scholarly journals Morbillivirus V Proteins Exhibit Multiple Mechanisms to Block Type 1 and Type 2 Interferon Signalling Pathways

PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e57063 ◽  
Author(s):  
Senthil K. Chinnakannan ◽  
Sambit K. Nanda ◽  
Michael D. Baron
Keyword(s):  
Signalling Pathways ◽  
Block Type ◽  
Interferon Signalling

scholarly journals Influence of Parasite Load on the Ability of Type 1 T Cells To Control Leishmania major Infection

2002 ◽  
Vol 70 (2) ◽  
pp. 498-503 ◽  
Author(s):  
Brian Hondowicz ◽  
Phillip Scott
Keyword(s):  
Cell Population ◽  
Leishmania Major ◽  
Parasite Load ◽  
Interleukin 12 ◽  
Block Type ◽  
Cell Transfer ◽  
Parasite Replication ◽  
High Parasite

ABSTRACT BALB/c mice infected with Leishmania major developed a type 2 immune response which failed to control parasite replication. We found that scid mice that received splenocytes from BALB/c mice that had been infected for 3 weeks with L. major (a type 2 cell population) and that were subsequently infected with L. major were protected when they were treated with interleukin 12 (IL-12). In contrast, IL-12 was ineffective at protecting BALB/c mice infected for 3 weeks, suggesting that a high parasite load regulates the development of protective immunity. To determine how this regulation operates, we performed a series of adoptive transfers of naïve, type 1 or type 2 splenocytes into scid mice. The recipient scid mice were infected either for 5 weeks prior to cell transfer (and thus had a high parasite load) or at the time of cell transfer. scid mice that were infected for 5 weeks and received a type 1 cell population were able to cure their lesions. However, when 5-week-infected scid mice received both type 1 and 2 cell populations, they were unable to control their infections. In contrast, the same type 1 and 2 cells transferred to naïve scid mice, which were subsequently infected, provided protection. In addition, we found that naïve cells mediated protection in scid mice with established lesions. These results show that high parasite numbers do not block type 1 protective responses or the development of type 1 responses. Instead, the influence of a high parasite load is dependent on the presence of a type 2 cell population.

scholarly journals Activation of the innate immune response and interferon signalling in myotonic dystrophy type 1 and type 2 cataracts

2011 ◽  
Vol 21 (4) ◽  
pp. 852-862 ◽  
Author(s):  
Jeremy D. Rhodes ◽  
Martin C. Lott ◽  
Sarah L. Russell ◽  
Vincent Moulton ◽  
Julie Sanderson ◽  
...  
Keyword(s):  
Immune Response ◽  
Myotonic Dystrophy ◽  
Innate Immune Response ◽  
Innate Immune ◽  
Myotonic Dystrophy Type 1 ◽  
Myotonic Dystrophy Type ◽  
Interferon Signalling

scholarly journals Experimental Studies on a Powder-Snow Avalanche

1989 ◽  
Vol 13 ◽  
pp. 129-134 ◽  
Author(s):  
K. Kawada ◽  
K. Nishimura ◽  
N. Maeno
Keyword(s):  
Large Scale ◽  
Impact Force ◽  
Experimental Studies ◽  
Block Type ◽  
Impact Forces ◽  
Wave Forms ◽  
The Impact ◽  
Force Data

To make clear the structure and behaviour of a large-scale avalanche, the impact force-data obtained in the avalanche project of 1972–78 were analysed in detail. The wave forms of impact forces are classified into two types. Type 1 is composed of many separate spikes each of which represents the collision of a snow block. Type 2 has wider peaks, caused by collisons of snow blocks mixed with fluidized snow. Most of the type 1 peaks were in the width range corresponding to 0.005–0.01 s duration, and most type 2 peaks fell into the 0.02–0.1 s range.The internal velocities of an avalanche were estimated by calculating cross-correlation spectra for a time series of impact-force records. It was discovered that these internal velocities varied from 10 to 50 m/s over time. The mean distance between snow blocks was found to be in the range 1.6–5.4 m in a type 1 avalanche, and between 0.7 and 3 m in type 2 avalanches. Sizes of snow blocks or snow clouds of type 1 and type 2 were in ranges 0.26–0.52 and 0.37–1.9 m, respectively.This paper also reports on the project created to initiate artificial powder-snow avalanches in the Shiai-dani area and to make systematic observations of a variety of physical aspects. Results obtained in 1988 for both artificial and natural avalanches are given.

scholarly journals Experimental Studies on a Powder-Snow Avalanche

1989 ◽  
Vol 13 ◽  
pp. 129-134 ◽  
Author(s):  
K. Kawada ◽  
K. Nishimura ◽  
N. Maeno
Keyword(s):  
Large Scale ◽  
Impact Force ◽  
Experimental Studies ◽  
Block Type ◽  
Impact Forces ◽  
Wave Forms ◽  
The Impact ◽  
Force Data

To make clear the structure and behaviour of a large-scale avalanche, the impact force-data obtained in the avalanche project of 1972–78 were analysed in detail. The wave forms of impact forces are classified into two types. Type 1 is composed of many separate spikes each of which represents the collision of a snow block. Type 2 has wider peaks, caused by collisons of snow blocks mixed with fluidized snow. Most of the type 1 peaks were in the width range corresponding to 0.005–0.01 s duration, and most type 2 peaks fell into the 0.02–0.1 s range. The internal velocities of an avalanche were estimated by calculating cross-correlation spectra for a time series of impact-force records. It was discovered that these internal velocities varied from 10 to 50 m/s over time. The mean distance between snow blocks was found to be in the range 1.6–5.4 m in a type 1 avalanche, and between 0.7 and 3 m in type 2 avalanches. Sizes of snow blocks or snow clouds of type 1 and type 2 were in ranges 0.26–0.52 and 0.37–1.9 m, respectively. This paper also reports on the project created to initiate artificial powder-snow avalanches in the Shiai-dani area and to make systematic observations of a variety of physical aspects. Results obtained in 1988 for both artificial and natural avalanches are given.

Type 2 Diabetes Overtakes Type 1 in Hispanic Girls

2008 ◽  
Vol 38 (15) ◽  
pp. 18
Author(s):  
SHERRY BOSCHERT
Keyword(s):  
Type 2 Diabetes

Molecular analysis of FVIII gene in severe HA patients of Costa Rica

2010 ◽  
Vol 30 (S 01) ◽  
pp. S150-S152
Author(s):  
G. Jiménez-Cruz ◽  
M. Mendez ◽  
P. Chaverri ◽  
P. Alvarado ◽  
W. Schröder ◽  
...  
Keyword(s):  
Factor Viii ◽  
Coagulation Factor ◽  
Costa Rican ◽  
Factor Viii Gene ◽  
Intron 22 Inversion ◽  
Intron 1 ◽  
Polymerase Chain ◽  
Inversion Analysis

SummaryHaemophilia A (HA) is X-chromosome linked bleeding disorders caused by deficiency of the coagulation factor VIII (FVIII). It is caused by FVIII gene intron 22 inversion (Inv22) in approximately 45% and by intron 1 inversion (Inv1) in 5% of the patients. Both inversions occur as a result of intrachromosomal recombination between homologous regions, in intron 1 or 22 and their extragenic copy located telomeric to the FVIII gene. The aim of this study was to analyze the presence of these mutations in 25 HA Costa Rican families. Patients, methods: We studied 34 HA patients and 110 unrelated obligate members and possible carriers for the presence of Inv22or Inv1. Standard analyses of the factor VIII gene were used incl. Southern blot and long-range polymerase chain reaction for inversion analysis. Results: We found altered Inv22 restriction profiles in 21 patients and 37 carriers. It was found type 1 and type 2 of the inversion of Inv22. During the screening for Inv1 among the HA patient, who were Inv22 negative, we did not found this mutation. Discussion: Our data highlight the importance of the analysis of Inv22 for their association with development of inhibitors in the HA patients and we are continuous searching of Inv1 mutation. This knowledge represents a step for genetic counseling and prevention of the inhibitor development.

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