X rays Reflective Multilayers Optic for Microbeam Radiation Therapy at the European Synchrotron Radiation Facility

2007 ◽  
Author(s):  
Christine Borel ◽  
Alberto Bravin ◽  
Christian Morawe ◽  
Herwig Requardt ◽  
Olivier Hignette
Keyword(s):  
Radiation Therapy ◽  
Synchrotron Radiation ◽  
European Synchrotron Radiation Facility ◽  
X Rays ◽  
Microbeam Radiation Therapy

scholarly journals MOSFET dosimetry for microbeam radiation therapy at the European Synchrotron Radiation Facility

2003 ◽  
Vol 30 (4) ◽  
pp. 583-589 ◽  
Author(s):  
E. Bräuer-Krisch ◽  
A. Bravin ◽  
M. Lerch ◽  
A. Rosenfeld ◽  
J. Stepanek ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Synchrotron Radiation ◽  
European Synchrotron Radiation Facility ◽  
Microbeam Radiation Therapy

TLD dosimetry for microbeam radiation therapy at the European Synchrotron Radiation Facility

2008 ◽  
Vol 43 (2-6) ◽  
pp. 990-993 ◽  
Author(s):  
M. Ptaszkiewicz ◽  
E. Braurer-Kirsch ◽  
M. Klosowski ◽  
L. Czopyk ◽  
P. Olko
Keyword(s):  
Radiation Therapy ◽  
Synchrotron Radiation ◽  
European Synchrotron Radiation Facility ◽  
Microbeam Radiation Therapy

Quantitative texture analysis of small domains with synchrotron radiation X-rays

1999 ◽  
Vol 32 (5) ◽  
pp. 841-849 ◽  
Author(s):  
F. Heidelbach ◽  
C. Riekel ◽  
H.-R. Wenk
Keyword(s):  
Synchrotron Radiation ◽  
European Synchrotron Radiation Facility ◽  
Polymer Fibers ◽  
Polycrystalline Materials ◽  
X Rays ◽  
Bone Material ◽  
Experimental Procedure ◽  
Crystallographic Preferred Orientation ◽  
Fine Grained ◽  
Steel Wires

Quantitative analysis of crystallographic preferred orientation (texture) of very small volumes in fine-grained polycrystalline materials has been carried out with a monochromatic X-ray microbeam (≤30 µm) at the microfocus beamline of the European Synchrotron Radiation Facility (ESRF). The experimental procedure is described and illustrated with textures of rolled aluminium, aluminium and steel wires, polymer fibers and natural bone material (apatite).

scholarly journals Medical physics aspects of the synchrotron radiation therapies: Microbeam radiation therapy (MRT) and synchrotron stereotactic radiotherapy (SSRT)

2015 ◽  
Vol 31 (6) ◽  
pp. 568-583 ◽  
Author(s):  
Elke Bräuer-Krisch ◽  
Jean-Francois Adam ◽  
Enver Alagoz ◽  
Stefan Bartzsch ◽  
Jeff Crosbie ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Synchrotron Radiation ◽  
Stereotactic Radiotherapy ◽  
Medical Physics ◽  
Microbeam Radiation Therapy

scholarly journals DNA damage and repair kinetics after microbeam radiation therapy emulation in living cells using monoenergetic synchrotron X-ray microbeams

2011 ◽  
Vol 18 (4) ◽  
pp. 630-636 ◽  
Author(s):  
Carl N. Sprung ◽  
Marian Cholewa ◽  
Noriko Usami ◽  
Katsumi Kobayashi ◽  
Jeffrey C. Crosbie
Keyword(s):  
Dna Damage ◽  
Radiation Therapy ◽  
Cellular Response ◽  
Time Frame ◽  
X Rays ◽  
Bystander Effects ◽  
Dna Damage And Repair ◽  
Tumour Control ◽  
Microbeam Radiation Therapy ◽  
Γh2ax Foci

A novel synchrotron-based approach, known as microbeam radiation therapy (MRT), currently shows considerable promise in increased tumour control and reduced normal tissue damage compared with conventional radiotherapy. Different microbeam widths and separations were investigated using a controlled cell culture system and monoenergetic (5.35 keV) synchrotron X-rays in order to gain further insight into the underlying cellular response to MRT. DNA damage and repair was measured using fluorescent antibodies against phosphorylated histone H2AX, which also allowed us to verify the exact location of the microbeam path. Beam dimensions that reproduced promising MRT strategies were used to identify useful methods to study the underpinnings of MRT. These studies include the investigation of different spatial configurations on bystander effects. γH2AX foci number were robustly induced in directly hit cells and considerable DNA double-strand break repair occurred by 12 h post-10 Gy irradiation; however, many cells had some γH2AX foci at the 12 h time point. γH2AX foci at later time points did not directly correspond with the targeted regions suggesting cell movement or bystander effects as a potential mechanism for MRT effectiveness. Partial irradiation of single nuclei was also investigated and in most cases γH2AX foci were not observed outside the field of irradiation within 1 h after irradiation indicating very little chromatin movement in this time frame. These studies contribute to the understanding of the fundamental radiation biology relating to the MRT response, a potential new therapy for cancer patients.

Three-dimensional coherent diffractive imaging on non-periodic specimens at the ESRF beamline ID10

2014 ◽  
Vol 21 (3) ◽  
pp. 594-599 ◽  
Author(s):  
Y. Chushkin ◽  
F. Zontone ◽  
E. Lima ◽  
L. De Caro ◽  
P. Guardia ◽  
...  
Keyword(s):  
Synchrotron Radiation ◽  
Photon Energy ◽  
Three Dimensional ◽  
European Synchrotron Radiation Facility ◽  
X Rays ◽  
Diffractive Imaging ◽  
Three Dimensional Imaging ◽  
Coherent Diffractive Imaging ◽  
Magnetic Nanorods

The progress of tomographic coherent diffractive imaging with hard X-rays at the ID10 beamline of the European Synchrotron Radiation Facility is presented. The performance of the instrument is demonstrated by imaging a cluster of Fe2P magnetic nanorods at 59 nm 3D resolution by phasing a diffraction volume measured at 8 keV photon energy. The result obtained shows progress in three-dimensional imaging of non-crystalline samples in air with hard X-rays.

scholarly journals X-Tream quality assurance in synchrotron X-ray microbeam radiation therapy

2016 ◽  
Vol 23 (5) ◽  
pp. 1180-1190 ◽  
Author(s):  
Pauline Fournier ◽  
Iwan Cornelius ◽  
Mattia Donzelli ◽  
Herwig Requardt ◽  
Christian Nemoz ◽  
...  
Keyword(s):  
Quality Assurance ◽  
Radiation Therapy ◽  
Clinical Results ◽  
European Synchrotron Radiation Facility ◽  
Field Size ◽  
Radiation Physics ◽  
X Ray ◽  
Energy Beam ◽  
Alignment Procedure ◽  
Microbeam Radiation Therapy

Microbeam radiation therapy (MRT) is a novel irradiation technique for brain tumours treatment currently under development at the European Synchrotron Radiation Facility in Grenoble, France. The technique is based on the spatial fractionation of a highly brilliant synchrotron X-ray beam into an array of microbeams using a multi-slit collimator (MSC). After promising pre-clinical results, veterinary trials have recently commenced requiring the need for dedicated quality assurance (QA) procedures. The quality of MRT treatment demands reproducible and precise spatial fractionation of the incoming synchrotron beam. The intensity profile of the microbeams must also be quickly and quantitatively characterized prior to each treatment for comparison with that used for input to the dose-planning calculations. The Centre for Medical Radiation Physics (University of Wollongong, Australia) has developed an X-ray treatment monitoring system (X-Tream) which incorporates a high-spatial-resolution silicon strip detector (SSD) specifically designed for MRT. In-air measurements of the horizontal profile of the intrinsic microbeam X-ray field in order to determine the relative intensity of each microbeam are presented, and the alignment of the MSC is also assessed. The results show that the SSD is able to resolve individual microbeams which therefore provides invaluable QA of the horizontal field size and microbeam number and shape. They also demonstrate that the SSD used in the X-Tream system is very sensitive to any small misalignment of the MSC. In order to allow as rapid QA as possible, a fast alignment procedure of the SSD based on X-ray imaging with a low-intensity low-energy beam has been developed and is presented in this publication.

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