scholarly journals Heterochromatin delays CRISPR-Cas9 mutagenesis but does not influence the outcome of mutagenic DNA repair

PLoS Biology ◽  
2018 ◽  
Vol 16 (12) ◽  
pp. e2005595 ◽  
Author(s):  
Eirini M. Kallimasioti-Pazi ◽  
Keerthi Thelakkad Chathoth ◽  
Gillian C. Taylor ◽  
Alison Meynert ◽  
Tracy Ballinger ◽  
...  
Keyword(s):  
Dna Repair ◽  
Mutagenic Dna Repair

scholarly journals 53BP1 Mediates Productive and Mutagenic DNA Repair through Distinct Phosphoprotein Interactions

Cell ◽  
2013 ◽  
Vol 153 (6) ◽  
pp. 1266-1280 ◽  
Author(s):  
Elsa Callen ◽  
Michela Di Virgilio ◽  
Michael J. Kruhlak ◽  
Maria Nieto-Soler ◽  
Nancy Wong ◽  
...  
Keyword(s):  
Dna Repair ◽  
Mutagenic Dna Repair

scholarly journals Long-Term Effect of Mutagenic DNA Repair on Accumulation of Mutations in Pseudomonas syringae B86-17

2004 ◽  
Vol 186 (22) ◽  
pp. 7807-7810 ◽  
Author(s):  
Shouan Zhang ◽  
George W. Sundin
Keyword(s):  
Growth Rate ◽  
Dna Repair ◽  
Pseudomonas Syringae ◽  
Minimal Medium ◽  
Term Effect ◽  
Deficient Mutant ◽  
Single Colony ◽  
Long Term Effect ◽  
Mutagenic Dna Repair

ABSTRACT Forty replicate lineages of Pseudomonas syringae B86-17 cells expressing the rulAB mutagenic DNA repair (MDR) determinant or the rulB::Km MDR-deficient mutant GWS242 were passaged through single-cell bottlenecks (60 cycles), with a UV radiation (UVR) exposure given to half of the lineages at the beginning of each cycle. After every 10th bottleneck cycle, single-colony isolates from all 80 lineages were subjected to 39 phenotypic screens, with newly arising mutations detected in 60 and 0% of UVR-exposed or non-UVR-exposed B86-17 lineages, respectively, by the 60th cycle. Cellular fitness, measured as growth rate in a minimal medium, of UVR-exposed lineages of both B86-17 and GWS242 after 60 cycles was not significantly different from that of the ancestral strains. Although UVR exposure and MDR activity increased the occurrence of mutations in cells, a significant reduction in overall fitness was not observed.

Functional complementation between chromosomal and plasmid mutagenic DNA repair genes in bacteria

1991 ◽  
Vol 229 (3) ◽  
pp. 428-436 ◽  
Author(s):  
Steven G. Sedgwick ◽  
David Lodwick ◽  
Noel Doyle ◽  
Helen Crowne ◽  
Peter Strike
Keyword(s):  
Dna Repair ◽  
Functional Complementation ◽  
Dna Repair Genes ◽  
Mutagenic Dna Repair ◽  
Repair Genes

scholarly journals Mutagenic DNA repair in enterobacteria.

1991 ◽  
Vol 173 (18) ◽  
pp. 5604-5611 ◽  
Author(s):  
S G Sedgwick ◽  
C Ho ◽  
R Woodgate
Keyword(s):  
Dna Repair ◽  
Mutagenic Dna Repair
Sign in / Sign up

Export Citation Format

Share Document