scholarly journals Synaptic plasticity onto inhibitory neurons as a mechanism for ocular dominance plasticity

2019 ◽  
Vol 15 (3) ◽  
pp. e1006834 ◽  
Author(s):  
Jacopo Bono ◽  
Claudia Clopath
Keyword(s):  
Synaptic Plasticity ◽  
Ocular Dominance ◽  
Inhibitory Neurons ◽  
Ocular Dominance Plasticity

scholarly journals Synaptic plasticity onto inhibitory neurons as a mechanism for ocular dominance plasticity

2018 ◽  
Author(s):  
Jacopo Bono ◽  
Claudia Clopath
Keyword(s):  
Synaptic Plasticity ◽  
Critical Period ◽  
Ocular Dominance ◽  
Visual Deprivation ◽  
Inhibitory Neurons ◽  
Cortical Circuits ◽  
Ocular Dominance Plasticity ◽  
Opening And Closing ◽  
Recent Experimental Work ◽  
Cortical Maturation

AbstractOcular dominance plasticity is a well-documented phenomenon allowing us to study properties of cortical maturation. Understanding this maturation might be an important step towards unravelling how cortical circuits function. However, it is still not fully understood which mechanisms are responsible for the opening and closing of the critical period for ocular dominance and how changes in cortical responsiveness arise after visual deprivation. In this article, we present a theory of ocular dominance plasticity. Following recent experimental work, we propose a framework where a reduction in inhibition is necessary for ocular dominance plasticity in both juvenile and adult animals. In this framework, two ingredients are crucial to observe ocular dominance shifts: a sufficient level of inhibition as well as excitatory-to-inhibitory synaptic plasticity. In our model, the former is responsible for the opening of the critical period, while the latter limits the plasticity in adult animals. Finally, we also provide a possible explanation for the variability in ocular dominance shifts observed in individual neurons and for the counter-intuitive shifts towards the closed eye.

scholarly journals Loss of P2Y12 Has Behavioral Effects in the Adult Mouse

2021 ◽  
Vol 22 (4) ◽  
pp. 1868
Author(s):  
Rebecca L. Lowery ◽  
Monique S. Mendes ◽  
Brandon T. Sanders ◽  
Allison J. Murphy ◽  
Brendan S. Whitelaw ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Ex Vivo ◽  
Purinergic Receptor ◽  
Ocular Dominance ◽  
Developmental Time ◽  
Brain Regions ◽  
Ocular Dominance Plasticity ◽  
Early Form ◽  
Adult Mice ◽  
Molecular Signals

While microglia have been established as critical mediators of synaptic plasticity, the molecular signals underlying this process are still being uncovered. Increasing evidence suggests that microglia utilize these signals in a temporally and regionally heterogeneous manner. Subsequently, it is necessary to understand the conditions under which different molecular signals are employed by microglia to mediate the physiological process of synaptic remodeling in development and adulthood. While the microglial purinergic receptor P2Y12 is required for ocular dominance plasticity, an adolescent form of experience-dependent plasticity, it remains unknown whether P2Y12 functions in other forms of plasticity at different developmental time points or in different brain regions. Using a combination of ex vivo characterization and behavioral testing, we examined how the loss of P2Y12 affects developmental processes and behavioral performance in adulthood in mice. We found P2Y12 was not required for an early form of plasticity in the developing visual thalamus and did not affect microglial migration into barrels in the developing somatosensory cortex. In adult mice, however, the loss of P2Y12 resulted in alterations in recognition and social memory, as well as anxiety-like behaviors, suggesting that while P2Y12 is not a universal regulator of synaptic plasticity, the loss of P2Y12 is sufficient to cause functional defects.

Regulation of ocular dominance plasticity by biogenic amines: An activity mapping using c-FOS immunohistochemistry in rat visual cortex

1998 ◽  
Vol 31 ◽  
pp. S181
Author(s):  
Kazuhiko Nakadate ◽  
Kazuyuki Imamura ◽  
Masayuki Kobayashi ◽  
Peter A. Kaub ◽  
Yasuyoshi Watanabe
Keyword(s):  
Visual Cortex ◽  
Biogenic Amines ◽  
Ocular Dominance ◽  
Ocular Dominance Plasticity

scholarly journals Homeostatic plasticity mechanisms in mouse V1

2017 ◽  
Vol 372 (1715) ◽  
pp. 20160504 ◽  
Author(s):  
Megumi Kaneko ◽  
Michael P. Stryker
Keyword(s):  
Visual Cortex ◽  
Primary Visual Cortex ◽  
Neuronal Activity ◽  
Dynamic Range ◽  
Ocular Dominance ◽  
Homeostatic Plasticity ◽  
Ocular Dominance Plasticity ◽  
The Brain

Mechanisms thought of as homeostatic must exist to maintain neuronal activity in the brain within the dynamic range in which neurons can signal. Several distinct mechanisms have been demonstrated experimentally. Three mechanisms that act to restore levels of activity in the primary visual cortex of mice after occlusion and restoration of vision in one eye, which give rise to the phenomenon of ocular dominance plasticity, are discussed. The existence of different mechanisms raises the issue of how these mechanisms operate together to converge on the same set points of activity. This article is part of the themed issue ‘Integrating Hebbian and homeostatic plasticity’.

scholarly journals Temporally Coherent Visual Stimuli Boost Ocular Dominance Plasticity

2013 ◽  
Vol 33 (29) ◽  
pp. 11774-11778 ◽  
Author(s):  
U. Matthies ◽  
J. Balog ◽  
K. Lehmann
Keyword(s):  
Ocular Dominance ◽  
Visual Stimuli ◽  
Ocular Dominance Plasticity

Ocular dominance plasticity: Molecular mechanisms revisited

2020 ◽  
Vol 528 (17) ◽  
pp. 3039-3074
Author(s):  
Takuji Kasamatsu ◽  
Kazuyuki Imamura
Keyword(s):  
Molecular Mechanisms ◽  
Ocular Dominance ◽  
Ocular Dominance Plasticity

scholarly journals Inhibition of Semaphorin3A Promotes Ocular Dominance Plasticity in the Adult Rat Visual Cortex

2019 ◽  
Vol 56 (9) ◽  
pp. 5987-5997 ◽  
Author(s):  
Elena Maria Boggio ◽  
Erich M. Ehlert ◽  
Leonardo Lupori ◽  
Elizabeth B. Moloney ◽  
Fred De Winter ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Ocular Dominance ◽  
Ocular Dominance Plasticity ◽  
Adult Rat
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