scholarly journals A machine learning approach to predict pancreatic islet grafts rejection versus tolerance

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0241925
Author(s):  
Gerardo A. Ceballos ◽  
Luis F. Hernandez ◽  
Daniel Paredes ◽  
Luis R. Betancourt ◽  
Midhat H. Abdulreda
Keyword(s):  
Machine Learning ◽  
Pancreatic Islet ◽  
Support Vector ◽  
Medical Diagnoses ◽  
Laser Induced Fluorescence Detection ◽  
Classification Score ◽  
New Information ◽  
Islet Allografts ◽  
Machine Learning Approach ◽  
Positive Classification

The application of artificial intelligence (AI) and machine learning (ML) in biomedical research promises to unlock new information from the vast amounts of data being generated through the delivery of healthcare and the expanding high-throughput research applications. Such information can aid medical diagnoses and reveal various unique patterns of biochemical and immune features that can serve as early disease biomarkers. In this report, we demonstrate the feasibility of using an AI/ML approach in a relatively small dataset to discriminate among three categories of samples obtained from mice that either rejected or tolerated their pancreatic islet allografts following transplant in the anterior chamber of the eye, and from naïve controls. We created a locked software based on a support vector machine (SVM) technique for pattern recognition in electropherograms (EPGs) generated by micellar electrokinetic chromatography and laser induced fluorescence detection (MEKC-LIFD). Predictions were made based only on the aligned EPGs obtained in microliter-size aqueous humor samples representative of the immediate local microenvironment of the islet allografts. The analysis identified discriminative peaks in the EPGs of the three sample categories. Our classifier software was tested with targeted and untargeted peaks. Working with the patterns of untargeted peaks (i.e., based on the whole pattern of EPGs), it was able to achieve a 21 out of 22 positive classification score with a corresponding 95.45% prediction accuracy among the three sample categories, and 100% accuracy between the rejecting and tolerant recipients. These findings demonstrate the feasibility of AI/ML approaches to classify small numbers of samples and they warrant further studies to identify the analytes/biochemicals corresponding to discriminative features as potential biomarkers of islet allograft immune rejection and tolerance.

scholarly journals Distribution Grids Fault Location employing ST based Optimized Machine Learning Approach

Energies ◽  
2018 ◽  
Vol 11 (9) ◽  
pp. 2328 ◽  
Author(s):  
Md Shafiullah ◽  
M. Abido ◽  
Taher Abdel-Fattah
Keyword(s):  
Machine Learning ◽  
Fault Location ◽  
Percentage Error ◽  
Support Vector ◽  
Learning Approach ◽  
Efficiency Coefficient ◽  
Learning Tools ◽  
Performance Indices ◽  
Machine Learning Approach ◽  
Distribution Grids

Precise information of fault location plays a vital role in expediting the restoration process, after being subjected to any kind of fault in power distribution grids. This paper proposed the Stockwell transform (ST) based optimized machine learning approach, to locate the faults and to identify the faulty sections in the distribution grids. This research employed the ST to extract useful features from the recorded three-phase current signals and fetches them as inputs to different machine learning tools (MLT), including the multilayer perceptron neural networks (MLP-NN), support vector machines (SVM), and extreme learning machines (ELM). The proposed approach employed the constriction-factor particle swarm optimization (CF-PSO) technique, to optimize the parameters of the SVM and ELM for their better generalization performance. Hence, it compared the obtained results of the test datasets in terms of the selected statistical performance indices, including the root mean squared error (RMSE), mean absolute percentage error (MAPE), percent bias (PBIAS), RMSE-observations to standard deviation ratio (RSR), coefficient of determination (R2), Willmott’s index of agreement (WIA), and Nash–Sutcliffe model efficiency coefficient (NSEC) to confirm the effectiveness of the developed fault location scheme. The satisfactory values of the statistical performance indices, indicated the superiority of the optimized machine learning tools over the non-optimized tools in locating faults. In addition, this research confirmed the efficacy of the faulty section identification scheme based on overall accuracy. Furthermore, the presented results validated the robustness of the developed approach against the measurement noise and uncertainties associated with pre-fault loading condition, fault resistance, and inception angle.

scholarly journals Arabic English Cross-Lingual Plagiarism Detection Based on Keyphrases Extraction, Monolingual and Machine Learning Approach

2019 ◽  
pp. 1-12
Author(s):  
Mokhtar Al-Suhaiqi ◽  
Muneer A. S. Hazaa ◽  
Mohammed Albared
Keyword(s):  
Machine Learning ◽  
Machine Learning Techniques ◽  
Detection Methods ◽  
Support Vector ◽  
Svm Classifier ◽  
Learning Approach ◽  
Plagiarism Detection ◽  
Machine Learning Approach ◽  
Cross Lingual ◽  
Cross Language

Due to rapid growth of research articles in various languages, cross-lingual plagiarism detection problem has received increasing interest in recent years. Cross-lingual plagiarism detection is more challenging task than monolingual plagiarism detection. This paper addresses the problem of cross-lingual plagiarism detection (CLPD) by proposing a method that combines keyphrases extraction, monolingual detection methods and machine learning approach. The research methodology used in this study has facilitated to accomplish the objectives in terms of designing, developing, and implementing an efficient Arabic – English cross lingual plagiarism detection. This paper empirically evaluates five different monolingual plagiarism detection methods namely i)N-Grams Similarity, ii)Longest Common Subsequence, iii)Dice Coefficient, iv)Fingerprint based Jaccard Similarity  and v) Fingerprint based Containment Similarity. In addition, three machine learning approaches namely i) naïve Bayes, ii) Support Vector Machine, and iii) linear logistic regression classifiers are used for Arabic-English Cross-language plagiarism detection. Several experiments are conducted to evaluate the performance of the key phrases extraction methods. In addition, Several experiments to investigate the performance of machine learning techniques to find the best method for Arabic-English Cross-language plagiarism detection. According to the experiments of Arabic-English Cross-language plagiarism detection, the highest result was obtained using SVM   classifier with 92% f-measure. In addition, the highest results were obtained by all classifiers are achieved, when most of the monolingual plagiarism detection methods are used. 

scholarly journals Driver Stress State Evaluation by Means of Thermal Imaging: A Supervised Machine Learning Approach Based on ECG Signal

2020 ◽  
Vol 10 (16) ◽  
pp. 5673 ◽  
Author(s):  
Daniela Cardone ◽  
David Perpetuini ◽  
Chiara Filippini ◽  
Edoardo Spadolini ◽  
Lorenza Mancini ◽  
...  
Keyword(s):  
Machine Learning ◽  
Stress State ◽  
Thermal Imaging ◽  
Driving Simulator ◽  
Supervised Machine Learning ◽  
Support Vector ◽  
Learning Approach ◽  
Machine Learning Approach ◽  
Thermal Features ◽  
Driver Stress

Traffic accidents determine a large number of injuries, sometimes fatal, every year. Among other factors affecting a driver’s performance, an important role is played by stress which can decrease decision-making capabilities and situational awareness. In this perspective, it would be beneficial to develop a non-invasive driver stress monitoring system able to recognize the driver’s altered state. In this study, a contactless procedure for drivers’ stress state assessment by means of thermal infrared imaging was investigated. Thermal imaging was acquired during an experiment on a driving simulator, and thermal features of stress were investigated with comparison to a gold-standard metric (i.e., the stress index, SI) extracted from contact electrocardiography (ECG). A data-driven multivariate machine learning approach based on a non-linear support vector regression (SVR) was employed to estimate the SI through thermal features extracted from facial regions of interest (i.e., nose tip, nostrils, glabella). The predicted SI showed a good correlation with the real SI (r = 0.61, p = ~0). A two-level classification of the stress state (STRESS, SI ≥ 150, versus NO STRESS, SI < 150) was then performed based on the predicted SI. The ROC analysis showed a good classification performance with an AUC of 0.80, a sensitivity of 77%, and a specificity of 78%.

scholarly journals Accelerometer-Based Fall Detection Using Machine Learning: Training and Testing on Real-World Falls

Sensors ◽  
2020 ◽  
Vol 20 (22) ◽  
pp. 6479
Author(s):  
Luca Palmerini ◽  
Jochen Klenk ◽  
Clemens Becker ◽  
Lorenzo Chiari
Keyword(s):  
Machine Learning ◽  
Real World ◽  
Inertial Sensor ◽  
Fall Detection ◽  
Medical Attention ◽  
Support Vector ◽  
Detection Algorithms ◽  
Detection Systems ◽  
Machine Learning Approach ◽  
Extensive Collection

Falling is a significant health problem. Fall detection, to alert for medical attention, has been gaining increasing attention. Still, most of the existing studies use falls simulated in a laboratory environment to test the obtained performance. We analyzed the acceleration signals recorded by an inertial sensor on the lower back during 143 real-world falls (the most extensive collection to date) from the FARSEEING repository. Such data were obtained from continuous real-world monitoring of subjects with a moderate-to-high risk of falling. We designed and tested fall detection algorithms using features inspired by a multiphase fall model and a machine learning approach. The obtained results suggest that algorithms can learn effectively from features extracted from a multiphase fall model, consistently overperforming more conventional features. The most promising method (support vector machines and features from the multiphase fall model) obtained a sensitivity higher than 80%, a false alarm rate per hour of 0.56, and an F-measure of 64.6%. The reported results and methodologies represent an advancement of knowledge on real-world fall detection and suggest useful metrics for characterizing fall detection systems for real-world use.

scholarly journals Validation of miRNAs as Breast Cancer Biomarkers with a Machine Learning Approach

Cancers ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 431 ◽  
Author(s):  
Oneeb Rehman ◽  
Hanqi Zhuang ◽  
Ali Muhamed Ali ◽  
Ali Ibrahim ◽  
Zhongwei Li
Keyword(s):  
Breast Cancer ◽  
Machine Learning ◽  
Information Gain ◽  
Support Vector ◽  
Learning Approach ◽  
Breast Cancers ◽  
Functional Studies ◽  
Normal Tissues ◽  
Machine Learning Approach ◽  
Chi Squared

Certain small noncoding microRNAs (miRNAs) are differentially expressed in normal tissues and cancers, which makes them great candidates for biomarkers for cancer. Previously, a selected subset of miRNAs has been experimentally verified to be linked to breast cancer. In this paper, we validated the importance of these miRNAs using a machine learning approach on miRNA expression data. We performed feature selection, using Information Gain (IG), Chi-Squared (CHI2) and Least Absolute Shrinkage and Selection Operation (LASSO), on the set of these relevant miRNAs to rank them by importance. We then performed cancer classification using these miRNAs as features using Random Forest (RF) and Support Vector Machine (SVM) classifiers. Our results demonstrated that the miRNAs ranked higher by our analysis had higher classifier performance. Performance becomes lower as the rank of the miRNA decreases, confirming that these miRNAs had different degrees of importance as biomarkers. Furthermore, we discovered that using a minimum of three miRNAs as biomarkers for breast cancers can be as effective as using the entire set of 1800 miRNAs. This work suggests that machine learning is a useful tool for functional studies of miRNAs for cancer detection and diagnosis.

scholarly journals Machine Learning Approach to Raman Spectrum Analysis of MIA PaCa-2 Pancreatic Cancer Tumor Repopulating Cells for Classification and Feature Analysis

Life ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 181
Author(s):  
Christopher T. Mandrell ◽  
Torrey E. Holland ◽  
James F. Wheeler ◽  
Sakineh M. A. Esmaeili ◽  
Kshitij Amar ◽  
...  
Keyword(s):  
Machine Learning ◽  
Pancreatic Cancer ◽  
Raman Spectra ◽  
Pancreatic Cancer Cell Line ◽  
Cancer Cell Line ◽  
Human Pancreatic Cancer ◽  
Support Vector ◽  
Learning Approach ◽  
K Nearest Neighbor ◽  
Machine Learning Approach

A machine learning approach is applied to Raman spectra of cells from the MIA PaCa-2 human pancreatic cancer cell line to distinguish between tumor repopulating cells (TRCs) and parental control cells, and to aid in the identification of molecular signatures. Fifty-one Raman spectra from the two types of cells are analyzed to determine the best combination of data type, dimension size, and classification technique to differentiate the cell types. An accuracy of 0.98 is obtained from support vector machine (SVM) and k-nearest neighbor (kNN) classifiers with various dimension reduction and feature selection tools. We also identify some possible biomolecules that cause the spectral peaks that led to the best results.

A Study of Cross-National Differences in Happiness Factors Using Machine Learning Approach

2015 ◽  
Vol 25 (09n10) ◽  
pp. 1699-1702 ◽  
Author(s):  
Theresia Ratih Dewi Saputri ◽  
Seok-Won Lee
Keyword(s):  
Machine Learning ◽  
Information Gain ◽  
Development Project ◽  
Support Vector ◽  
National Differences ◽  
Dimensionality Reduction Technique ◽  
Machine Learning Approach ◽  
National Happiness ◽  
Using Data ◽  
Cross National

National happiness has been actively studied throughout the past years. The happiness factor varies due to different human perspectives. The factors used in this work include both physical needs and the mental needs of humanity, for example, the educational factor. This work identified more than 90 features that can be used to predict the country happiness. Due to numerous features, it is unwise to rely on the prediction of national happiness by manual analysis. Therefore, this work used a machine learning technique called Support Vector Machine (SVM) to learn and predict the country happiness. In order to improve the prediction accuracy, dimensionality reduction technique which is the information gain was also used in this work. This technique was chosen due to its ability to explore the interrelationships among a set of variables. Using data of 187 countries from the UN Development Project, this work is able to identify which factor needed to be improved by a certain country to increase the happiness of their citizens.

scholarly journals A machine learning approach for planning valve-sparing aortic root reconstruction

2015 ◽  
Vol 1 (1) ◽  
pp. 361-365 ◽  
Author(s):  
J. Hagenah ◽  
M. Scharfschwerdt ◽  
A. Schlaefer ◽  
C. Metzner
Keyword(s):  
Machine Learning ◽  
Aortic Root ◽  
Biomechanical Properties ◽  
Support Vector ◽  
Ultrasound Images ◽  
Surgery Planning ◽  
Geometrical Features ◽  
Machine Learning Approach ◽  
First Results ◽  
Valve Sparing

AbstractChoosing the optimal prosthesis size and shape is a difficult task during surgical valve-sparing aortic root reconstruction. Hence, there is a need for surgery planning tools. Common surgery planning approaches try to model the mechanical behaviour of the aortic valve and its leaflets. However, these approaches suffer from inaccuracies due to unknown biomechanical properties and from a high computational complexity. In this paper, we present a new approach based on machine learning that avoids these problems. The valve geometry is described by geometrical features obtained from ultrasound images. We interpret the surgery planning as a learning problem, in which the features of the healthy valve are predicted from these of the dilated valve using support vector regression (SVR). Our first results indicate that a machine learning based surgery planning can be possible.

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