scholarly journals High contrast three-dimensional photoacoustic imaging through scattering media by localized optical fluence enhancement

2013 ◽  
Vol 21 (22) ◽  
pp. 26671 ◽  
Author(s):  
Antonio M. Caravaca-Aguirre ◽  
Donald B. Conkey ◽  
Jacob D. Dove ◽  
Hengyi Ju ◽  
Todd W. Murray ◽  
...  
Keyword(s):  
Photoacoustic Imaging ◽  
Three Dimensional ◽  
High Contrast ◽  
Scattering Media

scholarly journals High-contrast photoacoustic imaging through scattering media using correlation detection of adaptive time window

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Liqi Yu ◽  
Jialin Sun ◽  
Xinjing Lv ◽  
Qi Feng ◽  
Huimei He ◽  
...  
Keyword(s):  
Light Scattering ◽  
Time Window ◽  
Photoacoustic Imaging ◽  
Signal To Noise Ratio ◽  
Photoacoustic Signal ◽  
High Contrast ◽  
Scattering Media ◽  
Window Method ◽  
Adaptive Time ◽  
Imaging Depth

AbstractPhotoacoustic imaging has the advantages of high contrast and deep imaging depth. However, with the increasing of imaging depth, the signal-to-noise ratio (SNR) of the detected signal decreases, due to the light scattering that seriously affects the recovery image quality. In this paper, we experimentally demonstrated that higher contrast photoacoustic imaging was achieved using photoacoustic wavefront shaping technology in the presence of light scattering and low SNR signals. The imaging contrast is improved from 1.51 to 5.30. More importantly, we propose a dynamic time window method for the photoacoustic signal extraction algorithm, named correlation detection of adaptive time window, which further improves the contrast of photoacoustic imaging to 9.57. Our method effectively improves the contrast of photoacoustic imaging through scattering media.

Three-dimensional photoacoustic imaging through scattering media

2014 ◽  
Author(s):  
Antonio M. Caravaca-Aguirre ◽  
Donald B. Conkey ◽  
Jacob D. Dove ◽  
Hengyi Ju ◽  
Todd W. Murray ◽  
...  
Keyword(s):  
Photoacoustic Imaging ◽  
Three Dimensional ◽  
Scattering Media

Confocal laser microscopy of impregnated central nervous system tissue

1988 ◽  
Vol 46 ◽  
pp. 94-95
Author(s):  
J.N. Turner ◽  
M. Siemens ◽  
D. Szarowski ◽  
D.N. Collins
Keyword(s):  
Electron Microscopy ◽  
Central Nervous System ◽  
Nervous System ◽  
Three Dimensional ◽  
Dimensional Structure ◽  
Confocal Laser ◽  
High Contrast ◽  
Central Nervous System Tissue ◽  
Tissue Samples ◽  
Reflected Light

A classic preparation of central nervous system tissue (CNS) is the Golgi procedure popularized by Cajal. The method is partially specific as only a few cells are impregnated with silver chromate usualy after osmium post fixation. Samples are observable by light (LM) or electron microscopy (EM). However, the impregnation is often so dense that structures are masked in EM, and the osmium background may be undesirable in LM. Gold toning is used for a subtle but high contrast EM preparation, and osmium can be omitted for LM. We are investigating these preparations as part of a study to develop correlative LM and EM (particularly HVEM) methodologies in neurobiology. Confocal light microscopy is particularly useful as the impregnated cells have extensive three-dimensional structure in tissue samples from one to several hundred micrometers thick. Boyde has observed similar preparations in the tandem scanning reflected light microscope (TSRLM).

scholarly journals Electromechanically reconfigurable optical nano-kirigami

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Shanshan Chen ◽  
Zhiguang Liu ◽  
Huifeng Du ◽  
Chengchun Tang ◽  
Chang-Yin Ji ◽  
...  
Keyword(s):  
Near Infrared ◽  
Large Range ◽  
Three Dimensional ◽  
High Contrast ◽  
Si Substrate ◽  
High Modulation ◽  
Gold Nanostructure ◽  
Infrared Wavelengths ◽  
On Chip ◽  
Nano Electromechanical System

AbstractKirigami, with facile and automated fashion of three-dimensional (3D) transformations, offers an unconventional approach for realizing cutting-edge optical nano-electromechanical systems. Here, we demonstrate an on-chip and electromechanically reconfigurable nano-kirigami with optical functionalities. The nano-electromechanical system is built on an Au/SiO2/Si substrate and operated via attractive electrostatic forces between the top gold nanostructure and bottom silicon substrate. Large-range nano-kirigami like 3D deformations are clearly observed and reversibly engineered, with scalable pitch size down to 0.975 μm. Broadband nonresonant and narrowband resonant optical reconfigurations are achieved at visible and near-infrared wavelengths, respectively, with a high modulation contrast up to 494%. On-chip modulation of optical helicity is further demonstrated in submicron nano-kirigami at near-infrared wavelengths. Such small-size and high-contrast reconfigurable optical nano-kirigami provides advanced methodologies and platforms for versatile on-chip manipulation of light at nanoscale.

High-contrast light focusing through scattering media with multi-pixel encoding

2021 ◽  
Vol 14 (9) ◽  
pp. 092009
Author(s):  
Linxian Liu ◽  
Kui Ma ◽  
Yuan Qu ◽  
Qiaozhi He ◽  
Rongjun Shao ◽  
...  
Keyword(s):  
High Contrast ◽  
Scattering Media ◽  
Light Focusing

scholarly journals Preclinical Ultrasound-Guided Photoacoustic Imaging of the Placenta in Normal and Pathologic Pregnancy

2018 ◽  
Vol 17 ◽  
pp. 153601211880272 ◽  
Author(s):  
Liliya M. Yamaleyeva ◽  
K. Bridget Brosnihan ◽  
Lane M. Smith ◽  
Yao Sun
Keyword(s):  
Oxygen Saturation ◽  
Early Identification ◽  
Photoacoustic Imaging ◽  
Three Dimensional ◽  
Normal Pregnancy ◽  
Preclinical Study ◽  
Ultrasound Guided ◽  
3 Dimensional ◽  
Sensitive Tool ◽  
Different Levels

Placental oxygenation varies throughout pregnancy. The detection of early changes in placental oxygenation as pregnancy progresses is important for early identification of preeclampsia or other complications. This invited commentary discusses a recent preclinical study on the application of 3-dimensional photoacoustic imaging (PAI) for assessment of regional variations in placental oxygenation and longitudinal analysis of differences in placental oxygenation throughout normal pregnancy and pregnancy associated with hypertension or placental insufficiency in mice. Three-dimensional PAI more accurately reflects oxygen saturation, hemoglobin concentrations, and changes in oxygen saturation in whole placenta compared to 2-dimensional imaging. These studies suggest that PAI is a sensitive tool to detect different levels of oxygen saturation in the placental and fetal vasculature in pathologic and normal pregnancy in mice.

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