scholarly journals Effects of Growth Hormone and Pioglitazone in Viscerally Obese Adults with Impaired Glucose Tolerance: A Factorial Clinical Trial

2007 ◽  
Vol 2 (5) ◽  
pp. e21 ◽  
Author(s):  
Hamdee Attallah ◽  
Anne L Friedlander ◽  
Matilde Nino-Murcia ◽  
Andrew R Hoffman
Keyword(s):  
Clinical Trial ◽  
Growth Hormone ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Obese Adults

Metformin decreases plasma resistin concentrations in pediatric patients with impaired glucose tolerance: a placebo-controlled randomized clinical trial

Metabolism ◽  
2012 ◽  
Vol 61 (9) ◽  
pp. 1247-1255 ◽  
Author(s):  
Rita A. Gómez-Díaz ◽  
Juan O. Talavera ◽  
Elsy Canché Pool ◽  
Francisco Vianney Ortiz-Navarrete ◽  
Fortino Solórzano-Santos ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Randomized Clinical Trial ◽  
Pediatric Patients

scholarly journals Fortifying a meal with oyster mushroom powder beneficially affects postprandial glucagon-like peptide-1, non-esterified free fatty acids and hunger sensation in adults with impaired glucose tolerance: a double-blind randomized controlled crossover trial

2021 ◽  
Author(s):  
Lisa Dicks ◽  
Linda Jakobs ◽  
Miriam Sari ◽  
Reinhard Hambitzer ◽  
Norbert Ludwig ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Fatty Acids ◽  
Glucose Tolerance ◽  
Free Fatty Acids ◽  
Impaired Glucose Tolerance ◽  
Gastrointestinal Hormone ◽  
Randomized Controlled ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Hunger Sensation

Abstract Purpose Impaired glucose tolerance (IGT) is a pathophysiological condition characterized by insulin resistance with known metabolic consequences such as postprandial hyperglycemia and hypertriglyceridemia. We hypothesized that fortifying a meal with mushrooms rich in β-glucans may diminish glucose and triglyceride responses by improving postprandial gastrointestinal hormone release. Methods In a randomized controlled crossover study, 22 subjects with IGT ingested a meal either enriched with 20 g powder (8.1 g β-glucans) of oven-dried Pleurotus ostreatus (enriched meal, EN) or without enrichment (control meal, CON). Blood was collected before and repeatedly within 4 h after the meal to determine AUC of glucose (primary outcome), insulin, triglycerides, non-esterified free fatty acids (NEFAs), glucagon-like peptide-1 (GLP-1), gastric inhibitory polypeptide (GIP) and ghrelin. Appetite sensations (hunger, satiety, fullness, and desire to eat) were assessed before and after meal consumption by visual analog scales. Results Postprandial glucose, insulin, triglycerides, GIP and ghrelin concentrations as well as the corresponding AUCs did not differ between EN and CON. NEFAs-AUC was 14% lower (P = 0.026) and GLP-1-AUC 17% higher (P = 0.001) after EN compared to CON. Appetite ratings did not differ between treatments, except for hunger (AUC 22% lower after EN vs. CON; P = 0.031). Conclusion The observed immediate postprandial metabolic changes indicate that an easily manageable fortification of a single meal with powder from dried oyster mushrooms as β-glucan source may improve postprandial metabolism. If the effect is preserved long term, this measure can diminish the risk for further development of overweight/obesity and type 2 diabetes in subjects with IGT. Clinical trial registration German Clinical Trial Register on 09/08/2018; trial-ID: DRKS00015244.

scholarly journals Evaluation of a Standardized Extract fromMorus albaagainstα-Glucosidase Inhibitory Effect and Postprandial Antihyperglycemic in Patients with Impaired Glucose Tolerance: A Randomized Double-Blind Clinical Trial

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Seung Hwan Hwang ◽  
Hong Mei Li ◽  
Soon Sung Lim ◽  
Zhiqiang Wang ◽  
Jae-Seung Hong ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Blood Glucose ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Clinical Signs ◽  
Inhibitory Effect ◽  
Postprandial Hyperglycemia ◽  
Dependent Manner ◽  
Double Blind ◽  
Double Blind Clinical Trial

To evaluate the antihyperglycemic effect of a standardized extract of the leaves ofMorus alba(SEMA), the present study was designed to investigate theα-glucosidase inhibitory effect and acute single oral toxicity as well as evaluate blood glucose reduction in animals and in patients with impaired glucose tolerance in a randomized double-blind clinical trial. SEMA was found to inhibitα-glucosidase at a fourfold higher level than the positive control (acarbose), in a concentration-dependent manner. Moreover, blood glucose concentration was suppressed by SEMAin vivo. Clinical signs and weight changes were observed when conducting an evaluation of the acute toxicity of SEMA through a single-time administration, with clinical observation conducted more than once each day. After administration of the SEMA, observation was for 14 days; all of the animals did not die and did not show any abnormal symptoms. In addition, the inhibitory effects of rice coated with SEMA were evaluated in a group of impaired glucose tolerance patients on postprandial glucose and a group of normal persons, and results showed that SEMA had a clear inhibitory effect on postprandial hyperglycemia in both groups. Overall, SEMA showed excellent potential in the present study as a material for improving postprandial hyperglycemia.

Sign in / Sign up

Export Citation Format

Share Document