scholarly journals Protein Aggregation and Protein Instability Govern Familial Amyotrophic Lateral Sclerosis Patient Survival

PLoS Biology ◽  
2008 ◽  
Vol 6 (7) ◽  
pp. e170 ◽  
Author(s):  
Qi Wang ◽  
Joshua L Johnson ◽  
Nathalie Y.R Agar ◽  
Jeffrey N Agar
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Protein Aggregation ◽  
Patient Survival ◽  
Amyotrophic Lateral Sclerosis Patient ◽  
Familial Amyotrophic Lateral Sclerosis ◽  
Protein Instability ◽  
Lateral Sclerosis

scholarly journals Novel TBK1 truncating mutation in a familial amyotrophic lateral sclerosis patient of Chinese origin

2015 ◽  
Vol 36 (12) ◽  
pp. 3334.e1-3334.e5 ◽  
Author(s):  
Kelly L. Williams ◽  
Emily P. McCann ◽  
Jennifer A. Fifita ◽  
Katharine Zhang ◽  
Emma L. Duncan ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Amyotrophic Lateral Sclerosis Patient ◽  
Familial Amyotrophic Lateral Sclerosis ◽  
Truncating Mutation ◽  
Chinese Origin ◽  
Lateral Sclerosis

scholarly journals VAPB and C9orf72 mutations in 1 familial amyotrophic lateral sclerosis patient

2012 ◽  
Vol 33 (12) ◽  
pp. 2950.e1-2950.e4 ◽  
Author(s):  
Marka van Blitterswijk ◽  
Michael A. van Es ◽  
Max Koppers ◽  
Wouter van Rheenen ◽  
Jelena Medic ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Amyotrophic Lateral Sclerosis Patient ◽  
Familial Amyotrophic Lateral Sclerosis ◽  
Lateral Sclerosis

scholarly journals Mitophagy Modulation, a New Player in the Race against ALS

2021 ◽  
Vol 22 (2) ◽  
pp. 740
Author(s):  
Enrique Madruga ◽  
Inés Maestro ◽  
Ana Martínez
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Protein Aggregation ◽  
Neurodegenerative Disease ◽  
Effective Treatment ◽  
Unknown Etiology ◽  
Drug Candidates ◽  
Relevant Evidence ◽  
Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disease that usually results in respiratory paralysis in an interval of 2 to 4 years. ALS shows a multifactorial pathogenesis with an unknown etiology, and currently lacks an effective treatment. The vast majority of patients exhibit protein aggregation and a dysfunctional mitochondrial accumulation in their motoneurons. As a result, autophagy and mitophagy modulators may be interesting drug candidates that mitigate key pathological hallmarks of the disease. This work reviews the most relevant evidence that correlate mitophagy defects and ALS, and discusses the possibility of considering mitophagy as an interesting target in the search for an effective treatment for ALS.

Sign in / Sign up

Export Citation Format

Share Document