scholarly journals Role of Saccharomyces Single-Stranded DNA-Binding Protein RPA in the Strand Invasion Step of Double-Strand Break Repair

PLoS Biology ◽  
2004 ◽  
Vol 2 (1) ◽  
pp. e21 ◽  
Author(s):  
Xuan Wang ◽  
James E Haber
Keyword(s):  
Dna Binding ◽  
Binding Protein ◽  
Dna Binding Protein ◽  
Strand Break ◽  
Double Strand Break ◽  
Double Strand Break Repair ◽  
Single Stranded Dna ◽  
Strand Invasion ◽  
Break Repair

scholarly journals Role of the double-strand break repair pathway in the maintenance of genomic stability

2014 ◽  
Vol 2 (1) ◽  
pp. e968020 ◽  
Author(s):  
Tangui Le Guen ◽  
Sandrine Ragu ◽  
Josée Guirouilh-Barbat ◽  
Bernard S Lopez
Keyword(s):  
Genomic Stability ◽  
Strand Break ◽  
Double Strand Break ◽  
Double Strand Break Repair ◽  
Repair Pathway ◽  
Break Repair

scholarly journals Role of 53BP1 in the Regulation of DNA Double-Strand Break Repair Pathway Choice

2014 ◽  
Vol 181 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Arun Gupta ◽  
Clayton R. Hunt ◽  
Sharmistha Chakraborty ◽  
Raj K. Pandita ◽  
John Yordy ◽  
...  
Keyword(s):  
Strand Break ◽  
Double Strand Break ◽  
Double Strand Break Repair ◽  
Repair Pathway ◽  
Dna Double Strand Break ◽  
Pathway Choice ◽  
Break Repair

Reconstitution of the strand invasion step of double-strand break repair using human Rad51 Rad52 and RPA proteins

2000 ◽  
Vol 304 (2) ◽  
pp. 151-164 ◽  
Author(s):  
Michael J McIlwraith ◽  
Eric Van Dyck ◽  
Jean-Yves Masson ◽  
Alicja Z Stasiak ◽  
Andrzej Stasiak ◽  
...  
Keyword(s):  
Strand Break ◽  
Double Strand Break ◽  
Double Strand Break Repair ◽  
Strand Invasion ◽  
Break Repair ◽  
Human Rad51

scholarly journals Tetrameric Ctp1 coordinates DNA binding and DNA bridging in DNA double-strand-break repair

2015 ◽  
Vol 22 (2) ◽  
pp. 158-166 ◽  
Author(s):  
Sara N Andres ◽  
C Denise Appel ◽  
James W Westmoreland ◽  
Jessica S Williams ◽  
Yvonne Nguyen ◽  
...  
Keyword(s):  
Dna Binding ◽  
Strand Break ◽  
Double Strand Break ◽  
Double Strand Break Repair ◽  
Dna Double Strand Break ◽  
Break Repair

scholarly journals FANCJ (BACH1) helicase forms DNA damage inducible foci with replication protein A and interacts physically and functionally with the single-stranded DNA-binding protein

Blood ◽  
2007 ◽  
Vol 110 (7) ◽  
pp. 2390-2398 ◽  
Author(s):  
Rigu Gupta ◽  
Sudha Sharma ◽  
Joshua A. Sommers ◽  
Mark K. Kenny ◽  
Sharon B. Cantor ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Binding ◽  
Binding Protein ◽  
Critical Role ◽  
Protein A ◽  
Replication Protein A ◽  
Dna Binding Protein ◽  
Replication Protein ◽  
Single Stranded Dna

The BRCA1 associated C-terminal helicase (BACH1, designated FANCJ) is implicated in the chromosomal instability genetic disorder Fanconi anemia (FA) and hereditary breast cancer. A critical role of FANCJ helicase may be to restart replication as a component of downstream events that occur during the repair of DNA cross-links or double-strand breaks. We investigated the potential interaction of FANCJ with replication protein A (RPA), a single-stranded DNA-binding protein implicated in both DNA replication and repair. FANCJ and RPA were shown to coimmunoprecipitate most likely through a direct interaction of FANCJ and the RPA70 subunit. Moreover, dependent on the presence of BRCA1, FANCJ colocalizes with RPA in nuclear foci after DNA damage. Our data are consistent with a model in which FANCJ associates with RPA in a DNA damage-inducible manner and through the protein interaction RPA stimulates FANCJ helicase to better unwind duplex DNA substrates. These findings identify RPA as the first regulatory partner of FANCJ. The FANCJ-RPA interaction is likely to be important for the role of the helicase to more efficiently unwind DNA repair intermediates to maintain genomic stability.

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