scholarly journals Dipeptidyl Peptidase IV Inhibitor MK-0626 Attenuates Pancreatic Islet Injury in Tacrolimus-Induced Diabetic Rats

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e100798 ◽  
Author(s):  
Long Jin ◽  
Sun Woo Lim ◽  
Kyoung Chan Doh ◽  
Shang Guo Piao ◽  
Jian Jin ◽  
...  
Keyword(s):  
Pancreatic Islet ◽  
Dipeptidyl Peptidase ◽  
Diabetic Rats ◽  
Dipeptidyl Peptidase Iv

scholarly journals Dipeptidyl Peptidase IV Inhibitor MK-0626 Attenuates Pancreatic Islet Injury in Tacrolimus-Induced Diabetic Rats

2014 ◽  
Vol 33 (2) ◽  
pp. A6-A7
Author(s):  
Sun Woo Lim ◽  
Jin Long ◽  
Doh Kyoung Chan ◽  
Jin Jian ◽  
Piao Shang Guo ◽  
...  
Keyword(s):  
Pancreatic Islet ◽  
Dipeptidyl Peptidase ◽  
Diabetic Rats ◽  
Dipeptidyl Peptidase Iv

Antihyperglycemic effects of ASP8497 in streptozotocin-nicotinamide induced diabetic rats: comparison with other dipeptidyl peptidase-IV inhibitors

2009 ◽  
Vol 61 (5) ◽  
pp. 899-908 ◽  
Author(s):  
Atsuo Tahara ◽  
Akiko Matsuyama-Yokono ◽  
Ryosuke Nakano ◽  
Yuka Someya ◽  
Masahiko Hayakawa ◽  
...  
Keyword(s):  
Dipeptidyl Peptidase ◽  
Diabetic Rats ◽  
Dipeptidyl Peptidase Iv ◽  
Dipeptidyl Peptidase Iv Inhibitors

scholarly journals Dipeptidyl Peptidase IV-Resistant [D-Ala2]Glucose-Dependent Insulinotropic Polypeptide (GIP) Improves Glucose Tolerance in Normal and Obese Diabetic Rats

Diabetes ◽  
2002 ◽  
Vol 51 (3) ◽  
pp. 652-661 ◽  
Author(s):  
S. A. Hinke ◽  
R. W. Gelling ◽  
R. A. Pederson ◽  
S. Manhart ◽  
C. Nian ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Dipeptidyl Peptidase ◽  
Diabetic Rats ◽  
Dipeptidyl Peptidase Iv ◽  
Obese Diabetic Rats

scholarly journals Dipeptidyl peptidase IV is sorted to the secretory granules in pancreatic islet A-cells.

1993 ◽  
Vol 41 (1) ◽  
pp. 81-88 ◽  
Author(s):  
M D Poulsen ◽  
G H Hansen ◽  
E Dabelsteen ◽  
P E Høyer ◽  
O Norén ◽  
...  
Keyword(s):  
Pancreatic Islet ◽  
Endocrine Cells ◽  
Polyclonal Antibodies ◽  
Secretory Granules ◽  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase Iv ◽  
Second Primary ◽  
Double Labeling ◽  
A Cells ◽  
Granule Membrane

Dipeptidyl peptidase IV (DP IV:EC 3.4.14.5) was localized in endocrine cells of pig pancreas by immunohistochemical and enzyme histochemical methods. Immunolight microscopy with both monoclonal and polyclonal antibodies demonstrated DP IV immunoreactivity in cells located in the peripheral part of the islets of Langerhans. The antigen is enzymatically active, as shown by enzyme histochemical analysis with a synthetic DP IV substrate. By immunoelectron microscopy (immunogold labeling), the labeling of DP IV in the islets was associated with the secretory granules of the A-cells, as identified by double labeling using a monoclonal glucagon antibody as the second primary antibody. These results show that DP IV is sorted to secretory granules in the pig pancreatic islet A-cells. Furthermore, this secretory granule enzyme, as opposed to intestinal brush border DP IV, is suggested to be a soluble protein, since the gold particles appear all over the granules and are not specifically associated with the granule membrane.

Dipeptidyl Peptidase IV Inhibitor Attenuates Kidney Injury in Streptozotocin-Induced Diabetic Rats

2011 ◽  
Vol 340 (2) ◽  
pp. 248-255 ◽  
Author(s):  
Wei Jing Liu ◽  
Shu Hua Xie ◽  
Yu Ning Liu ◽  
Won Kim ◽  
Heung Yong Jin ◽  
...  
Keyword(s):  
Kidney Injury ◽  
Dipeptidyl Peptidase ◽  
Diabetic Rats ◽  
Dipeptidyl Peptidase Iv

Improvement of glycemic control in streptozotocin-induced diabetic rats by Atlantic salmon skin gelatin hydrolysate as the dipeptidyl-peptidase IV inhibitor

2015 ◽  
Vol 6 (6) ◽  
pp. 1887-1892 ◽  
Author(s):  
C. H. Hsieh ◽  
T. Y. Wang ◽  
C. C. Hung ◽  
M. C. Chen ◽  
K. C. Hsu
Keyword(s):  
Insulin Secretion ◽  
Glycemic Control ◽  
Atlantic Salmon ◽  
Dipeptidyl Peptidase ◽  
Diabetic Rats ◽  
Dipeptidyl Peptidase Iv ◽  
Dpp Iv ◽  
Gelatin Hydrolysate

FSGH has the function of inhibiting GLP-1 degradation by DPP-IV, resulting in the enhancement of insulin secretion and improvement of glycemic control in STZ-induced diabetic rats.

scholarly journals Dipeptidyl Peptidase IV Inhibitor Treatment Stimulates  -Cell Survival and Islet Neogenesis in Streptozotocin-Induced Diabetic Rats

Diabetes ◽  
2003 ◽  
Vol 52 (3) ◽  
pp. 741-750 ◽  
Author(s):  
J. A. Pospisilik ◽  
J. Martin ◽  
T. Doty ◽  
J. A. Ehses ◽  
N. Pamir ◽  
...  
Keyword(s):  
Cell Survival ◽  
Dipeptidyl Peptidase ◽  
Diabetic Rats ◽  
Dipeptidyl Peptidase Iv ◽  
Islet Neogenesis ◽  
Inhibitor Treatment
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