a request to use them, where indicated, for 10 weeks and then to complete a questionnaire designed to elicit the evaluators' views on the handling of the materials. In total, 217 restorations were placed: the results from the questionnaire indicated strong acceptance of the ease of use of the materials. The novel cement delivery system was found to reduce waste, the cement was of ideal viscosity, and the design of the mixing tips and easier clean up were particularly noteworthy. The investigators also appreciated that the same cement can cover adhesive and self-adhesive indications. Some clinical cases of different indications were documented and selected illustrations are presented. CPD/Clinical Relevance: The luting system which was evaluated was found to be easy to use, with reduced waste of material.

scholarly journals European real-world data about the use of a new delivery system containing a preservative-free multi-dose glaucoma treatment

2020 ◽  
pp. 112067212091934 ◽  
Author(s):  
Philippe Denis ◽  
Susana Duch ◽  
Enping Chen ◽  
Per Klyve ◽  
Jesper Skov ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Delivery System ◽  
Ease Of Use ◽  
Eye Drops ◽  
Dose Delivery ◽  
Real World Data ◽  
Number Of Patients ◽  
Glaucoma Treatment ◽  
Preservative Free ◽  
Better Than

Background Glaucoma treatments are mostly presented in uni-dose or multi-dose format. A certain number of patients with visual acuity and dexterity problems may have problems in instilling eye drops. Aim To assess patient satisfaction and ease of use of a preservative-free glaucoma treatment (dorzolamide/timolol) in a new and innovative patented multi-dose delivery system. Methods Retrospective, international, multicentre, non-interventional study in 788 adult patients using a multi-dose delivery system for at least 28 days. Results Mean patient age was 68.1 ± 12.1 years. Mean duration of multi-dose delivery system use was 132.1 ± 125.1 days; 66.5% of the patients previously used multi-dose and 33.5% uni-dose delivery systems (n = 734); 78.3% of the patients were satisfied or very satisfied with the multi-dose delivery system. A significant majority (all p ≤ 0.045) of patients with a QuickDash® score between [0 to 25[ (66.4%, n = 211) and [50 to 75[ (81.8%, n = 11) rated multi-dose delivery system as easy or very easy to open and significantly more subjects in the [0 to 25[ (72%) score group rated multi-dose delivery system as being better or much better than their previous device (n = 211). Significantly (all p < 0.01) more subjects with available visual acuity results rated multi-dose delivery system as good, better or much better than their previous dispensing device. Conclusion The tested multi-dose delivery system was highly accepted. It is, therefore, suitable for glaucoma patients with decreased visual acuity and/or dexterity problems. Further studies may be necessary to assess the easiness of use of this easy-to-grip delivery system.

scholarly journals A New Mouse Model of Diffuse Midline Glioma to Test Targeted Immunotherapies

2021 ◽  
Author(s):  
Maggie D Seblani ◽  
Markella Zannikou ◽  
Joseph Duffy ◽  
Rebecca N Levine ◽  
Qianli Liu ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Cell Lines ◽  
Median Survival ◽  
Delivery System ◽  
De Novo ◽  
High Grade Glioma ◽  
Cre Recombinase ◽  
High Grade ◽  
Diffuse Midline Glioma ◽  
De Novo Tumors

BACKGROUND: Diffuse midline gliomas remain incurable, with consistently poor outcomes in children despite radiotherapy. Immunotherapeutic approaches hold promise, with the integration of the host's immune system fundamental to their design. Here, we describe a new, genetically engineered immunocompetent model that incorporates interleukin 13 receptor alpha 2 (IL13Rα2), a tumor-associated antigen, which is suitable for further evaluation of the antitumor activity of IL13Rα2-targeted immunotherapeutics in preclinical studies. METHODS: The RCAS-Tv-a delivery system was used to induce gliomagenesis through overexpression of PDGFB and p53 deletion with and without human IL13Rα2 in Nestin-Tva; p53fl/fl mice. Neonatal pups were infected with Cre recombinase and PDGFB+IL13Rα2 or Cre recombinase and PDGFB in forth ventricle or right cortex of the brain to model diffuse midline glioma and pediatric high-grade glioma, respectively. Immunoblotting and flow cytometry was used to confirm target expression. Kaplan-Meier survival curves were established to compare tumor latency in both models. Tumor tissue was analyzed through immunohistochemistry and H&E staining. Cell lines generated from tumor-bearing mice were used for in vitro studies and orthotopic injections. RESULTS: The protein expression of PDGFB and IL13Rα2 was confirmed by flow cytometry and western blot. In both groups, de novo tumors developed without significant difference in median survival between PDGFB and p53 loss (n=25, 40 days) and PDGB, IL13Rα2, and p53 loss (n=33, 38 days, p=0.62). Tumors demonstrated characteristics of high-grade glioma such as infiltration, palisading necrosis, microvascular proliferation, high Ki-67 index, heterogeneous IL13Rα2 expression, and CD11b+ macrophages, along with a low proportion of CD3+ T cells. Orthotopic tumors developed from cell lines retained histopathological characteristics of de novo tumors. Mice orthotopically implanted with cells in the 4th ventricle or right cortex showed a median survival of 42 days and 41 (p=0.56) days, respectively. CONCLUSION: Generation of de novo tumors using the RCAS-Tv-a delivery system was successful, with tumors possessing histopathologic features common to pediatric diffuse gliomas. The development of these models opens the opportunity for preclinical assessment of IL13Rα2-directed immunotherapies with the potential for clinical translation.

scholarly journals Escalation to Barbiturate-Induced Coma for Refractory Seizures after Liver Transplantation

2022 ◽  
Vol 2022 ◽  
pp. 1-4
Author(s):  
Brittany Miles ◽  
Muhammad Mujtaba ◽  
Shehzad Merwat ◽  
Rupak Kulkarni ◽  
Jeffrey Fair ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Antiepileptic Drugs ◽  
Conventional Treatment ◽  
De Novo ◽  
Seizure Activity ◽  
Burst Suppression ◽  
Full Recovery ◽  
Ventilator Support ◽  
Generalized Seizures ◽  
Refractory Seizures

Seizures after liver transplantation were previously thought to be a reliable harbinger of catastrophe, but more recent studies have found seizure activity to be relatively common, and most cases do not result in a poor outcome. Generalized seizures are the most common, and they typically occur de novo within the first two weeks after transplantation. The underlying cause for seizure activity in these patients may be complex, with potential etiologies including metabolic, infectious, cerebrovascular, and medication-induced causes. Identification of the underlying cause and the use of antiepileptic drugs (AEDs) is crucial for minimizing risk to the patient’s neurologic and overall health. In this report, we present the case of a patient with refractory seizures unresponsive to conventional treatment, requiring prolonged barbiturate burst suppression with ventilator support. Seizure activity eventually ceased, and the patient made a full recovery.

De novo design of Self-assembly Hydrogels based on Fmoc-diphenylalanine Providing with Drug Release

2021 ◽  
Author(s):  
Xiang Li ◽  
Huijun Zhang ◽  
Lingyan Liu ◽  
Chunyan Cao ◽  
Peng Wei ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Self Assembly ◽  
De Novo ◽  
De Novo Design ◽  
Short Peptides ◽  
Self Assembled

The short peptides with self-assembled nanostructures are widely applied in the areas of drug delivery system and biomaterials. In this article, we create a new peptide-based hydrogelator (Fmoc-FFRRVR) based on...

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