scholarly journals Photoacoustic imaging method based on arc-direction compressed sensing and multi-angle observation

2011 ◽  
Vol 19 (16) ◽  
pp. 14801 ◽  
Author(s):  
Mingjian Sun ◽  
Naizhang Feng ◽  
Yi Shen ◽  
Xiangli Shen ◽  
Liyong Ma ◽  
...  
Keyword(s):  
Compressed Sensing ◽  
Photoacoustic Imaging ◽  
Imaging Method ◽  
Angle Observation

A compressed sensing imaging method based on radar signal construct sparsity basis

2013 ◽  
Author(s):  
Sun Wen-feng ◽  
Fan Xiao-yan ◽  
Song Da-wei ◽  
Li Dong ◽  
Han Tao ◽  
...  
Keyword(s):  
Compressed Sensing ◽  
Radar Signal ◽  
Imaging Method

scholarly journals 4267 Noninvasive hybrid ultrasound and photoacoustic imaging for the assessment of liver fibrosis

2020 ◽  
Vol 4 (s1) ◽  
pp. 110-111
Author(s):  
Laith Riyadh Sultan ◽  
Mrigendra Karmacharya ◽  
Julia D’Souza ◽  
Brooke Kirkham ◽  
Angela K Brice ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Oxygen Saturation ◽  
Photoacoustic Imaging ◽  
Texture Features ◽  
Male Rats ◽  
Imaging Method ◽  
Sampling Errors ◽  
Tissue Heterogeneity ◽  
Time Points ◽  
Over Time

OBJECTIVES/GOALS: The detection of liver fibrotic changes at an early and reversible stage is essential to prevent its progression to end-stage cirrhosis and hepatocellular carcinoma. Liver biopsy, which is the current gold standard for fibrosis assessment, is accompanied by several complications due to its invasive nature in addition to sampling errors and reader variability. In this study, we evaluate the use of quantitative parameters extracted from hybrid ultrasound and photoacoustic imaging to detect and monitor fibrotic changes in a DEN rat model. METHODS/STUDY POPULATION: Liver fibrotic changes were induced in 34 Wistar male rats by oral administration of Diethylnitrosamine (DEN) for 12 weeks. 22 rats were imaged with B-mode ultrasound at 3 different time points (baseline, 10 weeks and 13 weeks) for monitoring liver texture changes. Texture features studied included tissue echointensity (liver brightness normalized to kidney brightness) and tissue heterogeneity. 12 rats were imaged with photoacoustic imaging at 4 time points (baseline, 5 wks, 10 wks, and 13 wks) to look at changes in tissue oxygenation. Hemoglobin oxygen saturation (sO2A) and hemoglobin concentration (HbT) in the right and left lobes of the liver were measured. 8 rats were used as controls. Liver tissue samples were obtained following 13 weeks from DEN start time for METAVIR histopathology staging of fibrosis. RESULTS/ANTICIPATED RESULTS: Texture features studied showed an increase with time in DEN rats. Normalized echointensity increased from 0.28 ± 0.06 at baseline to 0.46 ± 0.10 at 10 weeks (p < 0.0005) and 0.53 ± 0.15 at 13 weeks in DEN rats (p < 0.0005). In the control rats, echointensity remained at an average of 0.25 ± 0.05 (p = 0.31). Tissue heterogeneity increased over time in the DEN-exposed rats from a baseline of 208.7 ± 58.3 to 344.6 ± 52.9 at 10 weeks (p < 0.0005) and 376.8 ± 54.9 at 13 weeks (p = 0.06) however it stayed constant at 225.7 ± 37.6 in control rats (p = 0.58). The quantitative analyses of the photoacoustic signals showed that blood oxygen saturation significantly increased with time. At 5 weeks sO2AvT increased by 53.83 % (± 0.25), and HbT by 35.31 % (± 0.07). Following 10 weeks of DEN; sO2AvT by 92.04 % (± 0.29), and HbT by 55.24 % (± 0.1). All increases were significant p < 0.05. In the 13th week, however, the values of all of these parameters were lower than those in the 10th week, however, the decrease was statistically insignificant. DISCUSSION/SIGNIFICANCE OF IMPACT: Quantitative features from B-mode ultrasound and photoacoustic imaging consistently increased over time corresponding to hepatic damage, inflammation and fibrosis progressed. The use of this hybrid imaging method in clinical practice can help meet the significant need for noninvasive assessment of liver fibrosis.

scholarly journals Multifunctional conjugated polymer nanoparticles for photoacoustic-based multimodal imaging and cancer photothermal therapy

2019 ◽  
Vol 12 (03) ◽  
pp. 1930001 ◽  
Author(s):  
Xiaoju Men ◽  
Zhen Yuan
Keyword(s):  
Conjugated Polymer ◽  
Photothermal Therapy ◽  
Multimodal Imaging ◽  
Photoacoustic Imaging ◽  
Biological Tissues ◽  
Polymer Nanoparticles ◽  
Imaging Method ◽  
Conjugated Polymer Nanoparticles ◽  
Good Biocompatibility ◽  
Cancer Theranostics

Photoacoustic imaging (PAI) is a hybrid imaging method based on photoacoustic (PA) effects, which is able to capture the structure, function, and molecular information of biological tissues with high resolution. To date, therapeutic techniques under the guidance of PAI have provided new strategies for accurate diagnosis and precise treatment of tumors. In particular, conjugated polymer nanoparticles have been extensively inspected for PA-based cancer theranostics largely due to their superior optical properties such as tunable spectrum and large absorption coefficient and their good biocompatibility, and abundant functional groups. This mini-review mainly focuses on the recent advances toward the development of novel conjugated polymer nanoparticles for PA-based multimodal imaging and cancer photothermal therapy.

A Terahertz Compressive Imaging Method Based on Single Detector of Randomly Moving Template

2013 ◽  
Vol 756-759 ◽  
pp. 3785-3788
Author(s):  
Sai Qi Shang ◽  
Min Gang Wang ◽  
Wei Li ◽  
Yao Yang
Keyword(s):  
Compressed Sensing ◽  
Imaging System ◽  
Matching Pursuit ◽  
Terahertz Imaging ◽  
Compressive Sampling ◽  
Imaging Method ◽  
Original Image ◽  
Reconstruction Algorithms ◽  
Compressive Imaging ◽  
Single Detector

Expensiveness and lack of N-pixels sensor affect the application of terahertz imaging. New compressed sensing theory recently achieved a major breakthrough in the field of signal codec, making it possible to recover the original image by using the measured values, which have much smaller number than the pixels in the image. In this paper, by comparing the measurement matrices based on different reconstruction algorithms, such as Orthogonal Matching Pursuit, Compressive Sampling Matching Pursuit and Minimum L_1 Norm algorithms, we proposed a terahertz imaging method based on single detector of randomly moving measurement matrices, designed the mobile random templates and an automatically template changing mechanism, constructed a single detector imaging system, and completed the single terahertz detector imaging experiments.

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