scholarly journals Antiviral Role of IFITM Proteins in African Swine Fever Virus Infection

PLoS ONE ◽  
2016 ◽  
Vol 11 (4) ◽  
pp. e0154366 ◽  
Author(s):  
Raquel Muñoz-Moreno ◽  
Miguel Ángel Cuesta-Geijo ◽  
Carles Martínez-Romero ◽  
Lucía Barrado-Gil ◽  
Inmaculada Galindo ◽  
...  
Keyword(s):  
Virus Infection ◽  
African Swine Fever Virus ◽  
African Swine Fever ◽  
Fever Virus ◽  
Antiviral Role

GS-441524 inhibits African swine fever virus infection in vitro

2021 ◽  
pp. 105081
Author(s):  
Zhao Huang ◽  
Lang Gong ◽  
Zezhong Zheng ◽  
Qi Gao ◽  
Xiongnan Chen ◽  
...  
Keyword(s):  
Virus Infection ◽  
African Swine Fever Virus ◽  
African Swine Fever ◽  
Fever Virus

scholarly journals The Role of Interleukine-10 and Interferon-γ as Potential Markers of the Evolution of African Swine Fever Virus Infection in Wild Boar

Pathogens ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 757
Author(s):  
Sandra Barroso-Arévalo ◽  
Jose A. Barasona ◽  
Estefanía Cadenas-Fernández ◽  
José M. Sánchez-Vizcaíno
Keyword(s):  
Wild Boar ◽  
Vaccine Candidate ◽  
African Swine Fever Virus ◽  
African Swine Fever ◽  
Interferon Γ ◽  
Fever Virus ◽  
Control Group ◽  
Challenge Virus ◽  
Ifn Γ

African swine fever virus (ASFv) is one of the most challenging pathogens to affect both domestic and wild pigs. The disease has now spread to Europe and Asia, causing great damage to the pig industry. Although no commercial vaccine with which to control the disease is, as yet, available, some potential vaccine candidates have shown good results in terms of protection. However, little is known about the host immune mechanisms underlying that protection, especially in wild boar, which is the main reservoir of the disease in Europe. Here, we study the role played by two cytokines (IL-10 and IFN-γ) in wild boar orally inoculated with the attenuated vaccine candidate Lv17/WB/Rie1 and challenged with a virulent ASFv genotype II isolate. A group of naïve wild boar challenged with the latter isolate was also established as a control group. Our results showed that both cytokines play a key role in protecting the host against the challenge virus. While high levels of IL-10 in serum may trigger an immune system malfunctioning in challenged animals, the provision of stable levels of this cytokine over time may help to control the disease. This, together with high and timely induction of IFN-γ by the vaccine candidate, could help protect animals from fatal outcomes. Further studies should be conducted in order to support these preliminary results and confirm the role of these two cytokines as potential markers of the evolution of ASFV infection.

scholarly journals Phenotyping and susceptibility of established porcine cells lines to African Swine Fever Virus infection and viral production

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Elena G. Sánchez ◽  
Elena Riera ◽  
Marisa Nogal ◽  
Carmina Gallardo ◽  
Paloma Fernández ◽  
...  
Keyword(s):  
Virus Infection ◽  
African Swine Fever Virus ◽  
African Swine Fever ◽  
Fever Virus ◽  
Viral Production

scholarly journals Role of African swine fever virus (ASFV) proteins EP153R and EP402R in reducing viral persistence and virulence from attenuated BeninΔDP148R

2021 ◽  
Author(s):  
Vlad Petrovan ◽  
Anusyah Rathakrishnan ◽  
Muneeb Islam ◽  
Lynnette Goatley ◽  
Katy Moffat ◽  
...  
Keyword(s):  
Virus Replication ◽  
Vaccine Development ◽  
African Swine Fever Virus ◽  
Clinical Signs ◽  
African Swine Fever ◽  
Viral Persistence ◽  
Fever Virus ◽  
Post Immunization

The limited knowledge on the role of many of the approximately 170 proteins encoded by African swine fever virus restricts progress towards vaccine development. In this study we investigated the effect of deleting combinations of different genes from a previously attenuated virus, BeninΔDP148R on: virus replication in macrophages, virus persistence and clinical signs post immunization, and induction of protection against challenge. Deletion of either EP402R or EP153R genes individually or in combination from BeninΔDP148R did not reduce virus replication in vitro. However, deletion of EP402R dramatically reduced viral persistence in vivo, whilst maintaining high levels of protection against challenge. The additional deletion of EP153R (BeninΔDP148RΔEP153RΔEP402R) further attenuated the virus and no viremia or clinical signs were observed post immunization. This was associated with decreased protection and detection of moderate levels of challenge virus in blood. Interestingly, the deletion of EP153R alone from BeninΔDP148R did not result in further virus attenuation and a slight increase in virus genome copies in blood was observed at different times post immunization when compared with BeninΔDP148R. These results show that EP402R and EP153R have a synergistic role in promoting viremia, however EP153R alone does not seem to have a major impact on virus levels in blood.

scholarly journals The C-type lectin homologue gene (EP153R) of African swine fever virus inhibits apoptosis both in virus infection and in heterologous expression

Virology ◽  
2004 ◽  
Vol 326 (1) ◽  
pp. 160-170 ◽  
Author(s):  
Carolina Hurtado ◽  
Aitor G Granja ◽  
Marı́a J Bustos ◽  
Marı́a L Nogal ◽  
Gonzalo González de Buitrago ◽  
...  
Keyword(s):  
Virus Infection ◽  
Heterologous Expression ◽  
African Swine Fever Virus ◽  
African Swine Fever ◽  
Fever Virus

scholarly journals Small Rho GTPases and Cholesterol Biosynthetic Pathway Intermediates in African Swine Fever Virus Infection

2011 ◽  
Vol 86 (3) ◽  
pp. 1758-1767 ◽  
Author(s):  
J. I. Quetglas ◽  
B. Hernaez ◽  
I. Galindo ◽  
R. Munoz-Moreno ◽  
M. A. Cuesta-Geijo ◽  
...  
Keyword(s):  
Virus Infection ◽  
Rho Gtpases ◽  
Biosynthetic Pathway ◽  
African Swine Fever Virus ◽  
African Swine Fever ◽  
Fever Virus ◽  
Small Rho Gtpases ◽  
Cholesterol Biosynthetic Pathway

scholarly journals Disruption of Nuclear Organization during the Initial Phase of African Swine Fever Virus Infection

2011 ◽  
Vol 85 (16) ◽  
pp. 8263-8269 ◽  
Author(s):  
M. Ballester ◽  
C. Rodriguez-Carino ◽  
M. Perez ◽  
C. Gallardo ◽  
J. M. Rodriguez ◽  
...  
Keyword(s):  
Virus Infection ◽  
Initial Phase ◽  
African Swine Fever Virus ◽  
Nuclear Organization ◽  
African Swine Fever ◽  
Fever Virus

scholarly journals Mechanism of Collapse of Endoplasmic Reticulum Cisternae During African Swine Fever Virus Infection

Traffic ◽  
2011 ◽  
Vol 13 (1) ◽  
pp. 30-42 ◽  
Author(s):  
Miriam Windsor ◽  
Philippa Hawes ◽  
Paul Monaghan ◽  
Erik Snapp ◽  
María L. Salas ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Virus Infection ◽  
African Swine Fever Virus ◽  
African Swine Fever ◽  
Fever Virus

scholarly journals Cholesterol affects African swine fever virus infection

1998 ◽  
Vol 1393 (1) ◽  
pp. 19-25 ◽  
Author(s):  
C. Bernardes ◽  
A. António ◽  
Maria C. Pedroso de Lima ◽  
M.L. Valdeira
Keyword(s):  
Virus Infection ◽  
African Swine Fever Virus ◽  
African Swine Fever ◽  
Fever Virus
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