Troublesome Heterotopic Ossification after Central Nervous System Damage: A Survey of 570 Surgeries

A biosignal is used as a control signal for electrical stimulation to restore weakened muscle function due to damage to the central nervous system. In patients with central nervous system damage, sufficient muscle contraction does not occur spontaneously. In this case, applying electrical stimulation can cause normal muscle contraction. However, it is necessary to remove the electrical stimulation artifact caused by the electrical stimulation. This paper describes a system design that removes electrical stimulation artifact in real time using a Cortex-M4-based STM32F processor. The STM32F is a very advantageous MCU for such DSPs, especially because it has a built-in floating point operator. Using STM32F's various high-performance peripherals (12-bit parallel ADC and 12-bit DAC, UART, Timer), an optimized embedded system was implemented.In this paper, the simulated and real-time results were compared and evaluated with the designed fir filter. In addition, the performance of the filter was evaluated through frequency analysis. As a result, it was verified that a high-performance 32-bit STM32F with floating point calculator and various peripherals is suitable for real-time signal processing

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Mycobacterium of tuberculosis with defective cell wall, determined in the brain of the biological model with spongional changes

Reports of Vinnytsia National Medical University ◽

10.31393/reports-vnmedical-2019-23(1)-02 ◽

2019 ◽

Vol 23 (1) ◽

pp. 12-19

Author(s):

O.P. Lysenko ◽

V.V. Vlasenko ◽

H.K. Palii ◽

I.H. Vlasenko ◽

O.A. Nazarchuk

Keyword(s):

Central Nervous System ◽

Cell Wall ◽

Nervous System ◽

Mycobacterium Tuberculosis ◽

Brain Damage ◽

Molecular Genetic Study ◽

Central Nervous System Damage ◽

Infectious Dose ◽

Microbiological Methods ◽

The Brain

Mycobacterium tuberculosis is endowed with resistance to adverse factors and rapidly forms drug resistance. The aim is to study of the connection of tuberculosis infection and the development of brain damage with signs of spongymorphic changes. There were investigated canned 10% formalin fragments of the brain of 2 goats with signs of central nervous system damage by histological, microbiological methods. For microbiological examination, 3–5 years brain samples after were sowed on the MycСel DW nutrient medium with a growth stimulator. The molecular genetic study was performed using a polymerase chain reaction on a Molecular Imager GelDoc TM XR + (BioRad) device. The polypeptide profile was studied electrophoretically. In the goats, who died with symptoms of central nervous system damage, spongiform changes were detected in the brain. In the brain samples, DNA and mycobacterium tuberculosis with a defective cell wall have been detected, accumulation of mycobacterial antigens has been observed in the cells of the brain and in the intercellular space. Despite the fact that brain samples were in 10% formalin for 1 month, 3 years and 5 years, in all cases mycobacterium tuberculosis with a defective cell wall was isolated. Their viability was comparable to the infectiousness of prions. The isolation of mycobacterium tuberculosis with a defective cell wall from the brain did not differ in morphology and polypeptide composition from isolates from tuberculin, FLK-BLV, lymph nodes of cows, patients with tuberculosis. This indicates a high probability that mycobacterial infection, depending on the infectious dose, the characteristics of the strain and host genome, as well as the state of the immune system, can cause oncogenic action, cause active tuberculosis, brain damage, and the cardiovascular system.

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The central nervous system is a target of acute graft versus host disease in mice

Blood ◽

10.1182/blood-2012-09-456590 ◽

2013 ◽

Vol 121 (10) ◽

pp. 1906-1910 ◽

Cited By ~ 29

Author(s):

Steffen Hartrampf ◽

Jarrod A. Dudakov ◽

Linda K. Johnson ◽

Odette M. Smith ◽

Jennifer Tsai ◽

...

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Central Nervous System Damage ◽

Graft Versus Host ◽

Alloreactive T Cells ◽

Key Points ◽

The Central Nervous System ◽

Anxiety Behavior ◽

Direct Target ◽

Acute Graft

Key Points The central nervous system can be a direct target of alloreactive T cells during GVHD. Central nervous system damage in mouse models of GVHD lead to deficits in learning and increased anxiety behavior.

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LONGITUDINAL STUDY OF THE INCIDENCE OF CENTRAL NERVOUS SYSTEM DAMAGE FOLLOWING ERYTHROBLASTOSIS FETALIS

PEDIATRICS ◽

10.1542/peds.14.4.346 ◽

1954 ◽

Vol 14 (4) ◽

pp. 346-350

Author(s):

MARGARET H. JONES ◽

RUSSELL SANDS ◽

CAROL B. HYMAN ◽

PHILLIP STURGEON ◽

FREMONT P. KOCH

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Longitudinal Study ◽

Central Nervous System Involvement ◽

Newborn Period ◽

Central Nervous System Damage ◽

System Involvement ◽

Childrens Hospital ◽

Infancy And Childhood

One hundred unselected cases of erythroblastosis fetalis treated at Childrens Hospital in the newborn period have been followed from six months to five years in an effort to evaluate the relation of central nervous system signs in the newborn period to neuromuscular handicap and overall development later. Of those showing no central nervous system signs in the newborn period 4% showed definite abnormality later. Of those showing equivocal signs in the newborn period 33% showed definite abnormality later. Of those having definite signs early, 100% continued to show abnormality in infancy and childhood. There was no relation of the severity of the signs in the newborn period to the severity of the later handicap. It is suggested, therefore, that one cannot be certain of the later normality of an infant showing no definite or equivocal central nervous system involvement in the newborn period. Careful following of all erythroblastotic infants until six to eight years of age or longer is advisable.

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Design, fabrication, and testing of a bioprinted nerve graft

10.32469/10355/71260 ◽

2016 ◽

Author(s):

◽

Christopher M. Owens

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Nerve Graft ◽

Loss Of Function ◽

Vitro Assay ◽

Central Nervous System Damage ◽

In Vivo Animal Model ◽

The Central Nervous System

Injuries to nerves vary in their consequences, from weakened sensation and motor function to partial or complete paralysis. In the latter case, affecting about twenty thousand Americans yearly, the injury is debilitating and results in a significant decrease in quality of life. Currently there is no effective treatment for damage to the central nervous system, in particular the spinal cord. Compared to the injuries to the central nervous system, damage in the peripheral nerves, is more common, with about sixty thousand occurrences annually. The cost of associated surgical procedures and due to loss of function is in the billions. In this thesis we present work towards the construction and testing of a fully cellular, patented nerve graft, one amongst the first of its kind. For the fabrication of the graft we are the first to employ bioprinting (either implemented through a special purpose 3D bioprinter or manually), a novel tissue engineering method rapidly gaining acceptance and utility. We first review the status of bioprinting. We then detail the fabrication process. Next we report on the testing of the graft in an in vivo animal model through electrophysiology and histology. This is followed by the introduction of a novel in vitro model, aimed at providing a fast, inexpensive and reliable method to test engineered nerve grafts. We describe our work on the optimization of the in vitro assay and then the testing of the graft using the optimized assay. We conclude with a summary of our accomplishments and make suggestions for some exciting future applications of our approach.

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Cyclic AMP Concentration and Enzyme Activities of Cerebrospinal Fluid in Patients with Epilepsy or Central Nervous System Damage

European Neurology ◽

10.1159/000114668 ◽

1975 ◽

Vol 13 (2) ◽

pp. 123-130 ◽

Cited By ~ 34

Author(s):

V.V. Myllylä ◽

E.R. Heikkinen ◽

H. Vapaatalo ◽

E. Hokkanen

Keyword(s):

Central Nervous System ◽

Cerebrospinal Fluid ◽

Nervous System ◽

Cyclic Amp ◽

Enzyme Activities ◽

Central Nervous System Damage ◽

Patients With Epilepsy

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Different roles of soluble CD40 ligand in central nervous system damage

Neurological Research ◽

10.1080/01616412.2020.1716469 ◽

2020 ◽

Vol 42 (5) ◽

pp. 372-378

Author(s):

Li Du ◽

Haoxiao Chang ◽

Yuzhen Wei ◽

Xinghu Zhang ◽

Linlin Yin

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Cd40 Ligand ◽

Soluble Cd40 Ligand ◽

Central Nervous System Damage

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Lanthanum chloride induces autophagy in rat hippocampus through ROS-mediated JNK and AKT/mTOR signaling pathways

Metallomics ◽

10.1039/c8mt00295a ◽

2019 ◽

Vol 11 (2) ◽

pp. 439-453 ◽

Cited By ~ 4

Author(s):

Xiang Gao ◽

Jinghua Yang ◽

Yingqi Li ◽

Miao Yu ◽

Shiyu Liu ◽

...

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Signaling Pathways ◽

Learning And Memory ◽

Memory Impairment ◽

Mtor Signaling ◽

Lanthanum Chloride ◽

Rat Hippocampus ◽

Central Nervous System Damage

Lanthanum (La) can cause central nervous system damage in rats and lead to learning and memory impairment, but the relevant mechanisms have not been fully elucidated.

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