scholarly journals A Novel Mouse Model of Soft-Tissue Infection Using Bioluminescence Imaging Allows Noninvasive, Real-Time Monitoring of Bacterial Growth

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e106367 ◽  
Author(s):  
Kenji Yoshioka ◽  
Ken Ishii ◽  
Tetsuya Kuramoto ◽  
Shigenori Nagai ◽  
Haruki Funao ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Mouse Model ◽  
Real Time ◽  
Bacterial Growth ◽  
Soft Tissue Infection ◽  
Bioluminescence Imaging ◽  
Tissue Infection ◽  
Real Time Monitoring

Development of Bioluminescent Cronobacter sakazakii ATCC 29544 in a Mouse Model

2015 ◽  
Vol 78 (5) ◽  
pp. 1007-1012 ◽  
Author(s):  
XIWEN WANG ◽  
ZHIPING LI ◽  
XIAOLIN DONG ◽  
HANG CHI ◽  
GUANNAN WANG ◽  
...  
Keyword(s):  
Mouse Model ◽  
Real Time ◽  
Bioluminescence Imaging ◽  
Cronobacter Sakazakii ◽  
Real Time Monitoring ◽  
Model Study ◽  
Novel Approach ◽  
Living Mouse ◽  
Animal Model Study ◽  
Life Threatening

Cronobacter sakazakii is an emerging pathogen that causes severe and life-threatening conditions including meningitis, bacteremia, and necrotizing enterocolitis. An animal model study for extrapolation of C. sakazakii infection can provide a better understanding of pathogenesis. However, methods for real-time monitoring of the course of C. sakazakii infection in living animals have been lacking. We developed a bioluminescent C. sakazakii strain (ATCC 29544) that can be used for real-time monitoring of C. sakazakii infection in BALB/c mice. C. sakazakii ATCC 29544 mainly colonized brain, liver, spleen, kidney, and gastrointestinal tract, as indicated by bioluminescence imaging. This work provides a novel approach for studying the progression of C. sakazakii infection and evaluating therapeutics in a living mouse model.

Group G Streptococcal Necrotizing Soft Tissue Infection

2016 ◽  
Vol 78 (6) ◽  
pp. 644-649
Author(s):  
Eriko MAEHARA ◽  
Gaku TSUJI ◽  
Yukihiro MIZOTE ◽  
Naohide TAKEUCHI ◽  
Masutaka FURUE
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Infection ◽  
Tissue Infection ◽  
Necrotizing Soft Tissue Infection
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