scholarly journals In vivo three-dimensional spectral domain endoscopic optical coherence tomography using a microelectromechanical system mirror

2007 ◽  
Vol 32 (22) ◽  
pp. 3239 ◽  
Author(s):  
Woonggyu Jung ◽  
Daniel T. McCormick ◽  
Yeh-Chan Ahn ◽  
Ali Sepehr ◽  
Matt Brenner ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Three Dimensional ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Microelectromechanical System ◽  
Endoscopic Optical Coherence Tomography

In Vivo Three-Dimensional High-Resolution Imaging of Rodent Retina with Spectral-Domain Optical Coherence Tomography

2007 ◽  
Vol 48 (4) ◽  
pp. 1808 ◽  
Author(s):  
Marco Ruggeri ◽  
Hassan Wehbe ◽  
Shuliang Jiao ◽  
Giovanni Gregori ◽  
Maria E. Jockovich ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
High Resolution ◽  
Three Dimensional ◽  
Spectral Domain ◽  
High Resolution Imaging ◽  
Optical Coherence ◽  
Resolution Imaging

scholarly journals Toward optical coherence tomography on a chip: in vivo three-dimensional human retinal imaging using photonic integrated circuit-based arrayed waveguide gratings

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Elisabet A. Rank ◽  
Ryan Sentosa ◽  
Danielle J. Harper ◽  
Matthias Salas ◽  
Anna Gaugutz ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Integrated Circuit ◽  
Three Dimensional ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Arrayed Waveguide Grating ◽  
Axial Resolution ◽  
Waveguide Grating ◽  
Arrayed Waveguide

AbstractIn this work, we present a significant step toward in vivo ophthalmic optical coherence tomography and angiography on a photonic integrated chip. The diffraction gratings used in spectral-domain optical coherence tomography can be replaced by photonic integrated circuits comprising an arrayed waveguide grating. Two arrayed waveguide grating designs with 256 channels were tested, which enabled the first chip-based optical coherence tomography and angiography in vivo three-dimensional human retinal measurements. Design 1 supports a bandwidth of 22 nm, with which a sensitivity of up to 91 dB (830 µW) and an axial resolution of 10.7 µm was measured. Design 2 supports a bandwidth of 48 nm, with which a sensitivity of 90 dB (480 µW) and an axial resolution of 6.5 µm was measured. The silicon nitride-based integrated optical waveguides were fabricated with a fully CMOS-compatible process, which allows their monolithic co-integration on top of an optoelectronic silicon chip. As a benchmark for chip-based optical coherence tomography, tomograms generated by a commercially available clinical spectral-domain optical coherence tomography system were compared to those acquired with on-chip gratings. The similarities in the tomograms demonstrate the significant clinical potential for further integration of optical coherence tomography on a chip system.

Spectral domain optical coherence tomography for in-vivo three-dimensional retinal imaging of small animals

2007 ◽  
Author(s):  
Marco Ruggeri ◽  
Hassan Wehbe ◽  
Shuliang Jiao ◽  
Giovanni Gregori ◽  
Maria E. Jockovich ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Three Dimensional ◽  
Retinal Imaging ◽  
Spectral Domain ◽  
Small Animals ◽  
Optical Coherence

scholarly journals Design and Implementation Guidelines for a Modular Spectral-Domain Optical Coherence Tomography Scanner

2018 ◽  
Vol 2018 ◽  
pp. 1-22 ◽  
Author(s):  
Farid Atry ◽  
Israel Jacob De La Rosa ◽  
Kevin R. Rarick ◽  
Ramin Pashaie
Keyword(s):  
Optical Coherence Tomography ◽  
Imaging System ◽  
Optical Design ◽  
Spectral Domain ◽  
Design Parameters ◽  
Optical Coherence ◽  
Custom Made ◽  
Essential Knowledge ◽  
Sd Oct

In the past decades, spectral-domain optical coherence tomography (SD-OCT) has transformed into a widely popular imaging technology which is used in many research and clinical applications. Despite such fast growth in the field, the technology has not been readily accessible to many research laboratories either due to the cost or inflexibility of the commercially available systems or due to the lack of essential knowledge in the field of optics to develop custom-made scanners that suit specific applications. This paper aims to provide a detailed discussion on the design and development process of a typical SD-OCT scanner. The effects of multiple design parameters, for the main optical and optomechanical components, on the overall performance of the imaging system are analyzed and discussions are provided to serve as a guideline for the development of a custom SD-OCT system. While this article can be generalized for different applications, we will demonstrate the design of a SD-OCT system and representative results for in vivo brain imaging. We explain procedures to measure the axial and transversal resolutions and field of view of the system and to understand the discrepancies between the experimental and theoretical values. The specific aim of this piece is to facilitate the process of constructing custom-made SD-OCT scanners for research groups with minimum understanding of concepts in optical design and medical imaging.

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