scholarly journals Correction: Metagenomics analysis reveals features unique to Indian distal gut microbiota

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243397
Author(s):  
2017 ◽  
Vol 35 (2) ◽  
pp. 101
Author(s):  
Auncha Thatrimontrichai

The collaboration and symbiotic relationship between microbiota and humans is complex. Development of the gut microbiota in infants is a dynamic process that is dependent on maternal-fetal-neonatal determinants. Vast collaborative enterprises of cooperative, co-dependent, and competitive ecologies are enormously powerful when merged together as one discrete entity or organ. This forgotten and invisible organ has both benefits and harm in health throughout the life cycle and across the next generations for the long term. Rapid advances in microbiology, genomic research and metagenomics analysis have uncovered the microbial contribution in both the hugeness and diversity of the microbial sphere. As a result, simultaneous findings have repercussions for microbial growth and health in the neonatal period and extend into childhood and adulthood. Pioneer microbiota in and on the neonate may find 'windows of opportunity' to promote health and prevent diseases. Oral probiotics is one choice to alter and balance the gut microbiota. However, the heterogeneity of research outcomes cannot be applied routinely in premature infants.


2022 ◽  
Vol 12 (1) ◽  
Author(s):  
Fengjun Li ◽  
Shengzhi Yang ◽  
Linwan Zhang ◽  
Lu Qiao ◽  
Lei Wang ◽  
...  

2017 ◽  
Vol 66 ◽  
pp. 173-184 ◽  
Author(s):  
R.M.C. Udayangani ◽  
S.H.S. Dananjaya ◽  
Chamilani Nikapitiya ◽  
Gang-Joon Heo ◽  
Jehee Lee ◽  
...  

PLoS ONE ◽  
2020 ◽  
Vol 15 (4) ◽  
pp. e0231197 ◽  
Author(s):  
Kamaldeep Kaur ◽  
Indu Khatri ◽  
Akil Akhtar ◽  
Srikrishna Subramanian ◽  
T. N. C. Ramya

Marine Drugs ◽  
2020 ◽  
Vol 18 (3) ◽  
pp. 175 ◽  
Author(s):  
H.P.S.U. Chandrarathna ◽  
T.D. Liyanage ◽  
S.L. Edirisinghe ◽  
S.H.S. Dananjaya ◽  
E.H.T. Thulshan ◽  
...  

This study evaluated the modulation of gut microbiota, immune responses, and gut morphometry in C57BL/6 mice, upon oral administration of S. maxima-derived modified pectin (SmP, 7.5 mg/mL) and pectin nanoparticles (SmPNPs; 7.5 mg/mL). Metagenomics analysis was conducted using fecal samples, and mice duodenum and jejunum were used for analyzing the immune response and gut morphometry, respectively. The results of metagenomics analysis revealed that the abundance of Bacteroidetes in the gut increased in response to both modified SmP and SmPNPs (75%) as compared with that in the control group (66%), while that of Firmicutes decreased in (20%) as compared with that in the control group (30%). The mRNA levels of mucin, antimicrobial peptide, and antiviral and gut permeability-related genes in the duodenum were significantly (p < 0.05) upregulated (> 2-fold) upon modified SmP and SmPNPs feeding. Protein level of intestinal alkaline phosphatase was increased (1.9-fold) in the duodenum of modified SmPNPs feeding, evidenced by significantly increased goblet cell density (0.5 ± 0.03 cells/1000 µm2) and villi height (352 ± 10 µm). Our results suggest that both modified SmP and SmPNPs have the potential to modulate gut microbial community, enhance the expression of immune related genes, and improve gut morphology.


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