Neurobehavior of newborn infants exposed prenatally to methadone and identification of a neurobehavioral profile linked to poorer neurodevelopmental outcomes at age 24 months

Trecia A. Wouldes; Lianne J. Woodward

doi:10.1371/journal.pone.0240905

Predictive value of color doppler neuro-sonography for the development of neurological sequels in newborn infants with hypoxic ischemic encephalopathy

Vojnosanitetski pregled ◽

10.2298/vsp1110825v ◽

2011 ◽

Vol 68 (10) ◽

pp. 825-831

Author(s):

Brankica Vasiljevic ◽

Svjetlana Maglajlic-Djukic ◽

Sanja Stankovic ◽

Dragana Lutovac ◽

Miroslava Gojnic

Keyword(s):

Predictive Value ◽

Color Doppler ◽

Newborn Infants ◽

Neurodevelopmental Outcome ◽

Staging System ◽

Hypoxic Ischemic Encephalopathy ◽

Clinical Staging ◽

Neurodevelopmental Outcomes ◽

Significant Difference ◽

Ischemic Encephalopathy

Background/Aim. The use of color Doppler neurosonography (cD-US) allows simultaneous examination of parenchymal and vascular cerebral structures. Evaluation of cerebral blood flow velocities (CBFV) and vascular resistance are important in assessment of cerebral circulation in neonates with hypoxic ischemic encephalopathy (HIE). The aim of this study was to evaluate the predictive value of cD-US for abnormal neurodevelopmental outcome in the neonates with HIE. Methods. A total of 90 neonates (>32 weeks gestational age) with HIE were enrolled prospectively. All the neonates with HIE were categorized into three grades according to the Sarnat and Sarnat clinical staging system: mild HIE, moderate HIE, and severe HIE. cD-US was performed simultaneously during the first 24 h of life. Neurodevelopment outcome was assessed at 12 months of age in all the neonates. Resluts. The values of CBFV and the values of index resistance (RI) correlated with the severity of HIE (p < 0.0001) and subsequent neurodevelopmental outcome (p < 0.001). We detected a significant difference in values of CBFV and in values of RI between preterm and full-term neonates (p < 0.01). The cut-off value of RI for poor neurodevelopmental outcomes was 0.81. Conclusions. cD-US could be very useful and safe diagnostic tool for assessing severity of HIE and subsequent adverse neurodevelopmental outcome.

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Treating Seizures after Hypoxic-Ischemic Encephalopathy—Current Controversies and Future Directions

International Journal of Molecular Sciences ◽

10.3390/ijms22137121 ◽

2021 ◽

Vol 22 (13) ◽

pp. 7121

Author(s):

Kelly Q. Zhou ◽

Alice McDouall ◽

Paul P. Drury ◽

Christopher A. Lear ◽

Kenta H. T. Cho ◽

...

Keyword(s):

Therapeutic Hypothermia ◽

Newborn Infants ◽

Developing Brain ◽

Hypoxic Ischemic Encephalopathy ◽

Neurodevelopmental Outcomes ◽

High Quality ◽

Future Directions ◽

Phenobarbital Administration ◽

The Impact ◽

Ischemic Encephalopathy

Seizures are common in newborn infants with hypoxic-ischemic encephalopathy and are highly associated with adverse neurodevelopmental outcomes. The impact of seizure activity on the developing brain and the most effective way to manage these seizures remain surprisingly poorly understood, particularly in the era of therapeutic hypothermia. Critically, the extent to which seizures exacerbate brain injury or merely reflect the underlying evolution of injury is unclear. Current anticonvulsants, such as phenobarbital and phenytoin have poor efficacy and preclinical studies suggest that most anticonvulsants are associated with adverse effects on the developing brain. Levetiracetam seems to have less potential neurotoxic effects than other anticonvulsants but may not be more effective. Given that therapeutic hypothermia itself has significant anticonvulsant effects, randomized controlled trials of anticonvulsants combined with therapeutic hypothermia, are required to properly determine the safety and efficacy of these drugs. Small clinical studies suggest that prophylactic phenobarbital administration may improve neurodevelopmental outcomes compared to delayed administration; however, larger high-quality studies are required to confirm this. In conclusion, there is a distinct lack of high-quality evidence for whether and to what extent neonatal seizures exacerbate brain damage after hypoxia-ischemia and how best to manage them in the era of therapeutic hypothermia.

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Impact of emollient therapy for preterm infants in the neonatal period on child neurodevelopment in Bangladesh: an observational cohort study

Journal of Health Population and Nutrition ◽

10.1186/s41043-021-00248-9 ◽

2021 ◽

Vol 40 (1) ◽

Author(s):

Gary L. Darmstadt ◽

Naila Z. Khan ◽

Summer Rosenstock ◽

Humaira Muslima ◽

Monowara Parveen ◽

...

Keyword(s):

Preterm Infants ◽

Assessment Tool ◽

Neonatal Period ◽

Newborn Infants ◽

Psychomotor Development ◽

Fine Motor ◽

Neurodevelopmental Outcomes ◽

Link Type ◽

Child Neurodevelopment

Abstract Background Topical treatment with sunflower seed oil (SSO) or Aquaphor® reduced sepsis and neonatal mortality in hospitalized preterm infants <33 weeks’ gestational age in Bangladesh. We sought to determine whether the emollient treatments improved neurodevelopmental outcomes during early childhood. Methods 497 infants were randomized to receive SSO, Aquaphor®, or neither through the neonatal period or hospital discharge. 159 infant survivors were enrolled in the longitudinal follow-up study using a validated Rapid Neurodevelopmental Assessment tool and the Bayley Scales of Infant Development II (BSID II) administered at three-monthly intervals for the first year and thereafter at six-monthly intervals. Lowess smoothing was used to display neurodevelopmental status across multiple domains by age and treatment group, and Generalized Estimating Equations (GEE) were used to compare treatment groups across age points. Results 123 children completed at least one follow-up visit. Lowess graphs suggest that lower proportions of children who received massage with either SSO or Aquaphor® had neurodevelopmental delays than control infants in a composite outcome of disabilities. In GEE analysis, infants receiving SSO showed a significant protective effect on the development of fine motor skills [odds ratio (OR) 0.92, 95% confidence interval (CI) 0.86–0.98, p=0.006]. The Psychomotor Development Index (PDI) in the BSID II showed significantly lower disability rates in the Aquaphor group (23.6%) compared to the control (55.2%) (OR 0.21, 95% CI 0.06–0.72, p=0.004). Conclusions Emollient massage of very preterm, hospitalized newborn infants improved some child neurodevelopmental outcomes over the first 2 years of follow-up. Findings warrant further confirmatory research. Trial registration ClinicalTrials.gov (98-04-21-03-2) under weblink https://clinicaltrials.gov/ct2/show/NCT00162747

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Neurobehavioral profile of healthy full-term newborn infants of adolescent mothers

Early Human Development ◽

10.1016/j.earlhumdev.2007.07.001 ◽

2008 ◽

Vol 84 (5) ◽

pp. 281-287 ◽

Cited By ~ 13

Author(s):

Marina Carvalho de Moraes Barros ◽

Ruth Guinsburg ◽

Sandro Mitsuhiro ◽

Elisa Chalem ◽

Ronaldo Ramos Laranjeira

Keyword(s):

Adolescent Mothers ◽

Newborn Infants ◽

Full Term ◽

Term Newborn ◽

Neurobehavioral Profile

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Effect of neonatal resuscitation courses on long-term neurodevelopmental outcomes of newborn infants with perinatal asphyxia

Pediatrics International ◽

10.1111/j.1442-200x.2011.03463.x ◽

2011 ◽

Vol 54 (1) ◽

pp. 56-59 ◽

Cited By ~ 5

Author(s):

Rıdvan Duran ◽

Işık Görker ◽

Yasemin Küçükuğurluoğlu ◽

Nükhet AladağÇiftdemir ◽

Ülfet Vatansever Özbek ◽

...

Keyword(s):

Perinatal Asphyxia ◽

Newborn Infants ◽

Neonatal Resuscitation ◽

Neurodevelopmental Outcomes

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Outcome of vein of Galen malformation presenting in the neonatal period

Archives of Disease in Childhood ◽

10.1136/archdischild-2018-316495 ◽

2019 ◽

Vol 104 (11) ◽

pp. 1064-1069 ◽

Cited By ~ 2

Author(s):

Stephanie Malarbi ◽

Julia K Gunn-Charlton ◽

Alice C Burnett ◽

Trisha M Prentice ◽

Amy Williams ◽

...

Keyword(s):

Middle Childhood ◽

Neonatal Intensive Care ◽

Neonatal Period ◽

Newborn Infants ◽

Neurodevelopmental Outcome ◽

Neurodevelopmental Outcomes ◽

Eligibility Criteria ◽

Neuroimaging Data ◽

Nicu Admission

ObjectiveVein of Galenaneurysmal malformation (VGAM) is a rare but important congenital malformation presenting to neonatal intensive care units (NICUs), and with a change from surgical to endovascular management, survival for this condition has improved. However, there is little reported about the medical management decisions of infants with this condition and the associated long-term neurodevelopmental outcomes. We aim to report a single centre experience of both acute treatment and long-term outcomes of VGAM for those infants admitted to our NICU soon after birth.DesignRetrospective cohort study over a 15-year period from 2001 to 2015 inclusive.SettingA quaternary NICU at The Royal Children’s Hospital, Melbourne, Australia.Participants24 newborn infants referred for management of VGAM. There were no eligibility criteria set for this study; all presenting infants were included.InterventionsNone.Main outcomes measuresClinical neuroimaging data were gathered. Surviving children were formally assessed with a battery of tests administered by a neuropsychologist and occupational therapist/physiotherapist at various ages across early to middle childhood.ResultsFifteen neonates with VGAM did not survive beyond their NICU admission. 10 of these were not offered endovascular intervention. Of the nine surviving infants, only one had a normal neurodevelopmental outcome.ConclusionsThe mortality of VGAM presenting in the neonatal period was high, and rates of normal neurodevelopmental outcome for survivors were low. These findings contribute to our understanding of which neonates should be treated and highlights the importance of providing clinical neurodevelopmental follow-up to survivors beyond their infant years.

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Potential benefits and pitfalls of skin-to-skin contact transport from birth room to neonatal unit

10.21203/rs.3.rs-324905/v1 ◽

2021 ◽

Author(s):

Nolwenn Clénet ◽

Laure Carneiro ◽

Carole Jeanneaud ◽

Geraldine Favrais

Keyword(s):

Gestational Age ◽

Newborn Infants ◽

Time Lapse ◽

Neonatal Unit ◽

Maternal Bonding ◽

Axillary Temperature ◽

Neurodevelopmental Outcomes ◽

Positive Effects ◽

Skin Contact ◽

Skin To Skin

Abstract Background: Early and repeated skin-to-skin contact (SSC) between infants and their parents during neonatal hospitalization has positive effects on maternal bonding, breastfeeding, parent-child interactions and preterm infant neurodevelopmental outcomes.Purpose: Transfers through SSC of newborn infants requiring intensive care over 300 meters between the birth room and neonatal unit have been implemented since 2018. The safety of SSC transfer with the infant’s father was questioned when compared to the more common transfer method in incubators.Methods: Singletons born from May to December 2019 at our three-level maternity ward that required intensive neonatal care were eligible. The infants’ axillary temperature, heart rate, and oxygen need were reported at four timepoints during transfer in an incubator or through SSC and at 30 minutes after arrival in the neonatal unit. Infant characteristics, blood gas, glycemia, time-lapse between birth and first SSC in the unit and feeding modes were also reported.Results: Median gestational age was higher in the SSC group (incubator (n=54): 32 weeks vs SSC (n=57): 36 weeks, p=.003). All infants requiring mechanical ventilation were transported in an incubator. A decrease in temperature was observed during incubator installation in the SSC group (incubator: 0°C vs SSC: -0.2°C, p< .001), but the first SSC in the unit was earlier in this group (incubator: 22 h vs SSC: 11 h, p= .001 and p= .008 after adjustment for gestational age). Implications for practice: Although thermal stability was compromised, encouraging results regarding the first SSC in the unit promote the continuation of SSC transfers.

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Characteristics of the Frequency-Following Response to Speech in Neonates and Potential Applicability in Clinical Practice: A Systematic Review

Journal of Speech Language and Hearing Research ◽

10.1044/2020_jslhr-19-00322 ◽

2020 ◽

Vol 63 (5) ◽

pp. 1618-1635

Author(s):

Céline Richard ◽

Mary Lauren Neel ◽

Arnaud Jeanvoine ◽

Sharon Mc Connell ◽

Alison Gehred ◽

...

Keyword(s):

Systematic Review ◽

Cochrane Library ◽

Neurodevelopmental Outcomes ◽

Frequency Following Response ◽

Ovid Medline ◽

Published Evidence ◽

Mesh Terms ◽

Potential Applicability ◽

Clinical Potential

Purpose We sought to critically analyze and evaluate published evidence regarding feasibility and clinical potential for predicting neurodevelopmental outcomes of the frequency-following responses (FFRs) to speech recordings in neonates (birth to 28 days). Method A systematic search of MeSH terms in the Cumulative Index to Nursing and Allied HealthLiterature, Embase, Google Scholar, Ovid Medline (R) and E-Pub Ahead of Print, In-Process & Other Non-Indexed Citations and Daily, Web of Science, SCOPUS, COCHRANE Library, and ClinicalTrials.gov was performed. Manual review of all items identified in the search was performed by two independent reviewers. Articles were evaluated based on the level of methodological quality and evidence according to the RTI item bank. Results Seven articles met inclusion criteria. None of the included studies reported neurodevelopmental outcomes past 3 months of age. Quality of the evidence ranged from moderate to high. Protocol variations were frequent. Conclusions Based on this systematic review, the FFR to speech can capture both temporal and spectral acoustic features in neonates. It can accurately be recorded in a fast and easy manner at the infant's bedside. However, at this time, further studies are needed to identify and validate which FFR features could be incorporated as an addition to standard evaluation of infant sound processing evaluation in subcortico-cortical networks. This review identifies the need for further research focused on identifying specific features of the neonatal FFRs, those with predictive value for early childhood outcomes to help guide targeted early speech and hearing interventions.

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