scholarly journals SUMO-Specific Protease 2 Is Essential for Modulating p53-Mdm2 in Development of Trophoblast Stem Cell Niches and Lineages

PLoS Biology ◽  
2008 ◽  
Vol 6 (12) ◽  
pp. e310 ◽  
Author(s):  
Shang-Yi Chiu ◽  
Naoya Asai ◽  
Frank Costantini ◽  
Wei Hsu
Keyword(s):  
Stem Cell ◽  
Trophoblast Stem ◽  
Specific Protease ◽  
Trophoblast Stem Cell ◽  
Stem Cell Niches

scholarly journals ECM-Dependent HIF Induction Directs Trophoblast Stem Cell Fate via LIMK1-Mediated Cytoskeletal Rearrangement

PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e56949 ◽  
Author(s):  
Hwa J. Choi ◽  
Timothy A. Sanders ◽  
Kathryn V. Tormos ◽  
Kurosh Ameri ◽  
Justin D. Tsai ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Stem Cell Fate ◽  
Cytoskeletal Rearrangement ◽  
Trophoblast Stem ◽  
Trophoblast Stem Cell

scholarly journals Connexin31.1 (Gjb5) Deficiency Blocks Trophoblast Stem Cell Differentiation and Delays Placental Development

2014 ◽  
Vol 23 (21) ◽  
pp. 2649-2660 ◽  
Author(s):  
Mark Kibschull ◽  
Keith Colaco ◽  
Elzbieta Matysiak-Zablocki ◽  
Elke Winterhager ◽  
Stephen J. Lye
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Stem Cell Differentiation ◽  
Placental Development ◽  
Trophoblast Stem ◽  
Trophoblast Stem Cell

Modulation of trophoblast stem cell and giant cell phenotypes: analyses using the Rcho-1 cell model

2005 ◽  
Vol 73 (9-10) ◽  
pp. 452-462 ◽  
Author(s):  
Namita Sahgal ◽  
Lindsey N. Canham ◽  
Toshihiro Konno ◽  
Michael W. Wolfe ◽  
Michael J. Soares
Keyword(s):  
Stem Cell ◽  
Giant Cell ◽  
Cell Model ◽  
Trophoblast Stem ◽  
Trophoblast Stem Cell ◽  
Cell Phenotypes

scholarly journals Establishment of trophoblast stem cell lines from somatic cell nuclear-transferred embryos

2009 ◽  
Vol 106 (38) ◽  
pp. 16293-16297 ◽  
Author(s):  
M. Oda ◽  
S. Tanaka ◽  
Y. Yamazaki ◽  
H. Ohta ◽  
M. Iwatani ◽  
...  
Keyword(s):  
Stem Cell ◽  
Somatic Cell ◽  
Cell Lines ◽  
Trophoblast Stem ◽  
Trophoblast Stem Cell ◽  
Stem Cell Lines

Impact of Galectin-1 on Trophoblast Stem Cell Differentiation and Invasion in In Vitro Implantation Model

2017 ◽  
Vol 25 (5) ◽  
pp. 700-711 ◽  
Author(s):  
Minyue Tang ◽  
Jiali You ◽  
Wei Wang ◽  
Yongchao Lu ◽  
Xiaoling Hu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Stem Cell Differentiation ◽  
Trophoblast Stem ◽  
Trophoblast Stem Cell ◽  
Implantation Model

scholarly journals Ets2 is required for trophoblast stem cell self-renewal

2007 ◽  
Vol 312 (1) ◽  
pp. 284-299 ◽  
Author(s):  
Fang Wen ◽  
John A. Tynan ◽  
Grace Cecena ◽  
Roy Williams ◽  
Jorge Múnera ◽  
...  
Keyword(s):  
Stem Cell ◽  
Self Renewal ◽  
Trophoblast Stem ◽  
Trophoblast Stem Cell

scholarly journals MAP3K4 Controls the Chromatin Modifier HDAC6 during Trophoblast Stem Cell Epithelial-to-Mesenchymal Transition

Cell Reports ◽  
2017 ◽  
Vol 18 (10) ◽  
pp. 2387-2400 ◽  
Author(s):  
Robert J. Mobley ◽  
Deepthi Raghu ◽  
Lauren D. Duke ◽  
Kayley Abell-Hart ◽  
Jon S. Zawistowski ◽  
...  
Keyword(s):  
Stem Cell ◽  
Epithelial To Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Trophoblast Stem ◽  
Trophoblast Stem Cell ◽  
Chromatin Modifier

scholarly journals Single cell trajectory modeling identifies a primitive trophoblast state defined by BCAM enrichment

2021 ◽  
Author(s):  
Matthew Shannon ◽  
Jennet Baltayeva ◽  
Barbara Castellana ◽  
Jasmin Wachter ◽  
Samantha Yoon ◽  
...  
Keyword(s):  
Stem Cell ◽  
Single Cell ◽  
Gene Networks ◽  
First Trimester ◽  
Human Trophoblast ◽  
Stem Cell Maintenance ◽  
Trophoblast Stem ◽  
Intermediate Column ◽  
Trophoblast Stem Cell ◽  
And Function

The establishment and function of the human placenta is dependent on specialized cells called trophoblasts. Progenitor cytotrophoblasts (CTBs) differentiate along one of two cellular trajectories: the villous or extravillous pathways. CTBs committed to the villous pathway fuse with neighboring CTBs forming the outer multinucleated syncytiotrophoblast layer (SCT), while CTBs committed to the extravillous pathway develop into multi-layered cell columns that anchor the placenta to uterine tissue. At distal column sites, column CTBs differentiate into invasive extravillous trophoblasts (EVT) that facilitate uterine remodeling of spiral arteries and modulate the maternal immune response to fetal antigen. Unfortunately, little is known about the cellular and molecular processes controlling human trophoblast stem cell maintenance and differentiation into these critical trophoblast sub-lineages. To address this, our laboratory established a single cell RNA sequencing (scRNA-seq) dataset from first trimester placentas to identify molecular programs and cell states important in trophoblast progenitor establishment, renewal, and differentiation. Using this dataset, eight distinct trophoblast states were identified, representing progenitor cytotrophoblasts, intermediate column CTBs, syncytiotrophoblast progenitors, and terminally differentiated EVT. Lineage trajectory analysis identified a CTB origin that was reproduced in human trophoblast stem cell organoids. Heightened expression of basal cell adhesion molecule (BCAM) defined this primitive state, where CTBs selected for high levels of surface BCAM expression generated larger clonally-derived organoids than did CTB counterparts expressing lower levels of BCAM. Together, this work resolves complex gene networks within human trophoblast progenitor cells, and identifies BCAM as marker that defines an up-stream progenitor origin.

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