scholarly journals Increased Sensitivity to Inflammatory Pain Induced by Subcutaneous Formalin Injection in Serine Racemase Knock-Out Mice

PLoS ONE ◽  
2014 ◽  
Vol 9 (8) ◽  
pp. e105282 ◽  
Author(s):  
Ayako Tabata-Imai ◽  
Ran Inoue ◽  
Hisashi Mori
Keyword(s):  
Inflammatory Pain ◽  
Serine Racemase ◽  
Formalin Injection ◽  
Knock Out ◽  
Increased Sensitivity ◽  
Knock Out Mice

Decreased levels of free d-aspartic acid in the forebrain of serine racemase (Srr) knock-out mice

2013 ◽  
Vol 62 (6) ◽  
pp. 843-847 ◽  
Author(s):  
Mao Horio ◽  
Tamaki Ishima ◽  
Yuko Fujita ◽  
Ran Inoue ◽  
Hisashi Mori ◽  
...  
Keyword(s):  
Aspartic Acid ◽  
Serine Racemase ◽  
Knock Out ◽  
Knock Out Mice

Levels of d-serine in the brain and peripheral organs of serine racemase (Srr) knock-out mice

2011 ◽  
Vol 59 (6) ◽  
pp. 853-859 ◽  
Author(s):  
Mao Horio ◽  
Mami Kohno ◽  
Yuko Fujita ◽  
Tamaki Ishima ◽  
Ran Inoue ◽  
...  
Keyword(s):  
Serine Racemase ◽  
Knock Out ◽  
Peripheral Organs ◽  
Knock Out Mice ◽  
The Brain

scholarly journals NMDA- and  -Amyloid1-42-Induced Neurotoxicity Is Attenuated in Serine Racemase Knock-Out Mice

2008 ◽  
Vol 28 (53) ◽  
pp. 14486-14491 ◽  
Author(s):  
R. Inoue ◽  
K. Hashimoto ◽  
T. Harai ◽  
H. Mori
Keyword(s):  
Serine Racemase ◽  
Knock Out ◽  
Knock Out Mice

Mast cell proteases protect against histaminergic itch and attenuate tissue injury pain responses

2016 ◽  
Vol 12 (1) ◽  
pp. 126-126
Author(s):  
E.I. Magnúsdóttir ◽  
M. Grujic ◽  
G. Pejler ◽  
M.C. Lagerström
Keyword(s):  
Mast Cell ◽  
Tissue Injury ◽  
Protective Role ◽  
Human Mast Cell ◽  
Total Protein Content ◽  
Formalin Injection ◽  
Knock Out ◽  
And Gender ◽  
Knock Out Mice ◽  
Mouse Mast Cell

Abstract Aims Mast cell proteases comprise up to 25% of the total protein content within mast cells and have various functions that are still poorly understood but can be either protective or pro-inflammatory.Three ofthose proteases in mice have been identified as the closest functional homologues to human mast cell proteases, and in this currently ongoing study we are investigating if they play a role in itch and tissue injury pain, and if they do, what the possible mechanism behind that could be. Methods Knock-out mice were generated, lacking either one or multiple proteases. To evaluate itch, the animals (n = 8–10) were injected intradermally with histaminergic (histamine, compound 48/80) and non-histaminergic (protease activated receptor 2 (PAR2) agonist, chloroquine) pruritic substances and their itch behavior over 1 h scored. Formalin injection (n = 20) in the hind paw was used as a model for tissue injury pain, where the mice were monitored for pain behavior for 1 h following the injection. Age and gender matched C57BL/6 mice were used as controls. Results Mice lacking three of the proteases had twice as many scratching episodes in response to histamine (P =0.016) and compound 48/80 (P =0.034) than controls. The non-histaminergic substances chloroqine and PAR2 are more potent pruritogens but difference was not seen in itch levels between genotypes. Furthermore, the protease-deficient mice exhibited a more pronounced pain response during the inflammatory stage (10–60 min after formalin injection, P = 0.025) of the tissue injury test. Conclusions The mouse mast cell proteases have a protective role against histaminergic itch and in acute inflammation following a tissue injury. The exact mechanism remains unclear at present as the proteases cleave a variety of different pro-inflammatory substrates and can act in complimentary fashion by cleaving the same substrates but at different sites.

Increased glyoxalase-1 levels in Fkbp5 knock-out mice caused by Glo1 gene duplication

2013 ◽  
Vol 46 (06) ◽  
Author(s):  
LK Kollmannsberger ◽  
NC Gassen ◽  
A Bultmann ◽  
J Hartmann ◽  
P Weber ◽  
...  
Keyword(s):  
Gene Duplication ◽  
Knock Out ◽  
Glyoxalase 1 ◽  
Knock Out Mice

Functional characterization of the H+/K+ ATPase in wild type and gastrin knock-out mice

2007 ◽  
Vol 45 (05) ◽  
Author(s):  
A Schnur ◽  
P Hegyi ◽  
V Venglovecz ◽  
Z Rakonczay ◽  
I Ignáth ◽  
...  
Keyword(s):  
Functional Characterization ◽  
Wild Type ◽  
Knock Out ◽  
Knock Out Mice
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