scholarly journals OSM-11 Facilitates LIN-12 Notch Signaling during Caenorhabditis elegans Vulval Development

PLoS Biology ◽  
2008 ◽  
Vol 6 (8) ◽  
pp. e196 ◽  
Author(s):  
Hidetoshi Komatsu ◽  
Michael Y Chao ◽  
Jonah Larkins-Ford ◽  
Mark E Corkins ◽  
Gerard A Somers ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Notch Signaling ◽  
Vulval Development

scholarly journals Transcriptional network underlying Caenorhabditis elegans vulval development

2005 ◽  
Vol 102 (14) ◽  
pp. 4972-4977 ◽  
Author(s):  
T. Inoue ◽  
M. Wang ◽  
T. O. Ririe ◽  
J. S. Fernandes ◽  
P. W. Sternberg
Keyword(s):  
Caenorhabditis Elegans ◽  
Transcriptional Network ◽  
Vulval Development

scholarly journals Computational insights into Caenorhabditis elegans vulval development

2005 ◽  
Vol 102 (6) ◽  
pp. 1951-1956 ◽  
Author(s):  
J. Fisher ◽  
N. Piterman ◽  
E. J. A. Hubbard ◽  
M. J. Stern ◽  
D. Harel
Keyword(s):  
Caenorhabditis Elegans ◽  
Vulval Development

scholarly journals A conserved tetraspanin subfamily promotes Notch signaling in Caenorhabditis elegans and in human cells

2010 ◽  
Vol 107 (13) ◽  
pp. 5907-5912 ◽  
Author(s):  
C. D. Dunn ◽  
M. L. Sulis ◽  
A. A. Ferrando ◽  
I. Greenwald
Keyword(s):  
Caenorhabditis Elegans ◽  
Notch Signaling ◽  
Human Cells

The terminal differentiation factor LIN-29 is required for proper vulval morphogenesis and egg laying in Caenorhabditis elegans

Development ◽  
1997 ◽  
Vol 124 (21) ◽  
pp. 4333-4342 ◽  
Author(s):  
J.C. Bettinger ◽  
S. Euling ◽  
A.E. Rougvie
Keyword(s):  
Caenorhabditis Elegans ◽  
Terminal Differentiation ◽  
Egg Laying ◽  
Small Subset ◽  
Wild Type ◽  
Vulval Development ◽  
Genetic Mosaics ◽  
Hypodermal Cell ◽  
Heterochronic Gene ◽  
Final Molt

Caenorhabditis elegans vulval development culminates during exit from the L4-to-adult molt with the formation of an opening through the adult hypodermis and cuticle that is used for egg laying and mating. Vulva formation requires the heterochronic gene lin-29, which triggers hypodermal cell terminal differentiation during the final molt. lin-29 mutants are unable to lay eggs or mate because no vulval opening forms; instead, a protrusion forms at the site of the vulva. We demonstrate through analysis of genetic mosaics that lin-29 is absolutely required in a small subset of lateral hypodermal seam cells, adjacent to the vulva, for wild-type vulva formation and egg laying. However, lin-29 function is not strictly limited to the lateral hypodermis. First, LIN-29 accumulates in many non-hypodermal cells with known roles in vulva formation or egg laying. Second, animals homozygous for one lin-29 allele, ga94, have the vulval defect and cannot lay eggs, despite having a terminally differentiated adult lateral hypodermis. Finally, vulval morphogenesis and egg laying requires lin-29 activity within the EMS lineage, a lineage that does not generate hypodermal cells.

scholarly journals Cell fate-specific regulation of EGF receptor trafficking during Caenorhabditis elegans vulval development

2006 ◽  
Vol 25 (11) ◽  
pp. 2347-2357 ◽  
Author(s):  
Attila Stetak ◽  
Erika Fröhli Hoier ◽  
Assunta Croce ◽  
Giuseppe Cassata ◽  
Pier Paolo Di Fiore ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Cell Fate ◽  
Egf Receptor ◽  
Receptor Trafficking ◽  
Vulval Development ◽  
Specific Regulation

scholarly journals Transcriptional control of Notch signaling by a HOX and a PBX/EXD protein during vulval development in C. elegans

2007 ◽  
Vol 302 (2) ◽  
pp. 661-669 ◽  
Author(s):  
Krisztina Takács-Vellai ◽  
Tibor Vellai ◽  
Estella B. Chen ◽  
Yue Zhang ◽  
Frédéric Guerry ◽  
...  
Keyword(s):  
Notch Signaling ◽  
Transcriptional Control ◽  
Vulval Development ◽  
C Elegans
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