scholarly journals Receptor for advanced glycation end-products and World Trade Center particulate induced lung function loss: A case-cohort study and murine model of acute particulate exposure

PLoS ONE ◽  
2017 ◽  
Vol 12 (9) ◽  
pp. e0184331 ◽  
Author(s):  
Erin J. Caraher ◽  
Sophia Kwon ◽  
Syed H. Haider ◽  
George Crowley ◽  
Audrey Lee ◽  
...  
Keyword(s):  
Cohort Study ◽  
Lung Function ◽  
Advanced Glycation End Products ◽  
World Trade ◽  
World Trade Center ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
Function Loss ◽  
End Products ◽  
Trade Center

scholarly journals Association between skin autofluorescence of advanced glycation end products and affective disorders in the lifelines cohort study

2020 ◽  
Vol 275 ◽  
pp. 230-237 ◽  
Author(s):  
Julia M. Hagen ◽  
Arjen L. Sutterland ◽  
Paulo A.L. da Fonseca Pereira de Sousa ◽  
Frederike Schirmbeck ◽  
Danny M. Cohn ◽  
...  
Keyword(s):  
Cohort Study ◽  
Advanced Glycation End Products ◽  
Affective Disorders ◽  
Skin Autofluorescence ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products

scholarly journals Measures of lung function and their relationship with advanced glycation end-products

2020 ◽  
Vol 6 (2) ◽  
pp. 00356-2019
Author(s):  
Suneela Zaigham ◽  
Margaretha Persson ◽  
Amra Jujic ◽  
Sophia Frantz ◽  
Yan Borné ◽  
...  
Keyword(s):  
Lung Function ◽  
Advanced Glycation End Products ◽  
Lung Parenchyma ◽  
Population Based ◽  
Forced Expiratory Volume ◽  
Chronic Obstructive ◽  
Advanced Glycation ◽  
Obstructive Pulmonary Disease ◽  
Glycation End Products ◽  
End Products

BackgroundAdvanced glycation end-products (AGEs) have been implicated in the pathophysiology of chronic obstructive pulmonary disease (COPD). However, the association between AGE accumulation in the skin measured by skin autofluorescence (SAF) and lung function in healthy subjects has not been explored in detail. We use a population-based study of 50–64-year-olds to assess spirometry, diffusing capacity of the lung for carbon monoxide (DLCO) and impulse oscillometry (IOS) in relation to SAF.MethodsParticipants with information on SAF, lung function and potential confounding variables were included from the Swedish Cardiopulmonary Bioimage Study (SCAPIS) cohort (spirometry, n=4111; DLCO, n=3889; IOS, n=3970). Linear regression was used to assess changes in lung function (as measured by spirometry (forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC), DLCO and IOS (resistance measured at 5 (R5) and 20 Hz (R20), R5−R20, area of reactance, reactance measured at 5 Hz (X­5), and resonant frequency)) by a 1-sd increase in SAF.ResultsFEV1, FVC and DLCO were significantly and inversely associated with SAF after adjustment for potential confounding factors (per 1-sd increase in SAF: FEV1 −0.03 L (95% CI −0.04– −0.02 L), p<0.001; FVC −0.03 L (95% CI −0.05– −0.02 L), p<0.001; DLCO −0.07 mmol·min−1·kPa−1 (95% CI −0.11– −0.03 mmol·min−1·kPa−1), p<0.001). This association was also found in nonsmokers and in non-COPD subjects. Pulmonary reactance (X5) but not pulmonary resistance (R5, R20 and R5−R20) was significantly associated with SAF (per 1-sd increase in SAF: X5 −0.001 kPa·L−1·s (95% CI −0.003–0.00 kPa·L−1·s), p=0.042), which was mirrored in non-COPD patients but not in current nonsmokers.ConclusionsAGE accumulation, as measured by SAF, is significantly associated with lung function decrements indicative of changes in the lung parenchyma

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