scholarly journals Insulin Signaling and Dietary Restriction Differentially Influence the Decline of Learning and Memory with Age

PLoS Biology ◽  
2010 ◽  
Vol 8 (5) ◽  
pp. e1000372 ◽  
Author(s):  
Amanda L. Kauffman ◽  
Jasmine M. Ashraf ◽  
M. Ryan Corces-Zimmerman ◽  
Jessica N. Landis ◽  
Coleen T. Murphy
Keyword(s):  
Learning And Memory ◽  
Dietary Restriction ◽  
Insulin Signaling

Pioglitazone and exenatide enhance cognition and downregulate hippocampal beta amyloid oligomer and microglia expression in insulin-resistant rats

2016 ◽  
Vol 94 (8) ◽  
pp. 819-828 ◽  
Author(s):  
Enas S. Gad ◽  
Sawsan A. Zaitone ◽  
Yasser M. Moustafa
Keyword(s):  
Insulin Resistance ◽  
Learning And Memory ◽  
Insulin Signaling ◽  
Beta Amyloid ◽  
Male Rats ◽  
Insulin Resistant ◽  
Ppar Γ ◽  
Glucagon Like Peptide 1 ◽  
Underlying Mechanisms ◽  
Amyloid Oligomer

Insulin resistance is known to be a risk factor for cognitive impairment, most likely linked to insulin signaling, microglia overactivation, and beta amyloid (Aβ) deposition in the brain. Exenatide, a long lasting glucagon-like peptide-1 (GLP-1) analogue, enhances insulin signaling and shows neuroprotective properties. Pioglitazone, a peroxisome proliferated-activated receptor-γ (PPAR-γ) agonist, was previously reported to enhance cognition through its effect on Aβ accumulation and clearance. In the present study, insulin resistance was induced in male rats by drinking fructose for 12 weeks. The effect of monotherapy with pioglitazone (10 mg·kg−1) and exenatide or their combination on memory dysfunction was determined and some of the probable underlying mechanisms were studied. The current results confirmed that (1) feeding male rats with fructose syrup for 12 weeks resulted in a decline of learning and memory registered in eight-arm radial maze test; (2) treatment with pioglitazone or exenatide enhanced cognition, reduced hippocampal neurodegeneration, and reduced hippocampal microglia expression and beta amyloid oligomer deposition in a manner that is equal to monotherapies. These results may give promise for the use of pioglitazone or exenatide for ameliorating the learning and memory deficits associated with insulin resistance in clinical setting.

Sex differences in learning and memory following short‐term dietary restriction in the rat

2014 ◽  
Vol 36 (1) ◽  
pp. 74-80 ◽  
Author(s):  
Ebrahim Rajab ◽  
Batool Alqanbar ◽  
Mohammed J. Naiser ◽  
Habib A. Abdulla ◽  
Monaf M. Al‐Momen ◽  
...  
Keyword(s):  
Sex Differences ◽  
Learning And Memory ◽  
Dietary Restriction ◽  
Short Term

Insulin secretion and signaling in response to dietary restriction and subsequent re-alimentation in cattle

2015 ◽  
Vol 47 (8) ◽  
pp. 344-354 ◽  
Author(s):  
Kate Keogh ◽  
David A. Kenny ◽  
Alan K. Kelly ◽  
Sinéad M. Waters
Keyword(s):  
Skeletal Muscle ◽  
Signaling Pathway ◽  
Dietary Restriction ◽  
Insulin Signaling ◽  
Compensatory Growth ◽  
Insulin Response ◽  
Insulin Signaling Pathway ◽  
Longissimus Dorsi ◽  
Period 2 ◽  
Ad Libitum

The objectives of this study were to examine systemic insulin response to a glucose tolerance test (GTT) and transcript abundance of genes of the insulin signaling pathway in skeletal muscle, during both dietary restriction and re-alimentation-induced compensatory growth. Holstein Friesian bulls were blocked to one of two groups: 1) restricted feed allowance for 125 days ( period 1) (RES, n = 15) followed by ad libitum feeding for 55 days ( period 2) or 2) ad libitum access to feed throughout (periods 1 and 2) (ADLIB, n = 15). On days 90 and 36 of periods 1 and 2, respectively, a GTT was performed. M. longissimus dorsi biopsies were harvested from all bulls on days 120 and 15 of periods 1 and 2, respectively, and RNA-Seq analysis was performed. RES displayed a lower growth rate during period 1 (RES: 0.6 kg/day, ADLIB: 1.9 kg/day; P < 0.001), subsequently gaining more during re-alimentation (RES: 2.5 kg/day, ADLIB: 1.4 kg/day; P < 0.001). Systemic insulin response to glucose administration was lower in RES in period 1 ( P < 0.001) with no difference observed during period 2. The insulin signaling pathway in M. longissimus dorsi was enriched ( P < 0.05) in response to dietary restriction but not during re-alimentation ( P > 0.05). Genes differentially expressed in the insulin signaling pathway suggested a greater sensitivity to insulin in skeletal muscle, with pleiotropic effects of insulin signaling interrupted during dietary restriction. Collectively, these results indicate increased sensitivity to glucose clearance and skeletal muscle insulin signaling during dietary restriction; however, no overall role for insulin was apparent in expressing compensatory growth.

Xanthoceraside attenuates learning and memory deficits via improving insulin signaling in STZ-induced AD rats

2013 ◽  
Vol 543 ◽  
pp. 115-120 ◽  
Author(s):  
Peng Liu ◽  
Libo Zou ◽  
Qing Jiao ◽  
Tianyan Chi ◽  
Xuefei Ji ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Insulin Signaling ◽  
Memory Deficits ◽  
Learning And Memory Deficits

Continuous VA deficiency during postnatal development decreases rat learning and memory function via excitatory Ca2+neuron

2010 ◽  
Vol 34 (8) ◽  
pp. S18-S18
Author(s):  
Wei Jiang ◽  
Enyi Wen ◽  
Min Gong ◽  
Yang Bi ◽  
Xiaojuan Zhang ◽  
...  
Keyword(s):  
Postnatal Development ◽  
Learning And Memory ◽  
Memory Function
Sign in / Sign up

Export Citation Format

Share Document