Temporal dependence of the diffraction efficiency in KNbO3 at low and high modulation depths

2003 ◽  
Author(s):  
J. Rurik Farías ◽  
J. G. Murillo
Keyword(s):  
Diffraction Efficiency ◽  
Temporal Dependence ◽  
High Modulation

Comparative docking of SARS-CoV-2 receptors antagonists from repurposing drugs

2020 ◽  
Author(s):  
Micael Davi Lima de Oliveira ◽  
Kelson Mota Teixeira de Oliveira
Keyword(s):  
World Health Organisation ◽  
World Health ◽  
Lung Cells ◽  
The Novel ◽  
High Modulation ◽  
Main Protease ◽  
The World ◽  
Novel Coronavirus ◽  
Viral Receptors ◽  
Theoretical Results

According to the World Health Organisation, until 16 June, 2020, the number of confirmed and notified cases of COVID-19 has already exceeded 7.9 million with approximately 434 thousand deaths worldwide. This research aimed to find repurposing antagonists, that may inhibit the activity of the main protease (Mpro) of the SARS-CoV-2 virus, as well as partially modulate the ACE2 receptors largely found in lung cells, and reduce viral replication by inhibiting Nsp12 RNA polymerase. Docking molecular simulations were performed among a total of 60 structures, most of all, published in the literature against the novel coronavirus. The theoretical results indicated that, in comparative terms, paritaprevir, ivermectin, ledipasvir, and simeprevir, are among the most theoretical promising drugs in remission of symptoms from the disease. Furthermore, also corroborate indinavir to the high modulation in viral receptors. The second group of promising drugs includes remdesivir and azithromycin. The repurposing drugs HCQ and chloroquine were not effective in comparative terms to other drugs, as monotherapies, against SARS-CoV-2 infection.

scholarly journals Neuro-Inspired Computing with Spin-VCSELs

2021 ◽  
Vol 11 (9) ◽  
pp. 4232
Author(s):  
Krishan Harkhoe ◽  
Guy Verschaffelt ◽  
Guy Van der Sande
Keyword(s):  
Processing Speed ◽  
Delay Time ◽  
High Speed ◽  
State Of The Art ◽  
Polarization Modulation ◽  
Time Interval ◽  
Computing Technique ◽  
High Modulation ◽  
Short Time ◽  
Modulation Speed

Delay-based reservoir computing (RC), a neuromorphic computing technique, has gathered lots of interest, as it promises compact and high-speed RC implementations. To further boost the computing speeds, we introduce and study an RC setup based on spin-VCSELs, thereby exploiting the high polarization modulation speed inherent to these lasers. Based on numerical simulations, we benchmarked this setup against state-of-the-art delay-based RC systems and its parameter space was analyzed for optimal performance. The high modulation speed enabled us to have more virtual nodes in a shorter time interval. However, we found that at these short time scales, the delay time and feedback rate heavily influence the nonlinear dynamics. Therefore, and contrary to other laser-based RC systems, the delay time has to be optimized in order to obtain good RC performances. We achieved state-of-the-art performances on a benchmark timeseries prediction task. This spin-VCSEL-based RC system shows a ten-fold improvement in processing speed, which can further be enhanced in a straightforward way by increasing the birefringence of the VCSEL chip.

scholarly journals Electromechanically reconfigurable optical nano-kirigami

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Shanshan Chen ◽  
Zhiguang Liu ◽  
Huifeng Du ◽  
Chengchun Tang ◽  
Chang-Yin Ji ◽  
...  
Keyword(s):  
Near Infrared ◽  
Large Range ◽  
Three Dimensional ◽  
High Contrast ◽  
Si Substrate ◽  
High Modulation ◽  
Gold Nanostructure ◽  
Infrared Wavelengths ◽  
On Chip ◽  
Nano Electromechanical System

AbstractKirigami, with facile and automated fashion of three-dimensional (3D) transformations, offers an unconventional approach for realizing cutting-edge optical nano-electromechanical systems. Here, we demonstrate an on-chip and electromechanically reconfigurable nano-kirigami with optical functionalities. The nano-electromechanical system is built on an Au/SiO2/Si substrate and operated via attractive electrostatic forces between the top gold nanostructure and bottom silicon substrate. Large-range nano-kirigami like 3D deformations are clearly observed and reversibly engineered, with scalable pitch size down to 0.975 μm. Broadband nonresonant and narrowband resonant optical reconfigurations are achieved at visible and near-infrared wavelengths, respectively, with a high modulation contrast up to 494%. On-chip modulation of optical helicity is further demonstrated in submicron nano-kirigami at near-infrared wavelengths. Such small-size and high-contrast reconfigurable optical nano-kirigami provides advanced methodologies and platforms for versatile on-chip manipulation of light at nanoscale.

scholarly journals Modeling Best Practice Life Expectancy Using Gumbel Autoregressive Models

Risks ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 51
Author(s):  
Anthony Medford
Keyword(s):  
Time Series ◽  
Life Expectancy ◽  
Extreme Value Theory ◽  
Autoregressive Model ◽  
Best Practice ◽  
Gumbel Distribution ◽  
Value Theory ◽  
Model Diagnostics ◽  
Temporal Dependence ◽  
Simulation Results

Best practice life expectancy has recently been modeled using extreme value theory. In this paper we present the Gumbel autoregressive model of order one—Gumbel AR(1)—as an option for modeling best practice life expectancy. This class of model represents a neat and coherent framework for modeling time series extremes. The Gumbel distribution accounts for the extreme nature of best practice life expectancy, while the AR structure accounts for the temporal dependence in the time series. Model diagnostics and simulation results indicate that these models present a viable alternative to Gaussian AR(1) models when dealing with time series of extremes and merit further exploration.

Sources of the Scalp-Recorded Amplitude-Modulation Following Response

2002 ◽  
Vol 13 (04) ◽  
pp. 188-204 ◽  
Author(s):  
Shigeyuki Kuwada ◽  
Julia S. Anderson ◽  
Ranjan Batra ◽  
Douglas C. Fitzpatrick ◽  
Natacha Teissier ◽  
...  
Keyword(s):  
Animal Model ◽  
Amplitude Modulation ◽  
Single Unit ◽  
Modulation Frequency ◽  
Multiple Sources ◽  
High Modulation ◽  
Before And After ◽  
Single Unit Recordings ◽  
Composite Response ◽  
The Brain

The scalp-recorded amplitude-modulation following response (AMFR)” is gaining recognition as an objective audiometric tool, but little is known about the neural sources that underlie this potential. We hypothesized, based on our human studies and single-unit recordings in animals, that the scalp-recorded AMFR reflects the interaction of multiple sources. We tested this hypothesis using an animal model, the unanesthetized rabbit. We compared AMFRs recorded from the surface of the brain at different locations and before and after the administration of agents likely to enhance or suppress neural generators. We also recorded AMFRs locally at several stations along the auditory neuraxis. We conclude that the surface-recorded AMFR is indeed a composite response from multiple brain generators. Although the response at any modulation frequency can reflect the activity of more than one generator, the AMFRs to low and high modulation frequencies appear to reflect a strong contribution from cortical and subcortical sources, respectively.

scholarly journals Diffraction Efficiency Characteristics for MEMS-Based Phase-Only Spatial Light Modulator with Nonlinear Phase Distribution

Photonics ◽  
2021 ◽  
Vol 8 (3) ◽  
pp. 62
Author(s):  
Remington S. Ketchum ◽  
Pierre-Alexandre Blanche
Keyword(s):  
Diffraction Efficiency ◽  
High Speed ◽  
Phase Distribution ◽  
Complex Structure ◽  
Spatial Light Modulators ◽  
Light Modulator ◽  
Micro Electro Mechanical Systems ◽  
Light Modulators ◽  
Nonlinear Phase ◽  
Liquid Crystal On Silicon

Micro-electro mechanical systems (MEMS)-based phase-only spatial light modulators (PLMs) have the potential to overcome the limited speed of liquid crystal on silicon (LCoS) spatial light modulators (SLMs) and operate at speeds faster than 10 kHz. This expands the practicality of PLMs to several applications, including communications, sensing, and high-speed displays. The complex structure and fabrication requirements for large, 2D MEMS arrays with vertical actuation have kept MEMS-based PLMs out of the market in favor of LCoS SLMs. Recently, Texas Instruments has adapted its existing DMD technology for fabricating MEMS-based PLMs. Here, we characterize the diffraction efficiency for one of these PLMs and examine the effect of a nonlinear distribution of addressable phase states across a range of wavelengths and illumination angles.

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