scholarly journals In vivo Depth Resolved Measurement of Blood Flow with Time Domain Diffuse Correlation Spectroscopy

2018 ◽  
Author(s):  
Marco Pagliazzi ◽  
Sanathana Konugolu Venkata Sekar ◽  
Lorenzo Colombo ◽  
Edoardo Martinenghi ◽  
Jordi Minnema ◽  
...  
Keyword(s):  
Blood Flow ◽  
Time Domain ◽  
Correlation Spectroscopy ◽  
Diffuse Correlation Spectroscopy

scholarly journals Time-domain diffuse correlation spectroscopy (TD-DCS) for noninvasive, depth-dependent blood flow quantification in human tissue in vivo

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Saeed Samaei ◽  
Piotr Sawosz ◽  
Michał Kacprzak ◽  
Żanna Pastuszak ◽  
Dawid Borycki ◽  
...  
Keyword(s):  
Blood Flow ◽  
Time Domain ◽  
Human Tissue ◽  
Correlation Spectroscopy ◽  
Flow Quantification ◽  
Flow Index ◽  
Flow Measurements ◽  
Diffuse Correlation Spectroscopy ◽  
Sensing Applications

AbstractMonitoring of human tissue hemodynamics is invaluable in clinics as the proper blood flow regulates cellular-level metabolism. Time-domain diffuse correlation spectroscopy (TD-DCS) enables noninvasive blood flow measurements by analyzing temporal intensity fluctuations of the scattered light. With time-of-flight (TOF) resolution, TD-DCS should decompose the blood flow at different sample depths. For example, in the human head, it allows us to distinguish blood flows in the scalp, skull, or cortex. However, the tissues are typically polydisperse. So photons with a similar TOF can be scattered from structures that move at different speeds. Here, we introduce a novel approach that takes this problem into account and allows us to quantify the TOF-resolved blood flow of human tissue accurately. We apply this approach to monitor the blood flow index in the human forearm in vivo during the cuff occlusion challenge. We detect depth-dependent reactive hyperemia. Finally, we applied a controllable pressure to the human forehead in vivo to demonstrate that our approach can separate superficial from the deep blood flow. Our results can be beneficial for neuroimaging sensing applications that require short interoptode separation.

In vivo time-domain diffuse correlation spectroscopy above the water absorption peak

2020 ◽  
Vol 45 (13) ◽  
pp. 3377
Author(s):  
L. Colombo ◽  
M. Pagliazzi ◽  
S. Konugolu Venkata Sekar ◽  
D. Contini ◽  
T. Durduran ◽  
...  
Keyword(s):  
Water Absorption ◽  
Time Domain ◽  
Correlation Spectroscopy ◽  
Absorption Peak ◽  
Diffuse Correlation Spectroscopy

scholarly journals Optimization of time domain diffuse correlation spectroscopy parameters for measuring brain blood flow

2021 ◽  
Vol 8 (03) ◽  
Author(s):  
Dibbyan Mazumder ◽  
Melissa M. Wu ◽  
Nisan Ozana ◽  
Davide Tamborini ◽  
Maria Angela Franceschini ◽  
...  
Keyword(s):  
Blood Flow ◽  
Time Domain ◽  
Correlation Spectroscopy ◽  
Brain Blood Flow ◽  
Diffuse Correlation Spectroscopy

scholarly journals Time domain diffuse correlation spectroscopy with a high coherence pulsed source: in vivo and phantom results

2017 ◽  
Vol 8 (11) ◽  
pp. 5311 ◽  
Author(s):  
M. Pagliazzi ◽  
S. Konugolu Venkata Sekar ◽  
L. Colombo ◽  
E. Martinenghi ◽  
J. Minnema ◽  
...  
Keyword(s):  
Time Domain ◽  
Correlation Spectroscopy ◽  
Diffuse Correlation Spectroscopy ◽  
High Coherence

In vivo time-domain diffuse correlation spectroscopy at 1 μm

2021 ◽  
Author(s):  
Lorenzo Colombo ◽  
Marco Pagliazzi ◽  
Sanathana Konugolu Venkata Sekar ◽  
Davide Contini ◽  
Turgut Durduran ◽  
...  
Keyword(s):  
Time Domain ◽  
Correlation Spectroscopy ◽  
Diffuse Correlation Spectroscopy
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