Quantum Lithography Has a Reduced Multiphoton Absorption Rate

2006 ◽  
Author(s):  
Mankei Tsang ◽  
Demetri Psaltis
Keyword(s):  
Absorption Rate ◽  
Multiphoton Absorption

Laser pulse duration effects in Xe2+ ions induced by multiphoton absorption at 0.53 μm

1983 ◽  
Vol 44 (11) ◽  
pp. 1247-1255 ◽  
Author(s):  
A. L'Huillier ◽  
L.A. Lompre ◽  
G. Mainfray ◽  
C. Manus
Keyword(s):  
Laser Pulse ◽  
Pulse Duration ◽  
Laser Pulse Duration ◽  
Multiphoton Absorption

Extravascular Administration of Factor IX: Potential for Replacement Therapy of Canine and Human Hemophilia B

1997 ◽  
Vol 77 (05) ◽  
pp. 0944-0948 ◽  
Author(s):  
Darla Liles ◽  
Charles N Landen ◽  
Dougald M Monroe ◽  
Celeste M Lindley ◽  
Marjorie s Read ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Vitamin K ◽  
Absorption Rate ◽  
Venous Access ◽  
Factor Ix ◽  
Hemophilia B ◽  
Current Therapy ◽  
Home Therapy ◽  
Routes Of Administration ◽  
Plasma Compartment

SummaryCurrent therapy for hemophilia B requires large intravenous doses of factor IX (F.IX) given in the clinic or at home. Although home therapy is possible for many patients, it is often complicated by factors such as the lack of good venous access. Very little is known about extravascular routes for administering proteins like F.IX (57 kD) or other vitamin K-dependent procoagulant factors into the circulation. Questions about the absorption rate from extravascular administration as well as plasma recovery and bioavailability have arisen recently with the growing availibility of highly purified procoagulant proteins and increased interest in gene therapy of hemophilia B. Therefore, a group of studies were undertaken to determine the absorption rate, plasma recovery, and bioavailability of high purity, human plasma-derived F.IX concentrates administered via extravascular routes in hemophilia B dogs and in one human hemophilia B subject. Five hemophilia B dogs were given human F.IX via either a subcutaneous (SC), intramuscular (IM), intra- peritoneal (IP) or intravenous (IV) route. In a subsequent study, a single SC administration of human F.IX was compared to an identical IV dose of F.IX in the human hemophilia B subject. All extravascular routes of F.IX administration in both the canine and human gave lower levels of circulating plasma F.IX than the IV route, however all routes resulted in measurable F.IX activity. Of the extravascular routes, the IM injection in the canine resulted in a bioavailibility of 82.8%, while the SC injection resulted in a bioavailability of 63.5%. F.IX reached the plasma compartment by all extravascular routes used, confirming that F.IX can be absorbed extravascularly. The duration of measurable F.IX activity following extravascular administration is prolonged beyond that typically seen with IV administration. These data show that significant levels of F.IX may be obtained via SC injection in canine and ‘ human hemophilia B subjects and further highlight the potential of extravascular routes of administration for future experimental and clinical uses of F.IX and other procoagulant proteins.

Alcohol Absorption Rate from Different Parts of the Gut

1968 ◽  
Vol 29 (2) ◽  
pp. 308-312
Author(s):  
Ronald G. Elmslie ◽  
Nanette Harvey
Keyword(s):  
Absorption Rate ◽  
Different Parts

Variability of Specific Absorption Rate of Human Body for Various Configurations of Tablet Computer in Vicinity of Abdomen

2015 ◽  
Vol E98.B (7) ◽  
pp. 1173-1181 ◽  
Author(s):  
Akihiro TATENO ◽  
Tomoaki NAGAOKA ◽  
Kazuyuki SAITO ◽  
Soichi WATANABE ◽  
Masaharu TAKAHASHI ◽  
...  
Keyword(s):  
Human Body ◽  
Absorption Rate ◽  
Specific Absorption Rate ◽  
Tablet Computer ◽  
Specific Absorption
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