scholarly journals Cryo-EM structure of the human concentrative nucleoside transporter CNT3

PLoS Biology ◽  
2020 ◽  
Vol 18 (8) ◽  
pp. e3000790 ◽  
Author(s):  
Yanxia Zhou ◽  
Lianghuan Liao ◽  
Chen Wang ◽  
Jialu Li ◽  
Pengliang Chi ◽  
...  
Keyword(s):  
Nucleoside Transporter ◽  
Concentrative Nucleoside Transporter

scholarly journals Conserved Glutamate Residues Glu-343 and Glu-519 Provide Mechanistic Insights into Cation/Nucleoside Cotransport by Human Concentrative Nucleoside Transporter hCNT3

2009 ◽  
Vol 284 (25) ◽  
pp. 17266-17280 ◽  
Author(s):  
Melissa D. Slugoski ◽  
Kyla M. Smith ◽  
Amy M. L. Ng ◽  
Sylvia Y. M. Yao ◽  
Edward Karpinski ◽  
...  
Keyword(s):  
Nucleoside Transporter ◽  
Concentrative Nucleoside Transporter

Galectin‐4 interacts with the drug transporter human concentrative nucleoside transporter 3 to regulate its function

2015 ◽  
Vol 30 (2) ◽  
pp. 544-554 ◽  
Author(s):  
Paula Fernández‐Calotti ◽  
Olga Casulleras ◽  
María Antolin ◽  
Francisco Guarner ◽  
Marçal Pastor‐Anglada
Keyword(s):  
Nucleoside Transporter ◽  
Drug Transporter ◽  
Concentrative Nucleoside Transporter

A splice variant of the SLC28A3 gene encodes a novel human concentrative nucleoside transporter‐3 (hCNT3) protein localized in the endoplasmic reticulum

2008 ◽  
Vol 23 (1) ◽  
pp. 172-182 ◽  
Author(s):  
Ekaitz Errasti‐Murugarren ◽  
Miriam Molina‐Arcas ◽  
Fco Javier Casado ◽  
Marcal Pastor‐Anglada
Keyword(s):  
Endoplasmic Reticulum ◽  
Splice Variant ◽  
Nucleoside Transporter ◽  
Concentrative Nucleoside Transporter

The Human Concentrative Nucleoside Transporter-3 C602R Variant Shows Impaired Sorting to Lipid Rafts and Altered Specificity for Nucleoside-Derived Drugs

2010 ◽  
Vol 78 (2) ◽  
pp. 157-165 ◽  
Author(s):  
Ekaitz Errasti-Murugarren ◽  
Miriam Molina-Arcas ◽  
F. Javier Casado ◽  
Marçal Pastor-Anglada
Keyword(s):  
Lipid Rafts ◽  
Nucleoside Transporter ◽  
Concentrative Nucleoside Transporter

Hypouricemic Effects ofArmillaria melleaon Hyperuricemic Mice Regulated through OAT1 and CNT2

2018 ◽  
Vol 46 (03) ◽  
pp. 585-599 ◽  
Author(s):  
Tianqiao Yong ◽  
Shaodan Chen ◽  
Yizhen Xie ◽  
Diling Chen ◽  
Jiyan Su ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Glucose Transporter ◽  
Organic Anion ◽  
Inhibitory Effect ◽  
Organic Anion Transporter ◽  
Nucleoside Transporter ◽  
Inhibitory Effects ◽  
Concentrative Nucleoside Transporter ◽  
Anion Transporter ◽  
Glucose Transporter 9

Ethanol and water extracts of Armillaria mellea were prepared by directly soaking A. mellea in ethanol (AME) at 65[Formula: see text]C, followed by decocting the remains in water (AMW) at 85[Formula: see text]C. Significantly, AME and AMW at 30, 60 and 120[Formula: see text]mg/kg exhibited excellent hypouricemic actions, causing remarkable declines from hyperuricemic control (351[Formula: see text][Formula: see text]mol/L, [Formula: see text]) to 136, 130 and 115[Formula: see text][Formula: see text]mol/L and 250, 188 and 152[Formula: see text][Formula: see text]mol/L in serum uric acid, correspondingly. In contrast to the evident renal toxicity of allopurinol, these preparations showed little impacts. Moreover, they showed some inhibitory effect on XOD (xanthine oxidase) activity. Compared with hyperuricemic control, protein expressions of OAT1 (organic anion transporter 1) were significantly elevated in AME- and AMW-treated mice. The levels of GLUT9 (glucose transporter 9) expression were significantly decreased by AMW. CNT2 (concentrative nucleoside transporter 2), a key target for purine absorption in gastrointestinal tract was involved in this study, and was verified for its innovative role. Both AME and AMW down-regulated CNT2 proteins in the gastrointestinal tract in hyperuricemic mice. As they exhibited considerable inhibitory effects on XOD, we selected XOD as the target for virtual screening by using molecular docking, and four compounds were hit with high ranks. From the analysis, we concluded that hydrogen bond, Pi–Pi and Pi-sigma interactions might play important roles for their orientations and locations in XOD inhibition.

scholarly journals Conserved Glutamate Residues Are Critically Involved in Na+/Nucleoside Cotransport by Human Concentrative Nucleoside Transporter 1 (hCNT1)

2007 ◽  
Vol 282 (42) ◽  
pp. 30607-30617 ◽  
Author(s):  
Sylvia Y. M. Yao ◽  
Amy M. L. Ng ◽  
Melissa D. Slugoski ◽  
Kyla M. Smith ◽  
Ras Mulinta ◽  
...  
Keyword(s):  
Nucleoside Transporter ◽  
Concentrative Nucleoside Transporter
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