scholarly journals High Intensity Exercise in Multiple Sclerosis: Effects on Muscle Contractile Characteristics and Exercise Capacity, a Randomised Controlled Trial

PLoS ONE ◽  
2015 ◽  
Vol 10 (9) ◽  
pp. e0133697 ◽  
Author(s):  
Inez Wens ◽  
Ulrik Dalgas ◽  
Frank Vandenabeele ◽  
Lotte Grevendonk ◽  
Kenneth Verboven ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Randomised Controlled Trial ◽  
Exercise Capacity ◽  
High Intensity ◽  
Controlled Trial ◽  
High Intensity Exercise ◽  
Randomised Controlled ◽  
Muscle Contractile ◽  
Contractile Characteristics

scholarly journals Effect of a multimodal high intensity exercise intervention in cancer patients undergoing chemotherapy: randomised controlled trial

BMJ ◽  
2009 ◽  
Vol 339 (oct13 1) ◽  
pp. b3410-b3410 ◽  
Author(s):  
L. Adamsen ◽  
M. Quist ◽  
C. Andersen ◽  
T. Moller ◽  
J. Herrstedt ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Cancer Patients ◽  
High Intensity ◽  
Exercise Intervention ◽  
Controlled Trial ◽  
High Intensity Exercise ◽  
Randomised Controlled

scholarly journals Study protocol: randomised controlled trial evaluating exercise therapy as a supplemental treatment strategy in early multiple sclerosis: the Early Multiple Sclerosis Exercise Study (EMSES)

BMJ Open ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. e043699
Author(s):  
Morten Riemenschneider ◽  
Lars G Hvid ◽  
Steffen Ringgaard ◽  
Mikkel K E Nygaard ◽  
Simon F Eskildsen ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Randomised Controlled Trial ◽  
Usual Care ◽  
Treatment Strategy ◽  
Controlled Trial ◽  
Treatment Strategies ◽  
Control Group ◽  
Disease Course ◽  
Disability Progression ◽  
Randomised Controlled

IntroductionIn the relapsing remitting type of multiple sclerosis (MS) reducing relapses and neurodegeneration is crucial in halting the long-term impact of the disease. Medical disease-modifying treatments have proven effective, especially when introduced early in the disease course. However, patients still experience disease activity and disability progression, and therefore, supplemental early treatment strategies are warranted. Exercise appear to be one of the most promising supplemental treatment strategies, but a somewhat overlooked ‘window of opportunity’ exist early in the disease course. The objective of this study is to investigate exercise as a supplementary treatment strategy early in the disease course of MS.Methods and analysisThe presented Early Multiple Sclerosis Exercise Study is a 48-week (plus 1-year follow-up) national multicentre single-blinded parallel group randomised controlled trial comparing two groups receiving usual care plus supervised high-intense exercise or plus health education (active control). Additionally, data will be compared with a population-based control group receiving usual care only obtained from the Danish MS Registry. The primary outcomes are annual relapse rate and MRI derived global brain atrophy. The secondary outcomes are disability progression, physical and cognitive function, MS-related symptoms, and exploratory MRI outcomes. All analyses will be performed as intention to treat.Ethics and disseminationThe study is approved by The Central Denmark Region Committees on Health Research Ethics (1-10-72-388-17) and registered at the Danish Data Protection Agency (2016-051-000001 (706)). All study findings will be published in scientific peer-reviewed journals and presented at relevant scientific conferences.Trial registration numberNCT03322761.

scholarly journals CELEB trial: Comparative Effectiveness of Lung volume reduction surgery for Emphysema and Bronchoscopic lung volume reduction with valve placement: a protocol for a randomised controlled trial

BMJ Open ◽  
2018 ◽  
Vol 8 (10) ◽  
pp. e021368 ◽  
Author(s):  
Sara Buttery ◽  
Samuel V Kemp ◽  
Pallav L Shah ◽  
David Waller ◽  
Simon Jordan ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Exercise Capacity ◽  
Lung Volume ◽  
Clinical Decision Making ◽  
Controlled Trial ◽  
Airflow Obstruction ◽  
Volume Reduction ◽  
Lung Volume Reduction Surgery ◽  
Lung Volume Reduction ◽  
Randomised Controlled

IntroductionAlthough lung volume reduction surgery and bronchoscopic lung volume reduction with endobronchial valves have both been shown to improve lung function, exercise capacity and quality of life in appropriately selected patients with emphysema, there are no direct comparison data between the two procedures to inform clinical decision-making.Methods and analysisWe describe the protocol of the CELEB study, a randomised controlled trial which will compare outcomes at 1 year between the two procedures, using a composite disease severity measure, the iBODE score, which includes body mass index, airflow obstruction, dyspnoeaand exercise capacity (incremental shuttle walk test).Ethics and disseminationEthical approval to conduct the study has been obtained from the Fulham Research Ethics Committee, London (16/LO/0286). The outcome of this trial will provide information to guide treatment choices in this population and will be presented at national and international meetings and published in peer-reviewed journals. We will also disseminate the main results to all participants in a letter.Trial registration numberISRCTN19684749; Pre-results.

Muscle contractile characteristics: relationship to high-intensity exercise

2010 ◽  
Vol 110 (2) ◽  
pp. 295-300 ◽  
Author(s):  
Martyn G. Morris ◽  
Helen Dawes ◽  
Ken Howells ◽  
Oona M. Scott ◽  
Mary Cramp ◽  
...  
Keyword(s):  
High Intensity ◽  
High Intensity Exercise ◽  
Muscle Contractile ◽  
Contractile Characteristics
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