scholarly journals Mesenchymal Transition and Dissemination of Cancer Cells Is Driven by Myeloid-Derived Suppressor Cells Infiltrating the Primary Tumor

PLoS Biology ◽  
2011 ◽  
Vol 9 (9) ◽  
pp. e1001162 ◽  
Author(s):  
Benjamin Toh ◽  
Xiaojie Wang ◽  
Jo Keeble ◽  
Wen Jing Sim ◽  
Karen Khoo ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Primary Tumor ◽  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells ◽  
Mesenchymal Transition

scholarly journals Targeting Myeloid-Derived Suppressor Cells Derived From Surgical Stress: The Key to Prevent Post-surgical Metastasis

2021 ◽  
Vol 8 ◽  
Author(s):  
Sha Zhu ◽  
Yunuo Zhao ◽  
Yuxin Quan ◽  
Xuelei Ma
Keyword(s):  
Cancer Patients ◽  
Primary Tumor ◽  
Acute Stress ◽  
Surgical Stress ◽  
Tumor Development ◽  
Suppressor Cells ◽  
Radical Resection ◽  
Myeloid Derived Suppressor Cells ◽  
Term Survival ◽  
Perioperative Phase

Myeloid-derived suppressor cells (MDSCs) are known to play an essential part in tumor progression under chronic stress settings through their manipulation of adaptive and innate immune systems. Previous researches mainly focus on MDSC's role in the chronic tumor immune environment. In addition, surgery can also serve as a form of acute stress within the patient's internal environment. Nevertheless, the part that MDSCs play in post-surgical tumor development has not gained enough attention yet. Although surgery is known to be an effective definite treatment for most localized solid tumors, there are still plenty of cancer patients who experience recurrence or metastasis after radical resection of the primary tumor. It is believed that surgery has the paradoxical capability to enhance tumor growth. Many possible mechanisms exist for explaining post-surgical metastasis. We hypothesize that surgical resection of the primary tumor can also facilitate the expansion of MDSCs and their pro-tumor role since these surgery-induced MDSCs can prepare the pre-metastatic niche (the “soil”) and at the same time interact with circulating tumor cells (the “seeds”). This vicious, reciprocal mechanism is a crucial point in the emergence of post-surgical metastasis. According to our hypothesis, MDSCs can be the precise target to prevent cancer patients from post-surgical recurrence and metastasis during the perioperative phase to break the wretched cycle and provide better long-term survival for these patients. Future studies are needed to validate this hypothesis.

scholarly journals Doxorubicin resistant cancer cells activate myeloid-derived suppressor cells by releasing PGE2

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Yuan Rong ◽  
Chun-Hui Yuan ◽  
Zhen Qu ◽  
Hu Zhou ◽  
Qing Guan ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells

scholarly journals Granulocytic Myeloid‐Derived Suppressor Cells Promote the Stemness of Colorectal Cancer Cells through Exosomal S100A9

2019 ◽  
Vol 6 (18) ◽  
pp. 1901278 ◽  
Author(s):  
Yungang Wang ◽  
Kai Yin ◽  
Jie Tian ◽  
Xueli Xia ◽  
Jie Ma ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells ◽  
Colorectal Cancer Cells

scholarly journals Myeloid-Derived Suppressor Cells Enhance Stemness of Cancer Cells by Inducing MicroRNA101 and Suppressing the Corepressor CtBP2

Immunity ◽  
2013 ◽  
Vol 39 (3) ◽  
pp. 611-621 ◽  
Author(s):  
Tracy X. Cui ◽  
Ilona Kryczek ◽  
Lili Zhao ◽  
Ende Zhao ◽  
Rork Kuick ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells

Primary Tumor Resection Decreased the Number of Myeloid Derived Suppressor Cells and Increased CD4 and CD8 Cells

2012 ◽  
Vol 172 (2) ◽  
pp. 346
Author(s):  
O.M. Rashid ◽  
M. Nagahashi ◽  
S. Ramachandran ◽  
L. Graham ◽  
H.D. Bear ◽  
...  
Keyword(s):  
Primary Tumor ◽  
Tumor Resection ◽  
Suppressor Cells ◽  
Primary Tumor Resection ◽  
Myeloid Derived Suppressor Cells ◽  
Cd8 Cells
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