scholarly journals Efficacy of Antioxidant Treatment in Reducing Resistin Serum Levels: A Randomized Study

2007 ◽  
Vol 2 (5) ◽  
pp. e17 ◽  
Author(s):  
Simona Bo ◽  
Giovannino Ciccone ◽  
Marilena Durazzo ◽  
Roberto Gambino ◽  
Paola Massarenti ◽  
...  
Keyword(s):  
Randomized Study ◽  
Serum Levels ◽  
Antioxidant Treatment

scholarly journals Oxygen Persufflation in Liver Transplantation Results of a Randomized Controlled Trial

2019 ◽  
Vol 6 (2) ◽  
pp. 35 ◽  
Author(s):  
Anja Gallinat ◽  
Dieter Paul Hoyer ◽  
Georgios Sotiropoulos ◽  
Jürgen Treckmann ◽  
Tamas Benkoe ◽  
...  
Keyword(s):  
Patient Survival ◽  
Controlled Trial ◽  
Randomized Study ◽  
Serum Levels ◽  
Study Groups ◽  
Liver Preservation ◽  
History Of ◽  
Recipient Age ◽  
Effect Of Oxygen ◽  
Present Trial

Oxygen persufflation has shown experimentally to favorably influence hepatic energy dependent pathways and to improve survival after transplantation. The present trial evaluated oxygen persufflation as adjunct in clinical liver preservation. A total of n = 116 adult patients (age: 54 (23–68) years, M/F: 70/46), were enrolled in this prospective randomized study. Grafts were randomized to either oxygen persufflation for ≥2 h (O2) or mere cold storage (control). Only liver grafts from donors ≥55 years and/or marginal grafts after multiple rejections by other centers were included. Primary endpoint was peak-aspartate aminotransferase (AST) level until post-operative day 3. Standard parameters including graft- and patient survival were analyzed by uni- and multivariate analysis. Both study groups were comparable except for a longer ICU stay (4 versus 3 days) of the donors and a higher recipient age (57 versus 52 years) in the O2-group. Serum levels of TNF alpha were significantly reduced after oxygen persufflation (p < 0.05). Median peak-AST values did not differ between the groups (O2: 580 U/l, control: 699 U/l). Five year graft- and patient survival was similar. Subgroup analysis demonstrated a positive effect of oxygen persufflation concerning the development of early allograft dysfunction (EAD), in donors with a history of cardiopulmonary resuscitation and elevated ALT values, and concerning older or macrosteatotic livers. This study favors pre-implantation O2-persufflation in concrete subcategories of less than optimal liver grafts, for which oxygen persufflation can be considered a safe, cheap and easy applicable reconditioning method.

Analysis of cytokines in ECOG E4Z02: A phase III randomized study of l-carnitine supplementation for fatigue in patients with cancer

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 9635-9635
Author(s):  
T. A. Rich ◽  
M. J. Fisch ◽  
J. Manola ◽  
D. Cella ◽  
B. Ansari ◽  
...  
Keyword(s):  
Proinflammatory Cytokines ◽  
Randomized Study ◽  
Serum Levels ◽  
Pain Severity ◽  
Phase Iii ◽  
Carnitine Supplementation ◽  
Severe Fatigue ◽  
Cytokine Levels ◽  
Lower Pain ◽  
Ifn Γ

9635 Background: The purpose of the study was to investigate associations between fatigue, depression and pain and serum levels of proinflammatory cytokines among pts randomized to l-carnitine supplementation or placebo. Methods: 376 cancer pts with normal hemoglobin and fatigue assessed as moderate or severe were randomized to 4 wks of supplementation with oral carnitine (n=189) or placebo (n=187) 1000 mg bid. Serum levels of 10 inflammatory cytokines and growth factors were measured with Luminex bead ELISA at baseline and 4 wks for 98 pts. Wilcoxon rank sum tests were used to compare cytokine levels between arms and between pts with/without symptoms. Multivariable models of fatigue, depression and pain at 4 wks were examined, adjusting for treatment arm, baseline symptoms and baseline cytokine levels. Results: There were no statistically significant differences in cytokine levels between pts with or without severe fatigue, pain, or depression at baseline. Levels of IL-1rα were higher at baseline among pts randomized to placebo (p=0.01) and increased after 4 wks, while levels among pts randomized to l-carnitine declined (p <0.001). Levels of IFN-γ, TGF-α, IL-6, and TNF-α decreased more among pts randomized to placebo (p=0.008, p=0.006, p=0.01, and p=0.05, respectively). Pts with severe pain at 4 wks had greater declines in levels of EGF, IFN-γ, IL-1α, and IL-1rα than pts without (p=0.05, 0.05, 0.02 and 0.03, respectively). Reductions in IL-1α and TGF-α predicted lower pain severity at 4 wks (p=0.02 and p=0.04, respectively). Conclusions: Levels of proinflammatory cytokines or EGFR ligands failed to distinguish between patients with moderate vs. severe fatigue or levels of depression and pain (severe vs. not) prior to treatment intervention. Lower levels of IL-1α and TGF-α appear to be associated with improvement of pain severity but are not associated with treatment. Mechanisms for these findings require exploration. No significant financial relationships to disclose.

scholarly journals Comparison between the Effects of Early and Late Nourishing by Jejunal Feeding in Patients with Esophageal Cancer after Esophagectomy

2018 ◽  
Vol 6 (1) ◽  
pp. 30
Author(s):  
Samad Beheshti Rouy ◽  
Farzad Kakaei ◽  
Mehran Rahimi
Keyword(s):  
Esophageal Cancer ◽  
Conventional Method ◽  
Randomized Study ◽  
Serum Levels ◽  
Control Group ◽  
Case Group ◽  
Transfusion Rate ◽  
Icu Stay ◽  
Preoperative Serum ◽  
And Control

Background: Esophageal cancer has become one of the most common cancers in the last decade and multiple treatment methods can be prescribe based on its extent and grade. It has been proven that nutritional states are very important to tolerance surgery. Aim: The aim of this study was to evaluate the efficacyand safety of early (6 hours) starting of jejunal feeding comparing with late (72 hours) nourishing by jejunal feeding in patients with esophageal cancer after esophagectomy. Methods: In this prospective-randomized study, 50 patients undergoing esophagectomy for esophageal cancer were randomly divided into two groups. Then patients underwent surgery. In case group (n=25) nourishing by jejunostomy was started 6 hours after surgery and in control group (n=25) as a conventional method, nourishing by jejunostomy was started 72 hours after surgery. Results: There were no significantdifferences between two groups in term of age, type of tumor and grade of tumor. In case and control group; ICU stay time, hospitalization, transfusion rate, preoperative serum albumin level were 2.2±0.32 and 1.76±0.14 days, 9.28±0.56 and 9.12±0.14 days, 0.24±0.11 and 0.28±0.1 unites, 3.93±0.09 and 3.8±0.07, respectively. The albumin serum levels 6 hours and 72 after surgery in case and control group were 3.74±0.07 and 3.6±0.08, 3.66±0.08 and 3.54±0.07, respectively. Conclusion: Based on the results, the transfusion rate, ICU stay and hospitalization days in case group was lower than control group. But there were no significantdifferences between two groups. In general, it seems that early start of nutrition via jejunal tube in patients undergoing esophagectomy have no more complications comparing conventional method. Its benefits nee additional studies.

scholarly journals The Role of Angiopoietine-2 in the Diagnosis and Prognosis of Sepsis

2015 ◽  
Vol 1 (1) ◽  
pp. 18-23 ◽  
Author(s):  
Janos Szederjesi ◽  
Emoke Almasy ◽  
Alexandra Lazar ◽  
Adina HuȚanu ◽  
Anca Georgescu
Keyword(s):  
Intensive Care ◽  
Randomized Study ◽  
Serum Levels ◽  
Prognostic Scores ◽  
Positive Correlation ◽  
Diagnosis And Prognosis ◽  
Severity Scores ◽  
Diagnostic Role ◽  
Angiopoietin 2

Abstract Introduction: Angiopoietin-2 (ANG-2) is a new biomarker whose blood-serum values increase in sepsis and its expression is elevated in line with the severity of the degree of inflammation. The aim of this study was to identify the diagnostic role of ANG-2 in patients with non-surgical sepsis addmitted to an intensive care unit. Material and methods: This was a prospective randomized study including 74 patients admitted in the Clinic of Intensive Care of the County Clinical Emergency Hospital Tirgu Mure., divided into two groups: Group S: patients with sepsis (n=40, 54%) and Group C: control, without sepsis (n=34, 46%). ANG-2 levels were determined in both groups. Results: From the Group S, 14 patients (35%) had positive haemocultures. ANG-2 values varied between 1 and 43 ng/mL, with an average of 6.0 ng/mL in patients without sepsis and 10.38 ng/mL in patients with sepsis (p=0.021). A positive correlation between ANG-2 and SAPS II, SOFA and APACHE II severity scores was demonstrated, as was a positive correlation between serum levels of ANG-2 and procalcitonine. ANG-2 had a 5.71% specificity and 74.36% sensitivity for diagnosis of sepsis. Conclusions: ANG-2 serum levels were elevated in sepsis, being well correlated with PCT values and prognostic scores. ANG-2 should be considered as a useful biomarker for the diagnosis and the prognosis of this pathology.

scholarly journals Systemic effects after local injection of platelet-rich plasma: a prospective randomized study

2020 ◽  
Author(s):  
Shu-Jui Kuo ◽  
Wen-Yi Chou ◽  
Chieh-Cheng Hsu ◽  
Guo-Ping Chang-Chien ◽  
Su-Fan Lin ◽  
...  
Keyword(s):  
Growth Factor ◽  
Substance P ◽  
Sports Injuries ◽  
Platelet Rich Plasma ◽  
Randomized Study ◽  
Serum Levels ◽  
Saline Group ◽  
Prospective Randomized Study ◽  
Systemic Effects ◽  
Insulin Like Growth Factor

Abstract Background Platelet-rich plasma (PRP) is widely utilized in the treatment of sports injuries. However, potential systemic effects after localized PRP injection are unclear at present.Design: prospective randomized study Methods Twenty-four Taiwanese male athletes with tendinopathy were randomized into a PRP group (n = 13) or a saline group (n = 11).Results The results showed no significant differences in serum levels of growth hormone, insulin-like growth factor-1, insulin-like growth factor-binding protein 3, vascular endothelial growth factor, platelet-derived growth factor-BB, or serum substance P between the two groups at baseline, nor at 1, 2, or 7 days after intervention. However, a significant decrease in the serum substance P level 1 and 7 days after PRP injection was observed. Regarding urinary concentrations of metabolites of anabolic androgenic steroids (AAS), no between-group differences at baseline, nor at 1, 2, or 7 days after intervention, were observed. Conclusions Our study failed to observe significant surge of serum anabolic molecules and urinary excretion of anabolic AAS metabolites after PRP injection. Trial registration with ClinicalTrials.gov: NCT04456907

Randomized study of the effect of pentoxifylline or octreotide on serum levels of TNF-α and IL-6 after endoscopic retrograde cholangiopancreatography

2009 ◽  
Vol 21 (5) ◽  
pp. 529-533 ◽  
Author(s):  
Dimitrios Kapetanos ◽  
Dimitrios Christodoulou ◽  
Olga Chatzizisi ◽  
Dimitrios Sigounas ◽  
Konstantinos Vasiliou ◽  
...  
Keyword(s):  
Endoscopic Retrograde Cholangiopancreatography ◽  
Randomized Study ◽  
Serum Levels ◽  
Endoscopic Retrograde ◽  
Tnf Α
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