scholarly journals Telomere Length and Long-Term Endurance Exercise: Does Exercise Training Affect Biological Age? A Pilot Study

PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e52769 ◽  
Author(s):  
Ida Beate Ø. Østhus ◽  
Antonella Sgura ◽  
Francesco Berardinelli ◽  
Ingvild Vatten Alsnes ◽  
Eivind Brønstad ◽  
...  
2015 ◽  
Vol 5 (1) ◽  
pp. 51-63 ◽  
Author(s):  
Kerry L. Hildreth ◽  
Rachael E. Van Pelt ◽  
Kerrie L. Moreau ◽  
Jim Grigsby ◽  
Karin F. Hoth ◽  
...  

Aims: To examine the effects of pioglitazone or endurance exercise training on cognitive function in older adults with mild cognitive impairment (MCI) and insulin resistance. Methods: Seventy-eight adults (mean age ± SD: 65 ± 7 years) with central obesity and MCI were randomized to 6 months of endurance exercise, pioglitazone or control. Results: Sixty-six participants completed the study. Exercise training did not significantly increase peak oxygen uptake compared to control (p = 0.12). Compared to control, insulin resistance improved in the pioglitazone group (p = 0.002) but not in the exercise group (p = 0.25). There was no measureable effect of pioglitazone or exercise on cognitive performance compared to control. Conclusion: In this pilot study, pioglitazone improved insulin resistance but not cognitive performance in older adults with MCI and insulin resistance.


2020 ◽  
Vol 129 (4) ◽  
pp. 873-879 ◽  
Author(s):  
Barbara Hernando ◽  
Marta Gil-Barrachina ◽  
Elena Tomás-Bort ◽  
Ignacio Martinez-Navarro ◽  
Eladio Collado-Boira ◽  
...  

Habitual ultra-endurance exercise seems to promote telomere length maintenance, especially at older ages. In addition, the beneficial effect of ultra-endurance training on biological aging is higher in ultra-trail runners who have been engaged to ultra-endurance training during many years. Finally, and for the first time, this study shows that the SOD2 rs4880 polymorphism has a significant impact on telomere length, as well as on acute inflammatory response to a 107-km trail race.


2012 ◽  
Vol 25 (6) ◽  
pp. 651-656 ◽  
Author(s):  
Jun Sugawara ◽  
Nobuhiko Akazawa ◽  
Asako Miyaki ◽  
Youngju Choi ◽  
Yoko Tanabe ◽  
...  

2000 ◽  
Vol 64 (11) ◽  
pp. 848-850 ◽  
Author(s):  
Hitoshi Adachi ◽  
Shigeki Sakurai ◽  
Masaaki Tanehata ◽  
Shigeru Oshima ◽  
Koichi Taniguchi

Author(s):  
W. Todd Cade ◽  
Dominic N. Reeds ◽  
Linda R. Peterson ◽  
Kathryn L. Bohnert ◽  
Rachel A. Tinius ◽  
...  

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