scholarly journals Genome-Wide Ultrabithorax Binding Analysis Reveals Highly Targeted Genomic Loci at Developmental Regulators and a Potential Connection to Polycomb-Mediated Regulation

PLoS ONE ◽  
2016 ◽  
Vol 11 (8) ◽  
pp. e0161997 ◽  
Author(s):  
Daria Shlyueva ◽  
Antonio C. A. Meireles-Filho ◽  
Michaela Pagani ◽  
Alexander Stark
Keyword(s):  
Binding Analysis ◽  
Genome Wide

scholarly journals Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Silvia Pomella ◽  
Prethish Sreenivas ◽  
Berkley E. Gryder ◽  
Long Wang ◽  
David Milewski ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Myogenic Differentiation ◽  
Terminal Differentiation ◽  
Muscle Differentiation ◽  
Chromatin Binding ◽  
Pediatric Malignancy ◽  
Ras Pathway ◽  
Oncogenic Ras ◽  
Binding Analysis ◽  
Genome Wide

AbstractRhabdomyosarcoma (RMS) is an aggressive pediatric malignancy of the muscle, that includes Fusion Positive (FP)-RMS harboring PAX3/7-FOXO1 and Fusion Negative (FN)-RMS commonly with RAS pathway mutations. RMS express myogenic master transcription factors MYOD and MYOG yet are unable to terminally differentiate. Here, we report that SNAI2 is highly expressed in FN-RMS, is oncogenic, blocks myogenic differentiation, and promotes growth. MYOD activates SNAI2 transcription via super enhancers with striped 3D contact architecture. Genome wide chromatin binding analysis demonstrates that SNAI2 preferentially binds enhancer elements and competes with MYOD at a subset of myogenic enhancers required for terminal differentiation. SNAI2 also suppresses expression of a muscle differentiation program modulated by MYOG, MEF2, and CDKN1A. Further, RAS/MEK-signaling modulates SNAI2 levels and binding to chromatin, suggesting that the differentiation blockade by oncogenic RAS is mediated in part by SNAI2. Thus, an interplay between SNAI2, MYOD, and RAS prevents myogenic differentiation and promotes tumorigenesis.

Genome-wide binding analysis of glucocorticoid receptors in the rat hippocampus in response to corticosterone and stress

2015 ◽  
Author(s):  
Benjamin P Flynn ◽  
John R Pooley ◽  
Yvonne M Kershaw ◽  
Songjoon Baek ◽  
Lars Grontved ◽  
...  
Keyword(s):  
Glucocorticoid Receptors ◽  
Rat Hippocampus ◽  
Binding Analysis ◽  
Genome Wide

scholarly journals Genome-wide binding analysis of the transcriptional regulator TrmBL1 in Pyrococcus furiosus

BMC Genomics ◽  
2016 ◽  
Vol 17 (1) ◽  
Author(s):  
Robert Reichelt ◽  
Antonia Gindner ◽  
Michael Thomm ◽  
Winfried Hausner
Keyword(s):  
Pyrococcus Furiosus ◽  
Transcriptional Regulator ◽  
Binding Analysis ◽  
Genome Wide

scholarly journals Genome‐wide binding analysis reveals that ANAC060 directly represses sugar‐induced transcription of ABI5 in Arabidopsis

2020 ◽  
Vol 103 (3) ◽  
pp. 965-979
Author(s):  
Bo Yu ◽  
Yuejun Wang ◽  
Hua Zhou ◽  
Ping Li ◽  
Chunmei Liu ◽  
...  
Keyword(s):  
Binding Analysis ◽  
Genome Wide

scholarly journals Identification of CodY Targets in Bacillus anthracis by Genome-Wide In Vitro Binding Analysis

2013 ◽  
Vol 195 (6) ◽  
pp. 1204-1213 ◽  
Author(s):  
A. Chateau ◽  
W. van Schaik ◽  
P. Joseph ◽  
L. D. Handke ◽  
S. M. McBride ◽  
...  
Keyword(s):  
Bacillus Anthracis ◽  
In Vitro Binding ◽  
Binding Analysis ◽  
Genome Wide ◽  
Vitro Binding

scholarly journals Genome-wide gene expression and promoter binding analysis identifies NFIL3 as a repressor of C/EBP target genes in neuronal outgrowth

2011 ◽  
Vol 46 (2) ◽  
pp. 460-468 ◽  
Author(s):  
Harold D. MacGillavry ◽  
Jochem Cornelis ◽  
Loek R. van der Kallen ◽  
Marion M. Sassen ◽  
Joost Verhaagen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Target Genes ◽  
Binding Analysis ◽  
Genome Wide ◽  
Neuronal Outgrowth ◽  
Genome Wide Gene Expression

scholarly journals Genome-wide binding analysis of AtGNC and AtCGA1 demonstrates their cross-regulation and common and specific functions

Plant Direct ◽  
2017 ◽  
Vol 1 (4) ◽  
pp. e00016 ◽  
Author(s):  
Zhenhua Xu ◽  
José A. Casaretto ◽  
Yong-Mei Bi ◽  
Steven J. Rothstein
Keyword(s):  
Binding Analysis ◽  
Genome Wide

scholarly journals Genome-wide RNA-binding analysis of the trypanosome U1 snRNP proteins U1C and U1-70K reveals cis/trans-spliceosomal network

2014 ◽  
Vol 42 (10) ◽  
pp. 6603-6615 ◽  
Author(s):  
Christian Preußer ◽  
Oliver Rossbach ◽  
Lee-Hsueh Hung ◽  
Dan Li ◽  
Albrecht Bindereif
Keyword(s):  
Rna Binding ◽  
Binding Analysis ◽  
Genome Wide ◽  
U1 Snrnp

scholarly journals Genome-Wide Binding Analysis of the Transcription Activator IDEAL PLANT ARCHITECTURE1 Reveals a Complex Network Regulating Rice Plant Architecture

2013 ◽  
Vol 25 (10) ◽  
pp. 3743-3759 ◽  
Author(s):  
Zefu Lu ◽  
Hong Yu ◽  
Guosheng Xiong ◽  
Jing Wang ◽  
Yongqing Jiao ◽  
...  
Keyword(s):  
Complex Network ◽  
Rice Plant ◽  
Plant Architecture ◽  
Transcription Activator ◽  
Binding Analysis ◽  
Genome Wide
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