Enhancing SERS detection on biocompatable metallic substrate for Diabetes Diagnosing

2021 ◽  
Author(s):  
Zhiquan Cui ◽  
Libin Lu ◽  
Yingchun Guan ◽  
Seeram Ramakrishna ◽  
Minghui Hong
Author(s):  
J. E. O’Neal ◽  
K. K. Sankaran ◽  
S. M. L. Sastry

Rapid solidification of a molten, multicomponent alloy against a metallic substrate promotes greater microstructural homogeneity and greater solid solubility of alloying elements than can be achieved by slower-cooling casting methods. The supersaturated solid solutions produced by rapid solidification can be subsequently annealed to precipitate, by controlled phase decomposition, uniform 10-100 nm precipitates or dispersoids. TEM studies were made of the precipitation of metastable Al3Li(δ’) and equilibrium AL3H phases and the deformation characteristics of a rapidly solidified Al-3Li-0.2Ti alloy.


2021 ◽  
pp. 129741
Author(s):  
Yingying Sun ◽  
Wan Li ◽  
Liqing Zhao ◽  
Fengyong Li ◽  
Yunfei Xie ◽  
...  

2021 ◽  
pp. 000370282110329
Author(s):  
Ling Wang ◽  
Mario O. Vendrell-Dones ◽  
Chiara Deriu ◽  
Sevde Doğruer ◽  
Peter de B. Harrington ◽  
...  

Recently there has been upsurge in reports that illicit seizures of cocaine and heroin have been adulterated with fentanyl. Surface-enhanced Raman spectroscopy (SERS) provides a useful alternative to current screening procedures that permits detection of trace levels of fentanyl in mixtures. Samples are solubilized and allowed to interact with aggregated colloidal nanostars to produce a rapid and sensitive assay. In this study, we present the quantitative determination of fentanyl in heroin and cocaine using SERS, using a point-and-shoot handheld Raman system. Our protocol is optimized to detect pure fentanyl down to 0.20 ± 0.06 ng/mL and can also distinguish pure cocaine and heroin at ng/mL levels. Multiplex analysis of mixtures is enabled by combining SERS detection with principal component analysis and super partial least squares regression discriminate analysis (SPLS-DA), which allow for the determination of fentanyl as low as 0.05% in simulated seized heroin and 0.10% in simulated seized cocaine samples.


2020 ◽  
Vol 9 (1-2) ◽  
pp. 89-100 ◽  
Author(s):  
Xinyu Hu ◽  
Rui Pan ◽  
Mingyong Cai ◽  
Weijian Liu ◽  
Xiao Luo ◽  
...  

AbstractEvaporation concentration of target analytes dissolved in a water droplet based on superhydrophobic surfaces could be able to break the limits for sensitive trace substance detection techniques (e.g. SERS) and it is promising in the fields such as food safety, eco-pollution, and bioscience. In the present study, polytetrafluoroethylene (PTFE) surfaces were processed by femtosecond laser and the corresponding processing parameter combinations were optimised to obtain surfaces with excellent superhydrophobicity. The optimal parameter combination is: laser power: 6.4 W; scanning spacing: 40 μm; scanning number: 1; and scanning path: 90 degree. For trapping and localising droplets, a tiny square area in the middle of the surface remained unprocessed for each sample. The evaporation and concentration processes of droplets on the optimised surfaces were performed and analyzed, respectively. It is shown that the droplets with targeted solute can successfully collect all solute into the designed trapping areas during evaporation process on our laser fabricated superhydrophobic surface, resulting in detection domains with high solute concentration for SERS characterisation. It is shown that the detected peak intensity of rhodamine 6G with a concentration of 10−6m in SERS characterisation can be obviously enhanced by one or two orders of magnitude on the laser fabricated surfaces compared with that of the unprocessed blank samples.


Small ◽  
2021 ◽  
pp. 2100755
Author(s):  
Sara Gullace ◽  
Verónica Montes‐García ◽  
Victor Martín ◽  
David Larios ◽  
Valentina Girelli Consolaro ◽  
...  

RSC Advances ◽  
2021 ◽  
Vol 11 (16) ◽  
pp. 9518-9527
Author(s):  
Iván A. Ramos ◽  
L. M. León Hilario ◽  
María L. Pedano ◽  
Andres A. Reynoso

Designs with gold covering far from the gap area applied on nanorod-dimer antennas can enable hybrid electrical and SERS detection. Simulations show promising and robust increasement of the enhancement factor with respect to the uncovered dimer.


2021 ◽  
Vol 544 ◽  
pp. 148908
Author(s):  
Jihua Xu ◽  
Yuan Si ◽  
Zhen Li ◽  
Shouzhen Jiang ◽  
Xianwu Xiu ◽  
...  

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