scholarly journals Cancer Testis Antigen Vaccination Affords Long-Term Protection in a Murine Model of Ovarian Cancer

PLoS ONE ◽  
2010 ◽  
Vol 5 (5) ◽  
pp. e10471 ◽  
Author(s):  
Maurizio Chiriva-Internati ◽  
Yuefei Yu ◽  
Leonardo Mirandola ◽  
Marjorie R. Jenkins ◽  
Caroline Chapman ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Murine Model ◽  
Cancer Testis Antigen ◽  
Cancer Testis

Cancer-testis antigen expression is shared between epithelial ovarian cancer tumors

2014 ◽  
Vol 133 ◽  
pp. 95
Author(s):  
A.E. Garcia-Soto ◽  
J.A. Lucci ◽  
E. Podack ◽  
T. Schreiber ◽  
E.D. Schroeder
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Antigen Expression ◽  
Cancer Testis Antigen ◽  
Cancer Testis

scholarly journals Combined TIM-3 blockade and CD137 activation affords the long-term protection in a murine model of ovarian cancer

2013 ◽  
Vol 11 (1) ◽  
pp. 215 ◽  
Author(s):  
Zhiqiang Guo ◽  
Dali Cheng ◽  
Zhijun Xia ◽  
Meng Luan ◽  
Liangliang Wu ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Murine Model

Cancer-testis antigen expression is shared between epithelial ovarian cancer tumors

2017 ◽  
Vol 145 (3) ◽  
pp. 413-419 ◽  
Author(s):  
Arlene E. Garcia-Soto ◽  
Taylor Schreiber ◽  
Natasa Strbo ◽  
Parvin Ganjei-Azar ◽  
Feng Miao ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Antigen Expression ◽  
Cancer Testis Antigen ◽  
Cancer Testis

91 THE DEVELOPMENT OF MURINE TUMOR ANIMAL MODELS FOR OVARIAN CANCER INCORPORATING A TUMOR-SPECIFIC SPERM 17/CANCER TESTIS ANTIGEN.

2006 ◽  
Vol 54 (1) ◽  
pp. S272.2-S272
Author(s):  
A. S. Kyle ◽  
F. Grizzi ◽  
W. Wan ◽  
S. H. Micheal ◽  
D. B. Lowe ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Animal Models ◽  
Cancer Testis Antigen ◽  
Murine Tumor ◽  
Cancer Testis

scholarly journals Cancer testis antigen XAGE-1 is a promising marker for the diagnosis and treatment of ovarian cancer

2021 ◽  
Vol 14 (5) ◽  
pp. 710-715
Author(s):  
Maysaa Ghazi Jumaa https://orcid.org ◽  
Mukhallad Abdul-Kareem Ramadhan https://orcid.org ◽  
◽  
Keyword(s):  
Ovarian Cancer ◽  
Diagnosis And Treatment ◽  
Cancer Testis Antigen ◽  
Cancer Testis

BORIS, a novel cancer-testis antigen, is a potential target for immunotherapy in epithelial ovarian cancer

2005 ◽  
Vol 23 (16_suppl) ◽  
pp. 9673-9673
Author(s):  
J. A. Villella ◽  
F. Qian ◽  
B. Keitz ◽  
D. Driscoll ◽  
J. Skipper ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Cancer Testis Antigen ◽  
Potential Target ◽  
Cancer Testis

scholarly journals Comprehensive Analysis of Mouse Cancer/Testis Antigen Functions in Cancer Cells and Roles of TEKT5 in Cancer Cells and Testicular Germ Cells

2019 ◽  
Vol 39 (17) ◽  
Author(s):  
Nana Aoki ◽  
Yasuhisa Matsui
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Germ Cells ◽  
Comprehensive Analysis ◽  
Nuclear Accumulation ◽  
Ovarian Cancer Cells ◽  
Cancer Testis Antigen ◽  
Human Genes ◽  
Cancer Testis

ABSTRACT The cancer/testis antigen (CTA) genes were identified as human genes preferentially expressed in cancer cells and testis, but the contribution of CTAs to cancer and male germ cell development is unclear. In this study, we comprehensively examined mouse CTA functions and found that the majority of CTAs are involved in growth and/or survival of cancer cells. We focused on one mouse CTA gene, Tekt5, for its detailed functional analysis. Tekt5 knockdown (KD) in ovarian cancer cells caused G1 arrest and apoptosis, and p27kip1 was concomitantly upregulated. Tekt5 KD also resulted in decreased levels of acetylated α-tubulin and subsequent fragmentation of β-III-tubulin, upregulation of HDAC6 that deacetylates α-tubulin, and nuclear accumulation of SMAD3 that induces p27kip1 expression. Because depolymerization of tubulin is known to cause translocation of SMAD3 to the nucleus, these results together suggested that TEKT5 negatively regulates Hdac6 expression and consequently maintains cell cycle via stabilization of tubulin. We also found that the number of spermatids was significantly decreased and acetylated α-tubulin levels were decreased in vivo by KD of Tekt5 in testis. Because acetylated α-tubulin is required for sperm morphogenesis, these results suggest that TEKT5 is necessary for spermiogenesis via maintenance of acetylated α-tubulin levels.

scholarly journals A novel cancer/testis antigen KP-OVA-52 identified by SEREX in human ovarian cancer is regulated by DNA methylation

2012 ◽  
Vol 41 (3) ◽  
pp. 1139-1147 ◽  
Author(s):  
KANG-MI KIM ◽  
MYUNG-HA SONG ◽  
MIN-JU KIM ◽  
SAYEEMA DAUDI ◽  
ANTHONY MILIOTTO ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Dna Methylation ◽  
Human Ovarian Cancer ◽  
Cancer Testis Antigen ◽  
Cancer Testis
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