scholarly journals WNT4/β-Catenin Pathway Maintains Female Germ Cell Survival by Inhibiting Activin βB in the Mouse Fetal Ovary

PLoS ONE ◽  
2010 ◽  
Vol 5 (4) ◽  
pp. e10382 ◽  
Author(s):  
Chia-Feng Liu ◽  
Keith Parker ◽  
Humphrey H.-C. Yao
Keyword(s):  
Germ Cell ◽  
Cell Survival ◽  
Female Germ Cell ◽  
Fetal Ovary

scholarly journals Wnt4/β-catenin signaling is required for germ cell survival in the fetal ovary

2009 ◽  
Vol 331 (2) ◽  
pp. 497 ◽  
Author(s):  
Chia-Feng Liu ◽  
Keith Parker ◽  
Humphrey H.-C. Yao
Keyword(s):  
Germ Cell ◽  
Cell Survival ◽  
Fetal Ovary

scholarly journals Single cell RNA sequencing reveals regulation of fetal ovary development in the monkey (Macaca fascicularis)

2020 ◽  
Author(s):  
Zheng-Hui Zhao ◽  
Chun-Yang Li ◽  
Tie-Gang Meng ◽  
Yan Wang ◽  
Wen-Bo Liu ◽  
...  
Keyword(s):  
Germ Cell ◽  
Single Cell ◽  
Rna Sequencing ◽  
Germ Cells ◽  
Leydig Cells ◽  
Macaca Fascicularis ◽  
Ovary Development ◽  
Single Cell Rna Sequencing ◽  
Female Germ Cell ◽  
Fetal Ovary

ABSTRACTGerm cells are vital for reproduction and heredity. However, the mechanisms underlying female germ cell development in primates, especially in late embryonic stages, remain elusive. Here, we performed single-cell RNA sequencing of 12471 cells from whole fetal ovaries, and explored the communications between germ cells and niche cells. We depicted the two waves of oogenesis at single cell resolution and demonstrated that progenitor theca cells exhibit similar characteristics to Leydig cells in fetal monkey ovaries. Notably, we found that ZGLP1 displays differentially expressed patterns between mouse and monkey, which is not overlapped with NANOG in monkey germ cells, suggesting its role in meiosis entry but not in activating oogenic program in primates. Furthermore, the majority of germ cell clusters that highly expressed PRDM9 and SPO11 might undergo apoptosis after cyst breakdown, leading to germ cell attrition. Overall, our work provides new insights into the molecular and cellular basis of primate fetal ovary development at single-cell resolution.

The Role of Wnt4/beta-Catenin Signaling in Maintaining Germ Cell Survival in the Fetal Ovary.

2009 ◽  
Vol 81 (Suppl_1) ◽  
pp. 175-175 ◽  
Author(s):  
Chia-Feng Liu ◽  
Keith Parker ◽  
Humphrey Huang-Chang Yao
Keyword(s):  
Germ Cell ◽  
Cell Survival ◽  
Beta Catenin ◽  
Fetal Ovary

scholarly journals Single-cell RNA sequencing reveals regulation of fetal ovary development in the monkey (Macaca fascicularis)

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Zheng-Hui Zhao ◽  
Chun-Yang Li ◽  
Tie-Gang Meng ◽  
Yan Wang ◽  
Wen-Bo Liu ◽  
...  
Keyword(s):  
Germ Cell ◽  
Single Cell ◽  
Rna Sequencing ◽  
Germ Cells ◽  
Leydig Cells ◽  
Macaca Fascicularis ◽  
Ovary Development ◽  
Single Cell Rna Sequencing ◽  
Female Germ Cell ◽  
Fetal Ovary

AbstractGerm cells are vital for reproduction and heredity. However, the mechanisms underlying female germ cell development in primates, especially in late embryonic stages, remain elusive. Here, we performed single-cell RNA sequencing of 12,471 cells from whole fetal ovaries, and explored the communications between germ cells and niche cells. We depicted the two waves of oogenesis at single-cell resolution and demonstrated that progenitor theca cells exhibit similar characteristics to Leydig cells in fetal monkey ovaries. Notably, we found that ZGLP1 displays differentially expressed patterns between mouse and monkey, which is not overlapped with NANOG in monkey germ cells, suggesting its role in meiosis entry but not in activating oogenic program in primates. Furthermore, the majority of germ cell clusters that sharply express PRDM9 and SPO11 might undergo apoptosis after cyst breakdown, leading to germ cell attrition. Overall, our work provides new insights into the molecular and cellular basis of primate fetal ovary development at single-cell resolution.

The case of prenatal diagnosis of a germ cell tumor of the fetal ovary

2018 ◽  
Author(s):  
N.N. Bondarenko, E.Yu. Andreeva , N.B. Filippova
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Ovarian Tumor ◽  
Ultrasound Examination ◽  
Abdominal Mass ◽  
Abdominal Cavity ◽  
Cell Tumor ◽  
Fetal Ovary ◽  
Entire Abdominal Cavity ◽  
Spontaneous Delivery

A case of prenatal ultrasound diagnosis of a rare congenital ovarian tumor is presented. By ultrasound examination at 36–37 weeks of gestation the intra-abdominal mass 66  47  74 mm occupying the entire abdominal cavity was discovered. At 38 weeks of pregnancy spontaneous delivery occurred with girl weight 2840 g. On the eighth day after birth the child has been successfully undergone surgery. Histological examination revealed congenital germ-cell tumor with structures of dysgerminoma and yolk sac tumor.

Memoirs: The Cytopasmic Inclusion of the Germ-Cells

1917 ◽  
Vol s2-62 (247) ◽  
pp. 407-463
Author(s):  
J. BRONTÉ GATENBY
Keyword(s):  
Germ Cell ◽  
Primordial Germ Cell ◽  
Growth Period ◽  
Pieris Brassicae ◽  
Constant Factor ◽  
Cytoplasmic Bodies ◽  
Female Germ Cell ◽  
Probable Nature ◽  
And Function ◽  
Definite Period

(1) In Smerinthus populi, Pieris brassicæ, and a number of other species of moths and butterflies the cytoplasmic bodies have been followed out. (2) The micromitosome lias been followed from the spermatocyte back into the secondary spermatogonium. It is very probably present in the primordial germ-cell. (3) The micromitosome has been definitely found in the female. (4) The micromitosome seems to divide in all divisions, and I consider that it is a constant factor in the spermatids of Smerinthus. (5) The probable nature and function of the micromitosome is discussed. (6) The mitochondria have been carefully examined in the male and female germ-cell in all stages except in the maturation division of the female and in fertilisation. (7) It has been shown that in early stages the cytoplasmic bodies of the female resemble those of the male. (8) There is a definite period, judged to be about the beginning of growth stage, when the subsequent fate of the mitochondria in the male becomes different from that of the female. (9) The remarkable formation of chromophobe and chromophile zones in the male mitochondrial body aud the use of these zones are described. (10) The formation of the macromitosome from the mitochondria is described. (11) The changes undergone by the macromitosome in sperm formation are followed out. (12) The presence of the acroblasts in the fairly early growth period of the spermatocyte is described. (13) The complicated evolutions of these bodies in division of the cells, their subsequent fate and' their probable nature are discussed. (14) The staining and fixing reactions of the cytoplasmic bodies are fully described. (15) A number of abnormalities have been described. (16) The centrosome has been shown to divide in the young spermatid, and one centrosome is probably lost, but definite evidence is not forthcoming.

scholarly journals Notch pathway regulates female germ cell meiosis progression and early oogenesis events in fetal mouse

Cell Cycle ◽  
2014 ◽  
Vol 13 (5) ◽  
pp. 782-791 ◽  
Author(s):  
Yan-Min Feng ◽  
Gui-Jin Liang ◽  
Bo Pan ◽  
XunSi Qin ◽  
Xi-Feng Zhang ◽  
...  
Keyword(s):  
Germ Cell ◽  
Notch Pathway ◽  
Fetal Mouse ◽  
Female Germ Cell
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