scholarly journals Factors associated with increased levels of brain natriuretic peptide and cardiac troponin I during the peripartum period

PLoS ONE ◽  
2019 ◽  
Vol 14 (2) ◽  
pp. e0211982
Author(s):  
Yuki Kimura ◽  
Takao Kato ◽  
Hiromi Miyata ◽  
Issei Sasaki ◽  
Eri Minamino-Muta ◽  
...  
Keyword(s):  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Cardiac Troponin I ◽  
Factors Associated ◽  
Peripartum Period

scholarly journals Brain natriuretic peptide (BNP) and cardiac troponin I(cTnI) for prediction of the prognosis in cancer patients with sepsis

2021 ◽  
Author(s):  
Yong Yang ◽  
Hongzhi Wang ◽  
JiaHua Leng ◽  
Xiuyun Tian ◽  
Chunyi Hao
Keyword(s):  
Brain Natriuretic Peptide ◽  
Cancer Patients ◽  
Natriuretic Peptide ◽  
Fluid Balance ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Cardiac Troponin I ◽  
Survival Group ◽  
Significant Difference ◽  
Death Group

Abstract Background This study aimed to study the value of brain natriuretic peptide (BNP) and cardiac troponin I(cTnI) for predicting the prognosis in cancer patients with sepsis. Methods A cohort of 233 cancer patients with sepsis admitted to our ICU from January 2017 to October 2020 was included in this retrospective study. BNP and cTnI on the first day (d1) and the third day(d3) after entering ICU, blood lactate (Lac), procalcitonin (PCT), Leucocyte, Sequential Organ failure assessment (SOFA) scores, the incidence of septic shock, acute kidney injury(AKI), acute respiratory failure (ARF) requiring mechanical ventilation(MV) and sepsis-induced myocardial dysfunction(SIMD) within 24 hours of entering ICU, fluid balance in 24hr and 72hr of entering ICU, time of MV, length of stay in ICU ,emergency surgery were collected. According to the 28-day mortality, these patients were divided into the survival group (190 cases) and the death group (43 cases). All the above variables were compared. Results The multiple COX regression analysis of these variables indicated that BNP on d1 and d3, SOFA scores ,72hr fluid balance were independent predictors of the mortality in these patients (P < 0.05); The area under the ROC curve was 0.91 ± 0.01(P < 0.05) for BNP on d3. BNP on d3 at 681.5 pg/mL predicted the mortality with a sensitivity of 91.5% and a specificity of 88.7%. All patients were divided into two groups (BNP on d3 < 681.5 pg/ml or > 681.5 pg/ml), Kaplan-Meier analysis performed on the two groups showed a significant difference in the survival curve (P < 0.05) .There were also significant differences on the comorbidities including shock, AKI, ARF in both groups (P < 0.05). 126 out of 233 patients underwent random bedside echocardiography, and a total of 42 cases developed SIMD with an incidence rate of 33.3% (30.6% in the survival group and 40.9% in the death group). There was no significant difference in the incidence of SIMD between the survival group and the death group (P = 0.23). There was a significant difference between the non-SIMD and the SIMD group for BNP on d1 and d3(P < 0.05). Conclusions BNP was a great predictor for the prognosis of cancer patients with sepsis, while cTnI was not.

scholarly journals The role of biochemical markers as early indicators of cardiac damage and prognostic parameters of perinatal asphyxia

2014 ◽  
Vol 71 (2) ◽  
pp. 149-155 ◽  
Author(s):  
Aleksandra Simovic ◽  
Jovan Kosutic ◽  
Sergej Prijic ◽  
Jasmina Knezevic ◽  
Ana Vujic ◽  
...  
Keyword(s):  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Perinatal Asphyxia ◽  
Cardiac Troponin I ◽  
Full Term ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Term Newborns

Background/Aim. In recent years, the focus of interest of the scientific community is the application of heart markers as early indicators and prognostic parameters of perinatal asphyxia (PA). The aim of this study was to evaluate the significance of clinical application of heart markers in term newborns with perinatal asphyxia. Methods. During a 3- year period we analyzed 91 full-term newborns (55 with and 36 without perinatal asphyxia). In all the subjects within the first 24-48 h after birth, we simultaneously determined serum concentrations of cardiac troponin I, brain natriuretic peptide, MB fraction of creatine kinase (CK-MB) and Creactive protein. Results. In the group of full-term neonates with PA significantly higher levels of cardiac troponinI (p = 0.000), CK-MB fraction (p = 0.000), brain natriuretic peptide (p = 0.003) and C-reactive protein (p = 0.017) were found, compared to the group of healthy full-term newborns. In merged group (n = 91) cardiac troponin I level correlated with the fifth minute Apgar score (r = - 0.637, p = 0.000) and the serum lactate concentration in the first 12h after birth (r = 0.529, p = 0.000). Early increase in cardiac troponin I > 0.135 ?g/L predicted the risk of death with the sensitivity of 84.6% and specificity of 85.9%, while the increase in CK-MB fraction, brain natriuretic peptide and C-reactive protein did not have a predictive value with respect to a mortality outcome. Conclusion. Among the tested cardiac markers, cardiac troponin I is the most sensitive and the only reliable early predictor of mortality in fullterm neonates with perinatal asphyxia.

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