scholarly journals The Hand That Protects: Structural Insights into a Porphyrin-Binding Protein

PLoS Biology ◽  
2005 ◽  
Vol 3 (5) ◽  
pp. e167
Keyword(s):  
Binding Protein ◽  
Structural Insights

scholarly journals Structural insights into the methyl donor recognition model of a novel membrane-binding protein UbiG

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Yuwei Zhu ◽  
Xuguang Jiang ◽  
Chongyuan Wang ◽  
Yang Liu ◽  
Xiaojiao Fan ◽  
...  
Keyword(s):  
Binding Protein ◽  
Membrane Binding ◽  
Recognition Model ◽  
Methyl Donor ◽  
Structural Insights

scholarly journals The structures of penicillin-binding protein 4 (PBP4) and PBP5 fromEnterococciprovide structural insights into β-lactam resistance

2018 ◽  
Vol 293 (48) ◽  
pp. 18574-18584 ◽  
Author(s):  
Thomas M. Moon ◽  
Éverton D. D'Andréa ◽  
Christopher W. Lee ◽  
Alexei Soares ◽  
Jean Jakoncic ◽  
...  
Keyword(s):  
Binding Protein ◽  
Penicillin Binding Protein ◽  
Structural Insights

scholarly journals Structural Insights into Ceftobiprole Inhibition of Pseudomonas aeruginosa Penicillin-Binding Protein 3

2020 ◽  
Vol 64 (5) ◽  
Author(s):  
Vijay Kumar ◽  
Christie Tang ◽  
Christopher R. Bethel ◽  
Krisztina M. Papp-Wallace ◽  
Jacob Wyatt ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Binding Sites ◽  
Binding Protein ◽  
Covalent Bond ◽  
Penicillin Binding Protein ◽  
Content Type ◽  
Cephalosporin Antibiotic ◽  
Structural Insights ◽  
Fine Tune ◽  
Advanced Generation

ABSTRACT Ceftobiprole is an advanced-generation broad-spectrum cephalosporin antibiotic with potent and rapid bactericidal activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus, as well as susceptible Gram-negative pathogens, including Pseudomonas sp. pathogens. In the case of Pseudomonas aeruginosa, ceftobiprole acts by inhibiting P. aeruginosa penicillin-binding protein 3 (PBP3). Structural studies were pursued to elucidate the molecular details of this PBP inhibition. The crystal structure of the His-tagged PBP3-ceftobiprole complex revealed a covalent bond between the ligand and the catalytic residue S294. Ceftobiprole binding leads to large active site changes near binding sites for the pyrrolidinone and pyrrolidine rings. The S528 to L536 region adopts a conformation previously not observed in PBP3, including partial unwinding of the α11 helix. These molecular insights can lead to a deeper understanding of β-lactam-PBP interactions that result in major changes in protein structure, as well as suggesting how to fine-tune current inhibitors and to develop novel inhibitors of this PBP.

Structural insights into the assembly of C4b-binding protein via its oligomerisation domain

2011 ◽  
Vol 48 (14) ◽  
pp. 1675-1676
Author(s):  
S.M. Lea ◽  
J.J.E. Caesar ◽  
S. Johnson ◽  
F. Hill
Keyword(s):  
Binding Protein ◽  
Structural Insights

scholarly journals Arranged Sevenfold: Structural Insights into the C-Terminal Oligomerization Domain of Human C4b-Binding Protein

2013 ◽  
Vol 425 (8) ◽  
pp. 1302-1317 ◽  
Author(s):  
Thomas Hofmeyer ◽  
Stefan Schmelz ◽  
Matteo T. Degiacomi ◽  
Matteo Dal Peraro ◽  
Matin Daneschdar ◽  
...  
Keyword(s):  
Binding Protein ◽  
Structural Insights ◽  
Oligomerization Domain
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